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6 results about "Oncothermia" patented technology
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Oncothermia, i. e. the modulated deep electro-hyperthermia system is a fast-developing supportive, complementary treatment method against different types of tumors. The principles are based on the classical method of hyperthermia, but the aim, beside the absolute increase in temperature, is especially the direct electric-field energy absorption in the extracellular liquid and destroying the membrane of the cancer cells. Oncothermia's effect is synergic to radiotherapy and to numerous chemotherapies. Furthermore, it leads to an increased immunogenicity and effectively reduces the pain of the patient. Hyperthermia has been described as the "oldest identified weapon against cancer." It has been used since at least 1989. Oncothermia in general is not used as sole therapy. It is usually combined with chemotherapy, radiotherapy or other therapies and their combination. The method transfers energy using the principle of capacitive coupling of radio waves of 13,56-MHz. No external shielding is needed. Oncothermia utilizes the special absorption rate of the near-membrane extracellular liquid of the tumor.
Wireless intelligently controlled system for intravesical tumor hyperthermia
includes an implantable intravesical floating hyperthermia device and an external pulse heating apparatus. The floating device includes a sealed non-metallic housing, a metal coil configured to inductively couple with an alternating magnetic field generated outside the human body to generate heat for tumor hyperthermia, a temperature sensor, a wireless transmission module, and a power supply module. The pulse heating apparatus includes at least one magnetic field generation module and a control module that controls the heating temperature according to the temperature signal from the floating device. The system supports multiple, timed, and temperature-controlled hyperthermia sessions with a single transurethral insertion, reducing patient trauma and enabling outpatient self-management.
Owner:THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV +1
Method and device for acquiring temperature field of tumor thermal ablation operation
The application relates to the technical field of tumor hyperthermia, in particular to a temperature field acquisition method and device for tumor thermal ablation surgery, wherein the method comprises the following steps: segmenting a three-dimensional tumor model from a three-dimensional magnetic resonance image in a target liver; calculating the centroid position of the three-dimensional tumor according to the three-dimensional tumor, and solving the ellipsoid parameters of the three-dimensional tumor; querying a preset database by using the ellipsoid parameters to obtain the closest ellipsoid data, and acquiring the current temperature field distribution from the closest ellipsoid data. Therefore, the problems in the prior art that the finite element calculation is huge in amount, time-consuming, and the temperature field cannot be acquired and monitored in real time, the accuracy and real-time performance of the surgery are reduced, and the requirements of the tumor thermal ablation surgery cannot be met are solved.
Owner:TSINGHUA UNIVERSITY
Deep frequency conversion phased array tumor focusing hyperthermia method and system
This invention belongs to the field of hyperthermia equipment control technology, and particularly relates to a deep-conversion phased array focused tumor hyperthermia method and system. During the radio frequency emission pause, backscattered signals containing tissue dielectric mutation characteristics are acquired. A coherent crosstalk assessment matrix is ​​constructed, and a residual compensation phase sequence is extracted to reshape the coherent superposition of the beam in the target area. The deviation between the planned and actual temperature rise rate in the target area is converted into a global power boost compensation coefficient through nonlinear logarithmic mapping to smoothly compensate for energy drops. The standing wave ratio (VSWR) of each channel is monitored in real time, and a piecewise exponential penalty mechanism is used to calculate the safety tolerance factor. The power reduced from high-risk channels is weighted and allocated to safe channels to maintain a constant total energy flux. This invention improves the focus accuracy in heterogeneous target areas, effectively suppresses thermodynamic oscillations, and safely avoids the risk of hardware power amplifier damage.
Owner:JILIN ZHONGCHI MEDICAL TECH CO LTD
A liver cancer incomplete radiofrequency ablation mouse model and a construction method and application thereof
The application provides a liver cancer incomplete radiofrequency ablation mouse model and a construction method and application thereof. The method comprises the following steps: S1. Injecting a liver cancer cell suspension into a mouse, so that the liver cancer cells form tumors in the mouse; and S2. Implementing local radiofrequency ablation on the mouse with tumors formed in vivo, to obtain a liver cancer incomplete radiofrequency ablation mouse model. The liver cancer incomplete radiofrequency ablation mouse model obtained by the method provided by the application can simulate the biological process after tumor thermal ablation, overcome the difficulty that the tumor microenvironment is difficult to completely simulate in vitro, and can be directly used for researching the adaptation of liver cancer and the influence on the liver cancer microenvironment, thereby providing an important scientific basis for the research on the progress after liver cancer ablation.
Owner:SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
A variable frequency radiator array structure
The application discloses a variable frequency radiator array structure. The device comprises a plurality of low-frequency dipole antenna units with a working frequency lower than 433 MHz, which are arranged along an elliptical or quasi-elliptical track to form a radiator array. By independently regulating the amplitude (or power) and phase of the input signals of each antenna unit, the electromagnetic energy generated by the radiator array can be focused in a predetermined target area of deep tissues of a human body, and the size of the focus spot can be regulated by regulating the working frequency. A water bag filled with deionized water is installed on the inner side of the device, and the energy penetration efficiency of the array radiator is improved through impedance matching, while the body surface temperature is kept constant to prevent high-heat burns. The system can realize non-invasive and tunable deep targeted heating, and is suitable for medical fields such as tumor hyperthermia, and has the advantages of large penetration depth, accurate focusing and high safety.
Owner:JILIN ZHONGCHI MEDICAL TECH CO LTD
A non-destructive temperature measurement method based on sound absorption coefficient
ActiveCN117073865BOncothermiaHyperthermia Treatment
This invention discloses a non-destructive temperature measurement method based on the sound absorption coefficient. It involves using an ultrasonic probe to emit ultrasonic pulses that strike a sample through a medium (pure water) at different temperatures, generating echoes. The relationship between acoustic parameters such as sound velocity and echo energy and temperature is determined by analyzing the time-shift and amplitude changes of the echoes at different temperatures. The sound absorption coefficient is inversely proportional to the cube of the sound velocity and the echo amplitude. The sound absorption coefficient is calculated using a formula, and its correlation curve with temperature is fitted. This curve is then compared with the correlation curve of measured echo energy versus temperature for verification. This method offers higher accuracy and is more suitable for non-invasive temperature measurement in tumor hyperthermia.
Owner:HEFEI UNIV OF TECH