harringtonine alkaloids, their preparation method and use

A technology of harringtonine and alkaloids, which is applied in the field of pharmaceutical compounds and their preparation, harringtonine alkaloids, and can solve problems such as long synthetic lines and difficult industrial production
CN106866690BActive Publication Date: 2019-10-11NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANKAI UNIV
Publication Date
2019-10-11

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Abstract

The present invention relates to the field of pharmaceutical compounds and preparation methods thereof, and particularly relates to a Cephalotaxus ester alkaloid, and preparation method and use thereof. The Cephalotaxus ester alkaloid has a structure of formula (I). The present invention further provides a preparation method of the compound, comprising reacting a compound of formula (11) with a compound of formula (12) in the presence of a Lewis acid.
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Description

technical field

[0001] The invention relates to harringtonine alkaloids, a preparation method and application thereof, and belongs to the field of pharmaceutical compounds and preparation methods thereof. Background technique

[0002] Harringtonine alkaloids such as harringtonine 1 (Harringtonine, HT), homoharringtonine 2 (Homoharringtonine, HHT), deoxyharringtonine 3 (Deoxyharringtonine, DHT) and isoharringtonine Base 4 (Isoharringtonine, IHT) is a broad-spectrum anticancer drug. Wherein homoharringtonine 2 was loaded into Chinese Pharmacopoeia in 1990, for the clinical treatment of acute non-lymphatic leukemia, and has been clinically used so far (Chinese Pharmacopoeia 1990 edition two, 1990, 588; Chinese Pharmacopoeia 2005 edition two, 2005 , 629).

[0003]

[0004] Formula (6) is the general formula of natural harringtonine alkaloids, and its molecular structure is composed of harringtonine core and side chain. The mother core harringtonine (5) has no physiological ...

Claims

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