Application of heat-sensitive materials in the preparation of injections for protecting the surrounding structures of organs during thermal ablation

A heat-sensitive material and thermal ablation technology, applied in the field of medicine, can solve the problems of easy tearing of perihepatic structures, human injury, bleeding or tearing of the intestinal wall.

Active Publication Date: 2020-05-22
BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the case of intra-abdominal adhesions, the mechanical separation through balloon inflation is easy to tear the perihepatic structure, causing bleeding or intestinal wall tearing, etc.
In addition, this technique has high requirements for the operator, and the balloon needs to be placed in an accurate position without deviation.
Finally, this technology is generally carried out under the guidance of CT, which has radioactive radiation and has certain damage to the human body.

Method used

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  • Application of heat-sensitive materials in the preparation of injections for protecting the surrounding structures of organs during thermal ablation
  • Application of heat-sensitive materials in the preparation of injections for protecting the surrounding structures of organs during thermal ablation
  • Application of heat-sensitive materials in the preparation of injections for protecting the surrounding structures of organs during thermal ablation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] The heat-sensitive injection uses Matrigel basement membrane matrix (BD Company, USA), which was previously used in cell culture experiments. Its main components are composed of laminin, type IV collagen, nestin, heparan sulfate glycoprotein, etc., and also contain a temperature-sensitive hydrogel. Matrigel gels quickly at a temperature of 22-35°C, so it should be frozen and thawed overnight on ice at 0-4°C when dissolving (it will partially gel as the temperature rises above 4°C). All supplies should be placed in an ice bath prior to use, and Matrigel must be administered with a pre-cooled syringe or catheter. BD Matrigel basement membrane matrix can form a semi-solid gel within 1min at 37°C, and polymerize to form a three-dimensional matrix with biological activity, which simulates the structure, composition, physical properties and functions of cell basement membranes in vivo, which is beneficial to the growth of cells in vitro Culture and differentiation, and studi...

Embodiment 2

[0078] The heat-sensitive injection uses a temperature-sensitive poloxamer aqueous solution, of which 15.4% is poloxamer P407. This polymer hydrogel is a mixed system of a three-dimensional space cross-linked network composed of polymers and water. The traditional Used in non-ionic surfactants, in recent years, it has been widely used in the fields of drug control release. This hydrogel is in a low-viscosity liquid state at 14-20°C (room temperature), and turns into a gel at 34-37°C (close to body temperature), with the highest viscosity at 40°C. We put the aqueous solution of poloxamer produced by Sigma company at room temperature to maintain a liquid state.

[0079] Using the Sprague Dawley rat experiment, radiofrequency ablation of liver tumors adjacent to the diaphragm, ultrasound-guided injection of an appropriate amount (10ml) of poloxamer aqueous solution in the gap between the liver ablation area and the diaphragm before treatment to form a 5-10mm thick isolation zone ....

Embodiment 3

[0081] The temperature-sensitive injection uses a temperature-sensitive temperature-sensitive nano-polyhydrogel (N-isopropylacrylamide-co-acrylamide) (referred to as temperature-sensitive nanogel) (Institute of Materia Medica, School of Life Science and Technology, Huazhong University of Science and Technology development). This is a smart nanomaterial that can produce structural and performance changes in response to small changes in temperature. It is currently used in the field of vascular embolization. Studies have shown that temperature-sensitive nanogels have low sol viscosity and high gel strength, and have rapid temperature response and significant thixotropy. At a normal temperature of about 20°C, the temperature-sensitive nanogel is in a liquid state with good fluidity. When the temperature rises to 34-37°C, it will completely lose its fluidity within 12 seconds and become a gel state.

[0082] Using the Sprague Dawley SD rat experiment, radiofrequency ablation of l...

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Abstract

The invention provides application of a thermosensitive material in preparation of an injection for protecting an organ peripheral structure in thermal ablation. The thermosensitive material is used for protecting an organ peripheral structure when a mammal abdominal solid organ is adjacently subjected to thermal ablation by a membrane tumor. The injection material is in a liquid state with good fluidity at a temperature of 0-4 DEG C or 10-22 DEG C, and is converted from liquid phase to solid phase or semi-solid phase without fluidity when the temperature is increased to 34-37 DEG C, so as to be able to stay in the injection position; and optimally, the injection material is converted into solid phase or semi-solid phase without fluidity within 10 seconds to 3 minutes. The injection prepared from the thermosensitive material is used for intraperitoneal injection instead of a conventional injection, so that an organ is separated from the peripheral structure which is easily injured by heat, an enough protecting thickness can be achieved, the thermal ablation can be safe, and the defects of large fluidity, short staying in a target region, durable perfusion requirement and the like of a conventional liquid.

Description

technical field [0001] The present invention relates to the field of medicine, in particular, it relates to the application of a heat-sensitive material in the preparation of injections for surrounding structures during thermal ablation of protective organs, and more specifically, it relates to the application of a heat-sensitive material in the preparation of mammalian abdominal cavity solids. During the thermal ablation of tumors adjacent to the viscera, the application of injections to protect the surrounding structures during thermal ablation of the viscera. Background technique [0002] "Tumor thermal ablation" is defined as direct application of thermal energy-based treatment to a tumor (or several tumors) to eliminate or completely destroy the tumor, including radiofrequency ablation, microwave ablation, laser ablation, and high-intensity ultrasound focused therapy. Among them, radiofrequency ablation is the most widely used thermal ablation technique in clinical prac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/14A61L31/16A61L31/18
CPCA61L31/042A61L31/06A61L31/145A61L31/148A61L31/16A61L31/18A61L2400/06
Inventor 杨薇付静静
Owner BEIJING CANCER HOSPITAL PEKING UNIV CANCER HOSPITAL
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