Application of quinine compounds to tumor treatment, method for using quinine compounds in tumor treatment, and pharmaceutical composition
A composition and compound technology, applied in the directions of drug combinations, anti-tumor drugs, active ingredients of heterocyclic compounds, etc., can solve the problems of immune system damage, unsatisfactory curative effect, etc., achieve good curative effect, friendly body disturbance, and improve curative effect Effect
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Embodiment 1
[0055] Embodiment 1: the preparation of quinine compound injection
[0056] Table 1
[0057]
[0058] Remarks: + refers to water for injection except for the composition in the table
[0059] -Refers to does not contain.
[0060] In Table 1, the preparation method of A2 is as follows: at room temperature, add 0.2ml of benzyl alcohol to 8.5ml of water for injection to dissolve, then add 758mg of quinine dihydrochloride dry powder to the solution for dissolution, then add water for injection to make the total volume reach 10ml , mix evenly and then pack into 2ml / bottle for later use, so as to prepare injection A2.
[0061] The preparation method of A3 is as follows: at room temperature, add 0.2ml of benzyl alcohol into 8.0ml of water for injection to dissolve, then add 758mg of quinine dihydrochloride dry powder into the solution to dissolve, then add 1000mg of polidocanol to dissolve, and finally add water for injection Make the total volume reach 10ml, after mixing evenl...
Embodiment 2
[0067] Embodiment 2: the optimal condition research of application
[0068]In antitumor experiments, positive controls are usually existing clinical drugs (such as cisplatin, doxorubicin, mitomycin, gemcitabine, 5-fluoropyrimidine, etc.). Their clinical significance lies in low toxicity and high activity, such as low toxicity and up to 75% tumor inhibition rate in animal experiments. The term "anti-tumor activity", sometimes referred to as activity, refers to the property of having certain anti-tumor similarities compared with existing clinical drugs. A substance has a lower half-inhibitory concentration (abbreviated as IC) in vitro experiments 50 , usually less than 50 μM in the 72-hour inhibition response), or show a higher tumor growth inhibition rate in animal experiments (referred to as tumor inhibition rate, usually greater than 40% but less than 75%), it is considered to be incompatible with existing clinical drugs With the similarity, thus showing the anti-tumor acti...
Embodiment 3
[0099] Embodiment 3: application in the treatment of breast cancer
[0100] The experimental animals were nude mice bearing breast cancer cells, and were divided into a negative control group, a positive control group and a drug study group. The positive control group was injected with conventional antitumor drug doxorubicin (7 mg / kg) into the tail vein, and the negative control group was injected with normal saline. The study of quinines was first carried out using quinine dihydrochloride. The preparation method of the injections of each drug study group (B, C, D, E, F group) is the same as the preparation method of A2 in Table 1, containing 2% benzyl alcohol, but containing quinine dihydrochloride of required different concentrations , and the injection concentrations were 0.025M, 0.05M, 0.15M, 0.25M, and 0.4M, respectively. In the drug study group, the injection dose in the tumor area was less than 300 mg quinine dihydrochloride / kg, the injection volume was determined by ...
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