Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of salvia miltiorrhiza extract

A technology of Danshen decoction and extract, which is applied in the field of preparation of Danshen decoction extract, can solve the problems of inability to exert the best efficacy of medicinal materials and loss of active ingredients of tanshinones, etc., achieve low production cost, treat myocardial ischemia, and improve The effect of content

Inactive Publication Date: 2017-05-24
泸州医学院附属中医医院
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this method, when extracting the active ingredients of Danshen, the method of decocting is adopted, which leads to a large loss of active ingredients of tanshinone in Danshen, and the best medicinal effect of the medicinal material cannot be exerted.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of salvia miltiorrhiza extract
  • Preparation method of salvia miltiorrhiza extract
  • Preparation method of salvia miltiorrhiza extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 Danshen drink extract of the present invention

[0032] Weigh the raw materials according to the following ratio:

[0033] Salvia 200g, Sandalwood 33.33g and Amomum 33.33g

[0034] The preparation method is as follows:

[0035] a. Add 10 times the amount of water to sandalwood and amomum, soak for 0.5h, distill, collect 416mL of distillate, and set aside;

[0036] b. Salvia miltiorrhiza is percolated with 4 times the amount of 95% ethanol as a solvent, the percolation liquid is collected, the recovered ethanol is concentrated to 800 mL, 120 g of hydroxypropyl-β-cyclodextrin is added, stirred well, and set aside;

[0037] c. Mix the dregs of step a and step b, add 8 times the amount of water, decoct 3 times, 1 hour each time, combine the decoction, filter, concentrate to 584mL, and centrifuge;

[0038] d. Take the centrate from step c, add the percolation liquid of hydroxypropyl-β-cyclodextrin, recover ethanol until there is no alcohol ...

Embodiment 2

[0039] The preparation of embodiment 2 Danshen drink extract of the present invention

[0040] Weigh the raw materials according to the following ratio:

[0041] Salvia 200g, Sandalwood 33.33g and Amomum 33.33g

[0042] The preparation method is as follows:

[0043] a. Add 12 times the amount of water to sandalwood and amomum, soak for 2 hours, distill, collect 416mL of distillate, and set aside;

[0044] b. Salvia miltiorrhiza is percolated with 8 times the amount of 75% ethanol as a solvent, the percolation liquid is collected, the recovered ethanol is concentrated to 800 mL, 120 g of hydroxypropyl-β-cyclodextrin is added, stirred well, and set aside;

[0045] c. Mix the dregs of step a and step b, add 10 times the amount of water, decoct twice for 1 hour each time, combine the decoction, filter, concentrate to 584mL, and centrifuge;

[0046] d. Take the centrate from step c, add the percolation liquid of hydroxypropyl-β-cyclodextrin, recover ethanol until there is no alc...

Embodiment 3

[0047] The preparation of embodiment 3 Danshen drink extract of the present invention

[0048] Weigh the raw materials according to the following ratio:

[0049] Salvia 200g, Sandalwood 33.33g and Amomum 33.33g

[0050] The preparation method is as follows:

[0051] a. Add 8 times the amount of water to sandalwood and amomum, soak for 1 hour, distill, collect 416mL of distillate, and set aside;

[0052] b. Salvia miltiorrhiza is percolated with 2 times the amount of 60% ethanol as a solvent, the percolation liquid is collected, the recovered ethanol is concentrated to 800 mL, 120 g of hydroxypropyl-β-cyclodextrin is added, stirred well, and set aside;

[0053] c. Mix the dregs of step a and step b, add 5 times the amount of water, decoct once, 0.5h each time, combine the decoction, filter, concentrate to 584mL, and centrifuge;

[0054] d. Take the centrate from step c, add the percolation liquid of hydroxypropyl-β-cyclodextrin, recover ethanol until there is no alcohol smel...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
weightaaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of a salvia miltiorrhiza extract. The preparation method comprises the following steps that (a) sandalwood and fructus amomi are taken, water is added for soaking, then distillation and extraction are performed, and distillate and decoction dregs are collected for usage; (b) salvia miltiorrhiza is taken, ethyl alcohol is added for percolation extracting, and leachate and decoction dregs are collected, wherein hydroxypropyl-beta-cyclodextrin is added after leachate concentration, and even stirring is performed for usage; (c) the decoction dregs in the step (a) and decoction dregs in the step (b) are taken and mixed, and water is added to perform extraction, filtration, concentration and centrifugation; (d) the centrifugate in the step c is taken, the leachate of the hydroxypropyl-beta-cyclodextrin in the step (b) is added to recover ethyl alcohol, then the distillate in the step (a) is added, and even stirring and filtration are performed to obtain the extract. The preparation method has the very important significance on the development and application of salvia miltiorrhiza extract preparations.

Description

technical field [0001] The invention relates to a preparation method of an extract of Danshenyin, which belongs to the field of medicines. Background technique [0002] Danshen drink is derived from Chen Xiuyuan's "Shi Fang Ge Kuo", which is composed of salvia miltiorrhiza, sandalwood, and amomum, and has the effects of promoting blood circulation, removing blood stasis, promoting qi and relieving pain. Because of its precise compatibility and remarkable curative effect, it is widely used in the treatment of hypertension, coronary heart disease, angina pectoris, chronic gastritis, gastric and duodenal ulcers, gastric neurosis and other diseases. Danshen decoction has a simple formula, less medicinal taste and few types of chemical components. It only contains volatile oil, phenanthrene quinones, saponins, etc., so it can be used as an ideal formula for research on compound Chinese medicines. At present, there are many methods for preparing the extract of Danshen drink, and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K47/40A61P9/10A61P1/14A61P1/04A61P29/00A61P9/12
Inventor 蒲清荣黄锐杨思进白雪赵剑陈玉兰袁渊李能源罗群李静明俊男
Owner 泸州医学院附属中医医院