16 results about "Oncothermia" patented technology

The application discloses a brain tumor detection method based on an attention mechanism and MRI multi-modal fusion, relates to the technical field of brain tumor image analysis, and comprises the following steps: acquiring a first tumor heat map and a second tumor heat map; calculating a consistency measurement score of the two heat maps; if the score does not satisfy a preset threshold, starting feedback iteration: merging images to generate an enhanced training set, and performing weighted training on a loss term corresponding to a multi-modal image pair by taking the normalized measurement score as a quality weight, and iteratively optimizing a model until a condition is satisfied; and finally outputting a brain tumor detection result with high confidence. The application introduces an internal closed-loop verification and self-adaptive optimization mechanism, effectively solves the core problem that the confidence of a detection result cannot be verified and guaranteed in the prior art, and finally realizes the accuracy of closed-loop verification and optimization of the confidence of brain tumor detection based on the attention mechanism and the MRI multi-modal fusion.

includes an implantable intravesical floating hyperthermia device and an external pulse heating apparatus. The floating device includes a sealed non-metallic housing, a metal coil configured to inductively couple with an alternating magnetic field generated outside the human body to generate heat for tumor hyperthermia, a temperature sensor, a wireless transmission module, and a power supply module. The pulse heating apparatus includes at least one magnetic field generation module and a control module that controls the heating temperature according to the temperature signal from the floating device. The system supports multiple, timed, and temperature-controlled hyperthermia sessions with a single transurethral insertion, reducing patient trauma and enabling outpatient self-management.

The utility model relates to the technical field of medical care, in particular to a tumor thermal therapy nursing pillow which comprises an inner container, an electric heating wire, a pillow body, a plurality of magnetic therapy buckles and a fixing assembly, and the fixing assembly comprises a first fixing belt, an inserting piece, a second fixing belt, an inserting frame, a rotating piece, a gear and two locking structures. The first fixing belt and the second fixing belt are pulled to be wound around the nursing bed board, the inserting pieces are inserted into the inserting frames, then the rotating pieces are operated to enable the gears to rotate, the gears rotate to drive the two racks through meshing to be matched with guiding of the guiding pieces, the abutting pieces are driven to be inserted into the inserting pieces in the inserting frames, and fixing of the inserting pieces is completed. Therefore, the problem that an existing tumor thermal therapy nursing pillow is of a square structure and is not provided with a fixing structure, so that when the pillow is directly placed on a nursing bed to be used in the using process, the position of the pillow may deviate, and then the thermal therapy effect is affected is solved.

The present invention discloses a magnetic resonance-guided focused microwave brain tumor thermal ablation system and a focusing adjustment method. The present invention integrates the three-dimensional data of MRI and CT, selects the microwave frequency suitable for the size and depth of the tumor, and designs a suitable antenna and a cross-polarized antenna phased array. The differential evolution algorithm is used to optimize the antenna output power and phase to achieve precise focusing of microwave energy, increase the tumor temperature to the ablation level, and maintain the safe temperature of healthy tissue. The system effectively suppresses the adverse effects of brain tissue, including the skull, on microwave penetration, and achieves precise ablation of tumors through a small number of antennas combined with an iterative algorithm. Combined with MRI guidance and real-time temperature monitoring, the accuracy and safety of thermal ablation are ensured, non-invasive radical treatment of brain tumors is achieved, and the problem of drugs being unable to penetrate the blood-brain barrier is overcome. In addition, this technology can also be used to treat other diseases such as liver cancer, pancreatic cancer, thyroid cancer, breast cancer, kidney cancer, bone cancer, bladder cancer, and gallbladder cancer.

The application relates to the technical field of tumor hyperthermia, in particular to a temperature field acquisition method and device for tumor thermal ablation surgery, wherein the method comprises the following steps: segmenting a three-dimensional tumor model from a three-dimensional magnetic resonance image in a target liver; calculating the centroid position of the three-dimensional tumor according to the three-dimensional tumor, and solving the ellipsoid parameters of the three-dimensional tumor; querying a preset database by using the ellipsoid parameters to obtain the closest ellipsoid data, and acquiring the current temperature field distribution from the closest ellipsoid data. Therefore, the problems in the prior art that the finite element calculation is huge in amount, time-consuming, and the temperature field cannot be acquired and monitored in real time, the accuracy and real-time performance of the surgery are reduced, and the requirements of the tumor thermal ablation surgery cannot be met are solved.

