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A Selective Functionalization Method and Parameter-tunable and Selectively Functionalized Hierarchical Porous Silica Nanomaterials

A technology of porous silica and nanomaterials, applied in the field of hierarchical porous silica nanomaterials, can solve the problem of inability to transport a variety of drugs with mesoporous silica carrier materials.

Active Publication Date: 2019-10-25
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problem in the above-mentioned prior art that mesoporous silica carrier materials cannot be used to transport various drugs, the present invention aims to provide a selective functionalization method and the parameter-adjustable and selective functionalized Hierarchical porous silica nanomaterials

Method used

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  • A Selective Functionalization Method and Parameter-tunable and Selectively Functionalized Hierarchical Porous Silica Nanomaterials
  • A Selective Functionalization Method and Parameter-tunable and Selectively Functionalized Hierarchical Porous Silica Nanomaterials
  • A Selective Functionalization Method and Parameter-tunable and Selectively Functionalized Hierarchical Porous Silica Nanomaterials

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Embodiment 1

[0039] At room temperature,

[0040] a. Set the molar weight to 4.33×10 -6 The block copolymer PS 100 -b-PAA 16 Dissolve in 10mL tetrahydrofuran;

[0041] b. Set the molar mass to 1.36×10 -4 Cetyltrimethylammonium bromide (CTAB, cationic surfactant) was dissolved in 40mL water, after mixing evenly, add 0.5mL ammonia water;

[0042] c. Set the molar mass to 1.44×10 -3 Dissolve ethyl orthosilicate in 80mL ethanol;

[0043] Pour the solution obtained in a into the solution b under stirring conditions, and after standing still for 10-15s, continue to pour the obtained mixed solution into the solution c, and let stand at room temperature for 18h. Hierarchical porous silica nanomaterial precursor (HPSNs-as) was obtained after centrifugal separation, washing and drying; subsequently, HPSNs-as was calcined at 550°C for 6-8 hours to obtain a hierarchical porous silica nanomaterial with a shell thickness of 20nm (HPSNs-CTAB 50 ).

Embodiment 2

[0045] Implementation method and basic formula are identical with embodiment 1, only change CTAB molar weight is 2.74 * 10 -4 , to obtain hierarchically porous silica nanomaterials (HPSNs-CTAB) with a shell thickness of 8 nm 100 ).

Embodiment 3

[0047] Implementation method and basic formula are identical with embodiment 1, only change CTAB molar weight is 5.48 * 10 -4 , to obtain shell-free hierarchical porous silica nanomaterials (HPSNs-CTAB 200 ).

[0048] Figure 2A Be the HPSNs-CTAB of embodiment 1 50 TEM image of the Figure 2B Be the HPSNs-CTAB of embodiment 2 100 TEM image of the Figure 2C Be the HPSNs-CTAB of embodiment 3 200 transmission electron microscope image. Apparently, the obtained hierarchically porous silica nanomaterials exhibit obvious continuous variation in shell thickness. Figure 3A It is the nitrogen adsorption figure of the hierarchical porous silicon oxide nanomaterial prepared in embodiment 1-embodiment 3, Figure 3B It is the pore size distribution figure of the hierarchically porous silicon oxide nanomaterial prepared in embodiment 1-embodiment 3. The results show that the macropore diameter of the hierarchically porous silicon oxide nanomaterial prepared by the method of the p...

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Abstract

The invention relates to a method for carrying out selective functionalization on a hierarchical-pore silicon oxide nano material. The method comprises the following steps: preparing a hierarchical-pore silicon oxide nano material precursor from a block copolymer and a cationic surfactant; carrying out calcination treatment on the hierarchical-pore silicon oxide nano material to obtain a series of structure-and / or-pore-size-parameter-adjustable hierarchical-pore silicon oxide nano materials; carrying out ultrasonic dispersion on the shell-free hierarchical-pore silicon oxide nano material in N-methylpyrrolidone to obtain a block-copolymer-free hierarchical-pore silicon oxide nano material; carrying out amino functionalization to obtain a hierarchical-pore silicon oxide nano material of which the macropore ducts are aminated; and dispersing in an ethanol-ammonium nitrate solution to obtain the selectively-functionalized hierarchical-pore silicon oxide nano material of which the micropore ducts contain rich silicon hydroxyls. The invention also relates to a structure-and / or-pore-size-parameter-adjustable hierarchical-pore silicon oxide nano material. The method provided by the invention has the advantages of simple preparation technique and favorable repetitiveness.

Description

technical field [0001] The invention relates to a hierarchical porous silicon oxide nanometer material, more specifically to a selective functionalization method and the hierarchical porous silicon oxide nanometer material with adjustable parameters and selective functionalization obtained therefrom. Background technique [0002] Compared with traditional molecular drugs, nano "drugs" have some inherent advantages, such as enhanced tumor tissue permeability and retention effect (EPR effect), which provide new methods and ideas for targeted cancer therapy. At present, nanocarrier systems for cancer treatment mainly include organic micelles, dendrimers, metal-organic frameworks (MOFs) and inorganic nanomaterials (Curr.Opin.Colloid In.,2011,16,182-194; Curr. . Opin. Drug Disc., 2007, 10, 756-767; Acc. Chem. Res., 2011, 44, 957-968; Adv. Drug Deliver. Rev., 2010, 62, 362-374). Among numerous nanocarrier systems, mesoporous silica materials have the following advantages: particl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/04
Inventor 牛德超李永生李楠江钰潘珊
Owner EAST CHINA UNIV OF SCI & TECH