Formula of pharmaceutical composition for treating pulmonary tuberculosis and preparation method thereof

A preparation method and composition technology, which is applied in the field of medicine, can solve problems such as digestive system adverse reactions and liver damage, and achieve the effects of simple operation, delaying drug resistance, and alleviating discomfort

Inactive Publication Date: 2017-06-20
THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the process of drug treatment of tuberculosis, patients usually suffer from anorexia, nausea, stomach pain and loss of appetite, damage to the liver is more common, and adverse reactions to the digestive system of the human bo

Method used

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  • Formula of pharmaceutical composition for treating pulmonary tuberculosis and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A prescription of the pharmaceutical composition for treating pulmonary tuberculosis, the main components of the prescription of the pharmaceutical composition for treating pulmonary tuberculosis include:

[0030] Isoniazid: 0.3;

[0031] Rifampicin: 0.38g;

[0032] Pyrazinamide: 0.75g;

[0033] Streptomycin: 0.6g, streptomycin is an antibiotic extracted from Streptomyces griseus culture fluid, and the minimum inhibitory concentration of streptomycin is 0.5mg / ml;

[0034] Ethambutol: 1.2g;

[0035] Aminosalicylic acid: 0.455g;

[0036] Tryptophan: 2.5g.

[0037] The present invention also provides a preparation method of the pharmaceutical composition for treating pulmonary tuberculosis, the specific steps of the preparation method of the pharmaceutical composition for the treatment of pulmonary tuberculosis are as follows:

[0038] S1: Take fresh water for injection in a 500ml container and heat it to 90°C. The pH value of the water for injection is 5.8, and the w...

Embodiment 2

[0045] A prescription of the pharmaceutical composition for treating pulmonary tuberculosis, the main components of the prescription of the pharmaceutical composition for treating pulmonary tuberculosis include:

[0046] Isoniazid: 0.5g;

[0047] Rifampicin: 0.58g;

[0048] Pyrazinamide: 0.95g;

[0049] Streptomycin: 0.8g, streptomycin is an antibiotic extracted from Streptomyces griseus culture fluid, and the minimum inhibitory concentration of streptomycin is 0.5mg / ml;

[0050] Ethambutol: 1.4g;

[0051] Aminosalicylic acid: 0.65g;

[0052] Tryptophan: 4.5g.

[0053] The present invention also provides a preparation method of the pharmaceutical composition for treating pulmonary tuberculosis, the specific steps of the preparation method of the pharmaceutical composition for the treatment of pulmonary tuberculosis are as follows:

[0054] S1: Take fresh water for injection in a 500ml container and heat it up to 90°C. The pH value of the water for injection is 6.6, and th...

Embodiment 3

[0061] A prescription of the pharmaceutical composition for treating pulmonary tuberculosis, the main components of the prescription of the pharmaceutical composition for treating pulmonary tuberculosis include:

[0062] Isoniazid: 0.4g;

[0063] Rifampicin: 0.48g;

[0064] Pyrazinamide: 0.85g;

[0065] Streptomycin: 0.7g, streptomycin is an antibiotic extracted from Streptomyces griseus culture fluid, and the minimum inhibitory concentration of streptomycin is 0.5mg / ml;

[0066] Ethambutol: 1.3g;

[0067] Aminosalicylic acid: 0.55g;

[0068] Tryptophan: 3.5g.

[0069] The present invention also provides a preparation method of the pharmaceutical composition for treating pulmonary tuberculosis, the specific steps of the preparation method of the pharmaceutical composition for the treatment of pulmonary tuberculosis are as follows:

[0070] S1: Take fresh water for injection in a 500ml container and heat it to 90°C. The pH value of the water for injection is 6, and the wat...

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Abstract

The invention discloses a formula of a pharmaceutical composition for treating pulmonary tuberculosis in the technical field of medicine. The formula contains the following major components: 0.3-0.5 g of isoniazid; 0.38-0.58 g of rifampin; 0.75-0.95 g of pyrazine amide; 0.6-0.8 g of streptomycin; 1.2-1.4 g of ethambutol; 0.45-0.65 g of aminosalicylic acid; and 2.5-4.5 g of tryptophan. The invention also provides a preparation method of a pharmaceutical composition for treating pulmonary tuberculosis, which specifically comprises the following steps: S1, adding water for injection to a container; S2, sequentially adding combination drugs; S3, adding tryptophan and uniformly stirring; S4, adding a stabilizer and adjusting the pH value of the solution; S5, adding activated carbon; and S6, performing high-temperature sterilization of subpackaging. According to the invention, the tryptophan is added, which can alleviate the discomfort of a tuberculosis patient caused by side effects of the medicine; the cooperative use of aminosalicylic acid, isoniazid and rifampin can delay the generation of drug tolerance of a tuberculosis patient. The preparation method is simple in operation and suitable for large-batch production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a formula of a medicinal composition for treating pulmonary tuberculosis and a preparation method thereof. Background technique [0002] Tuberculosis is an infectious disease of the lungs caused by Mycobacterium tuberculosis. It is a disease that seriously threatens human health. The source of infection of Mycobacterium tuberculosis (abbreviated as Mycobacterium tuberculosis, the same below) is mainly pulmonary tuberculosis patients who excrete bacteria and spread through the respiratory tract. Healthy people infected with tuberculosis do not necessarily have the disease, only when the body's immunity is weakened. Statistics from the World Health Organization (WHO) show that 8 to 10 million cases of tuberculosis occur in the world every year, and about 3 million people die from tuberculosis every year. It is the single infectious disease that causes the largest number of death...

Claims

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Application Information

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IPC IPC(8): A61K31/7036A61K31/4409A61K31/496A61K31/4965A61K31/133A61K31/606A61K31/405A61K47/18A61P31/06
CPCA61K31/7036A61K31/133A61K31/405A61K31/4409A61K31/496A61K31/4965A61K31/606A61K47/183A61K2300/00
Inventor 高渐联崔俊伟刘小红张边防陈颖卢乙众
Owner THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIV
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