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Method for removing endotoxin in biological medical preparations

A technology of biomedicine and endotoxin, applied in the field of biomedicine, can solve problems such as death and fever, and achieve the effect of improving the removal rate

Inactive Publication Date: 2017-05-31
青海七彩花生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If a small amount of endotoxin is mixed into the medicine and injected into the human blood system, it will cause severe fever and even death

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A method for removing endotoxins in biomedical preparations. The method for removing endotoxins in biomedical preparations includes the following steps:

[0021] S1. Pretreatment: Place the raw material liquid of biomedical preparations in a medical metal cup with a mass of 5-8 grams. The medical metal cup must be sterilized in advance, and then put the medical metal cup containing the raw material liquid of biomedical preparations into high pressure Treatment in steam sterilization box, temperature 110-130 degrees Celsius, time 40-50 minutes;

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PUM

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Abstract

The invention discloses a method for removing endotoxin in biological medical preparations. The method for removing the endotoxin in the biological medical preparations comprises the following steps of S1, pretreating; S2, detection of endotoxin; S3, filtering of raw liquid; S4, sample treatment; S5, balance treatment; S6, removing of endotoxin; S7, detection of endotoxin again; S8, storage of raw liquid. The method for removing the endotoxin in the biological medical preparations has the advantages that the external microorganisms and viruses can be primarily removed by pretreatment; by detecting the endotoxin, the content of the endotoxin can be detected; by adjusting the pH (potential of hydrogen) value, the endotoxin can be removed, and the convenience is realized; by heating in the endotoxin removal process, the removal rate of the endotoxin is accelerated.

Description

Technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, the invention also relates to a method for removing endotoxins in biomedical preparations. Background technique [0002] Currently, vaccines, injections, large infusions, radioactive drugs, chemicals, antibiotic drugs, biological products (blood products, vaccines), Chinese herbal medicine injections, dialysate and other biomedical preparations all contain endotoxin; how to effectively remove the pharmaceutical preparations The research on endotoxins and endotoxin removal materials and methods suitable for mass production of pharmaceutical preparations is a hot spot in the field of biomedicine in the future. [0003] Endotoxin is a lipopolysaccharide substance produced in the outer layer of gram-negative bacteria cells, that is, fragments of bacterial corpses. Endotoxins generally exist in the form of aggregates. The chelation of their phosphoric acid groups with divalent metal i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/07A61L2/18
CPCA61L2/07A61L2/18A61L2202/23
Inventor 张文芳
Owner 青海七彩花生物科技有限公司