Pharmaceutical composition for treating chronic gastritis and preparation method of pharmaceutical composition

A chronic gastritis and drug technology, applied in the directions of drug combinations, active ingredients of heterocyclic compounds, active ingredients of anhydrides/acids/halides, etc., can solve the problems of many side reactions, easy recurrence, etc. Ease of use

Inactive Publication Date: 2017-06-13
ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine has quick onset and high clinical remission rate, but it is easy to relapse after drug withdrawal, and there are many side effects of long-term medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A drug combination for treating chronic gastritis, the main raw materials in parts by weight are: 8 parts of rabeprazole sodium, 5 parts of artemisinin, 5 parts of gamma-hydroxybutyric acid, 6 parts of polyvinylpyrrolidone, and 0.04 parts of scopoletin 2 parts of bosentan, 4 parts of allicin, 1 part of biotin, 4 parts of bismuth subnitrate, 10 parts of sodium bicarbonate.

[0016] A preparation method of a drug combination for treating chronic gastritis, the specific steps are:

[0017] First, in a pharmaceutical-grade clean area, weigh rabeprazole sodium, artemisinin, γ-hydroxybutyric acid, polyvinylpyrrolidone, scopoletin, bosentan, allicin, biotin, Bismuth subnitrate and sodium bicarbonate, sieved, mechanically mixed, added ultrapure water, placed in a pharmaceutical mixer, mixed for 4 minutes, controlled RSD ≤ 5%, after mixing, pressed into tablets and dried at low temperature, the temperature was controlled at 4 ° C, packaged The drug combination for treating chro...

Embodiment 2

[0019] A drug combination for treating chronic gastritis, the main raw materials in parts by weight are: 10 parts of rabeprazole sodium, 6 parts of artemisinin, 5 parts of gamma-hydroxybutyric acid, 8 parts of polyvinylpyrrolidone, and 0.07 parts of scopoletin 2 parts of bosentan, 5 parts of allicin, 1 part of biotin, 4 parts of bismuth subnitrate, 12 parts of sodium bicarbonate.

[0020] A preparation method of a drug combination for treating chronic gastritis, the specific steps are:

[0021] First, in a pharmaceutical-grade clean area, weigh rabeprazole sodium, artemisinin, γ-hydroxybutyric acid, polyvinylpyrrolidone, scopoletin, bosentan, allicin, biotin, Bismuth subnitrate and sodium bicarbonate, sieved, mechanically mixed, added ultrapure water, placed in a pharmaceutical mixer, mixed for 4 minutes, controlled RSD ≤ 5%, after mixing, pressed into tablets and dried at low temperature, the temperature was controlled at 4 ° C, packaged The drug combination for treating chr...

Embodiment 3

[0023] A drug combination for treating chronic gastritis, the main raw materials in parts by weight are: 11 parts of rabeprazole sodium, 7 parts of artemisinin, 6 parts of gamma-hydroxybutyric acid, 9 parts of polyvinylpyrrolidone, and 0.09 parts of scopoletin 5 parts of bosentan, 6 parts of allicin, 2 parts of biotin, 5 parts of bismuth subnitrate, 16 parts of sodium bicarbonate.

[0024] A preparation method of a drug combination for treating chronic gastritis, the specific steps are:

[0025] First, in a pharmaceutical-grade clean area, weigh rabeprazole sodium, artemisinin, γ-hydroxybutyric acid, polyvinylpyrrolidone, scopoletin, bosentan, allicin, biotin, Bismuth subnitrate and sodium bicarbonate, sieved, mechanically mixed, added ultrapure water, placed in a pharmaceutical mixer, mixed for 6 minutes, controlled RSD ≤ 5%, after mixing, pressed into tablets and dried at low temperature, controlled at 6 °C, packaged The drug combination for treating chronic gastritis is ob...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating chronic gastritis. The pharmaceutical composition for treating the chronic gastritis is prepared from the following main raw materials in parts by weight: 8 to 14 parts of sodium rabeprazole, 5 to 10 parts of artemisinin, 5 to 7 parts of gamma-hydroxybutyric acid, 6 to 10 parts of polyvinylpyrrolidone, 0.04 to 0.15 part of scopoletin, 2 to 7 parts of bosentan, 4 to 8 parts of garlicin, 1 to 3 parts of biotin, 4 to 6 parts of bismuth subnitrate and 10 to 20 parts of sodium hydrogen carbonate. A Western medicine compound preparation provided by the invention has a reasonable prescription and a clinical test result shows that the curative effect is remarkable; the pharmaceutical composition can be used for effectively treating chronic gastritis symptoms; the pharmaceutical composition has the advantages of small dosage, convenience for orally taking, rapid effect, accurate curative effect, safety and reliability, no side effect and low cost.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a medicine combination for treating chronic gastritis. Background technique [0002] Chronic gastritis is a chronic inflammation or atrophic lesion of the gastric mucosa caused by different etiologies. Clinically, it is mainly divided into three categories: non-atrophic gastritis (superficial gastritis), chronic atrophic gastritis and special type of gastritis. It is a common clinical disease. Frequently-occurring disease, its incidence rate ranks first among all stomach diseases, accounting for more than 80% to 90% of patients receiving gastroscopy, and its incidence rate increases with age. Chronic non-atrophic gastritis can develop into chronic atrophic gastritis, to gastric cancer, which seriously threatens the life of the patient. Western medicine generally believes that the cause of chronic gastritis is chronic inflammation of the gastric mucosa caused by physical, chem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K31/4439A61K31/366A61K31/19A61K31/506A61K31/4188A61K31/37A61K31/255A61P1/04
CPCA61K33/24A61K31/19A61K31/255A61K31/366A61K31/37A61K31/4188A61K31/4439A61K31/506
Inventor 不公告发明人
Owner ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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