The invention discloses a preparation method and application of injectable photo-crosslinked GelMA / MPDA hydrogel, and belongs to the technical field of medical biological material preparation. The method comprises the following steps: preparing methacrylic anhydride gelatin (GelMA) and polydopamine beads (MPDA) with a mesoporous structure; the preparation method comprises the following steps: mixing a GelMA aqueous solution, MPDA and a photoinitiator, and stirring in a dark place to prepare the injectable photo-crosslinked GelMA / MPDA hydrogel. After being cured, the injectable hydrogel has a uniform honeycomb porous structure and has good injectability and biocompatibility, the photothermal conversion performance of the material is remarkably improved, tumor thermal therapy triggered by near-infrared light is achieved, drug loading and light-controlled release are achieved through mesoporous adsorption and chemical action, and the injectable hydrogel has a good application prospect. Therefore, a novel active controllable drug delivery platform is provided for photothermal-chemical synergistic treatment of tumors.

The invention discloses a photo-thermal carbon dot compound capable of generating carbon free radicals as well as a preparation method and application of the photo-thermal carbon dot compound. The photo-thermal carbon dot compound takes a carbon dot as a core, a free radical initiator AIPH is modified through a surface coupling strategy, and photo-thermal and carbon free radical synergistic treatment is achieved. The preparation method comprises the following steps: thermally synthesizing carbon dots (CDs) by using a urea / citric acid solvent, and carrying out EDC / NHS-mediated coupling on AIPH. The compound generates a photothermal effect under 808 nm laser and triggers AIPH to decompose and release carbon free radicals, the drug resistance of tumor heat shock protein is overcome through low-temperature thermal therapy, and the killing capacity on tumor cells is improved through combined treatment with the carbon free radicals. The material has excellent photo-thermal stability, can be expanded to photosensitizer / targeting molecule coupling, is applied to the fields of tumor photo-thermal-thermal power synergistic treatment, microenvironment regulation and control, radiotherapy sensitization and the like, and provides a new strategy for low-toxicity and high-efficiency cancer treatment.

The present application relates to the field of tumor ablation, in particular to a kind of ablation heat metering determination method based on nuclear magnetic resonance detection signal, comprising: according to the function relationship of the effective heat conduction coefficient of tissue and relative contrast determined by the multiple sets of temperature data collected by carrying out thermal ablation to tumor model;Relative contrast is determined according to the T1 signal and T2 signal of the tumor tissue and healthy tissue of patient respectively;Heat conduction coefficient is determined according to relative contrast and function relationship;The ablation heat metering required for carrying out tumor thermal ablation to patient is determined according to heat conduction coefficient.

A spiropyran modified BODIPY tumor phototherapeutic agent and a preparation method thereof, and relate to a phototherapeutic agent for tumor treatment and a preparation method thereof, the present application takes 1,1,3-trimethyl-1,3-dihydrospiro[benzo[e]indole-2,2'-chromene]-6'-formaldehyde as a functional building block, which is covalently coupled with fluoroboron dipyrromethene core through condensation reaction. Realize the integration of photothermal therapy and ROS fluorescence tracing. Utilize the efficient photothermal conversion of BODIPY and the electronic sensitive properties of closed ring spiropyran. Under near infrared light, BODIPY is used for tumor thermal ablation, and spiropyran is used for in-situ tracing by responding to promote ROS generation and fluorescence change, breaking through the traditional "treatment only, difficult to monitor" limitation. The present application effectively inhibits the generation of unstable open ring product, while retaining the original optical advantages of the two types of molecules, and still can promote the generation of active oxygen under light, and realize the fluorescence visualization tracing of active oxygen in the treatment process.

The invention discloses a minimally invasive optical fiber photo-thermal probe for tumor thermal ablation and a preparation method and system, relates to the technical field of medical instruments, and aims to solve the problems that an existing photo-thermal treatment optical fiber probe is low in photo-thermal conversion efficiency, poor in temperature controllability, insufficient in biocompatibility and stability and difficult to adapt to high-power laser input. According to the technical scheme, a functional section is located at one end of a multimode optical fiber; the functional section further comprises a tail end tapering part, a polishing and etching part and a twisting part which are sequentially arranged from left to right, the exterior of the functional section is further coated with a packaging pipe, and a filling material is arranged between the packaging pipe and the functional section; by means of the collaborative design of twisting-tapering-etching composite structure optical fiber and medical needle tube packaging, the light field constraint and energy coupling efficiency are enhanced through a composite structure, the heat convergence effect of a needle tube is combined, precise photothermal conversion under high-power laser is achieved, stable output within the cancer cell lethal temperature range of 40-65 DEG C is achieved, and the cancer cell death rate is increased. And the clinical requirements of photo-thermal treatment are met.

This invention belongs to the field of hyperthermia equipment control technology, and particularly relates to a deep-conversion phased array focused tumor hyperthermia method and system. During the radio frequency emission pause, backscattered signals containing tissue dielectric mutation characteristics are acquired. A coherent crosstalk assessment matrix is ​​constructed, and a residual compensation phase sequence is extracted to reshape the coherent superposition of the beam in the target area. The deviation between the planned and actual temperature rise rate in the target area is converted into a global power boost compensation coefficient through nonlinear logarithmic mapping to smoothly compensate for energy drops. The standing wave ratio (VSWR) of each channel is monitored in real time, and a piecewise exponential penalty mechanism is used to calculate the safety tolerance factor. The power reduced from high-risk channels is weighted and allocated to safe channels to maintain a constant total energy flux. This invention improves the focus accuracy in heterogeneous target areas, effectively suppresses thermodynamic oscillations, and safely avoids the risk of hardware power amplifier damage.

The utility model discloses an intracranial tumor thermal therapy hood, which belongs to the field of medical instruments and comprises a rotating structure fixedly arranged on the end face of a bed board, a thermal therapy hood body is fixedly mounted on the rotating structure, a supporting structure is mounted on the inner wall of the thermal therapy hood body, a headrest is mounted on the supporting structure, and the rotating structure is fixedly connected with the supporting structure. The supporting structure comprises a supporting plate fixedly installed on the inner wall of the bed board, and the supporting plate is rotationally connected with a bidirectional lead screw through a bearing. By arranging the supporting structure, the two arc-shaped plates wrap the cheeks on the two sides of a patient, it is guaranteed that the head of the patient is in the straightening position, the distance between the two arc-shaped plates is adjusted, effective adjustment and fixation can be conducted according to the size of the head of the patient, and the problem that when an existing intracranial tumor thermal therapy hood treats a patient with blurred consciousness, the head is not prone to falling off is solved. The problems that a patient cannot control and straighten the head by himself or herself and cannot be effectively fixed according to the size of the head of the patient are solved, and the treatment effect of the thermal therapy hood on the patient is improved.

The application provides a liver cancer incomplete radiofrequency ablation mouse model and a construction method and application thereof. The method comprises the following steps: S1. Injecting a liver cancer cell suspension into a mouse, so that the liver cancer cells form tumors in the mouse; and S2. Implementing local radiofrequency ablation on the mouse with tumors formed in vivo, to obtain a liver cancer incomplete radiofrequency ablation mouse model. The liver cancer incomplete radiofrequency ablation mouse model obtained by the method provided by the application can simulate the biological process after tumor thermal ablation, overcome the difficulty that the tumor microenvironment is difficult to completely simulate in vitro, and can be directly used for researching the adaptation of liver cancer and the influence on the liver cancer microenvironment, thereby providing an important scientific basis for the research on the progress after liver cancer ablation.

The application discloses a variable frequency radiator array structure. The device comprises a plurality of low-frequency dipole antenna units with a working frequency lower than 433 MHz, which are arranged along an elliptical or quasi-elliptical track to form a radiator array. By independently regulating the amplitude (or power) and phase of the input signals of each antenna unit, the electromagnetic energy generated by the radiator array can be focused in a predetermined target area of deep tissues of a human body, and the size of the focus spot can be regulated by regulating the working frequency. A water bag filled with deionized water is installed on the inner side of the device, and the energy penetration efficiency of the array radiator is improved through impedance matching, while the body surface temperature is kept constant to prevent high-heat burns. The system can realize non-invasive and tunable deep targeted heating, and is suitable for medical fields such as tumor hyperthermia, and has the advantages of large penetration depth, accurate focusing and high safety.

The invention discloses a laser ablation device for minimally invasive tumor treatment. The laser ablation device comprises an ablation assembly. The ablation assembly comprises a laser optical fiber, an optical fiber tube and a laser needle arranged at one end of the optical fiber tube, the optical fiber tube is sleeved with an outer sleeve connected with the laser needle, the end, away from the laser needle, of the outer sleeve is connected with a one-way tee joint, and one input end of the one-way tee joint is provided with an injection tube communicated with the injection channel. When the laser ablation device is used, the optical fiber tube is connected with the laser generator, then the laser generator is started for laser ablation, and the temperature change of the ablation range is monitored through the temperature sensor module in the ablation process; when the temperature exceeds the preset temperature, normal saline can be continuously injected, so that the temperature of the operation area is controllable; the tumor thermal ablation operation can be ensured in a short time, the complications and the bleeding amount of the operation are greatly reduced, and the high practical value is achieved.

This invention discloses a non-destructive temperature measurement method based on the sound absorption coefficient. It involves using an ultrasonic probe to emit ultrasonic pulses that strike a sample through a medium (pure water) at different temperatures, generating echoes. The relationship between acoustic parameters such as sound velocity and echo energy and temperature is determined by analyzing the time-shift and amplitude changes of the echoes at different temperatures. The sound absorption coefficient is inversely proportional to the cube of the sound velocity and the echo amplitude. The sound absorption coefficient is calculated using a formula, and its correlation curve with temperature is fitted. This curve is then compared with the correlation curve of measured echo energy versus temperature for verification. This method offers higher accuracy and is more suitable for non-invasive temperature measurement in tumor hyperthermia.