30 results about "Oncothermia" patented technology

The invention relates to a gastric cancer lymph node staining pathological image automatic recognition system based on a deep neural network, and the system comprises a first module which removes a background region of a slice image, and extracts a tissue region as a region of interest; a second module which is used for cutting the slice image into small imagesand inputting the small images into adeep neural network, wherein the deep neural network comprises a first unit, a second unit, a third unit, a fourth unit and a fifth unit, the first unit is used for calculating a tumor probability score of each small image; the second unit synthesizes a tumor thermodynamic diagram of the whole tissue slice image according to the tumor probability scores of the plurality of small images; the thirdunit binarizes the tumor thermodynamic diagram to generate a monochrome mask diagram, the fourth unit uses median filtering to remove false positive points, and the fifth unit is used for calculatingthe number of positive points in the whole mask graph. The system can automatically identify the slice image of the gastric cancer metastatic lymph node, and can improve the efficiency of the diagnosis process in histopathology.

The method for simulating the heat field distribution of the microwave coagulation treatment of liver tumors in the invention is a simulation measurement method of the heat field distribution during the microwave coagulation treatment of liver tumors. Including 1), the pre-experiment on the isolated pig liver, it is found that the single embedded microwave wireless is symmetrically distributed in the r direction and the θ direction: 2) making a two-dimensional simulation measurement device for the microwave radiation field, 3) placing the microwave antenna Put it into the two-dimensional analog measurement device, and set the measurement thermocouple at the corresponding position. The thermocouple is connected to the data collector, and the latter is connected to the computer. 4), the tissue microwave phantom is blanked in the two-dimensional analog measurement device, ), measuring the temperature change with time at the position where the thermocouple is set for microwave radiation of different energies, and substituting the data into the biological heat transfer equation to obtain the microwave radiation energy SAR per unit volume and unit time, and substituting the SAR into its distribution function equation , by solving this simultaneous equation with a computer, the coefficients of the distribution function equation can be obtained, and the distribution function of the three-dimensional thermal field of microwave radiation can be obtained, so that the temperature at a specified point at a specified time can be obtained.

The invention relates to a method for passively regulating the temperature field of biological tissues based on optical phase-change nanoparticles, which relates to the technical field of tumor photothermal therapy. The purpose of the present invention is to solve the problem of how to reduce the damaged range of normal biological tissues while ensuring the effectiveness of thermal therapy in tumor photothermal therapy. Method: Calculate the absorption factor Q of qualified nanoparticles before and after phase transition abs With the change of the laser wavelength, further select the nanoparticles that meet the requirements; calculate the change of the absorption factor of the nanoparticle surface coating before and after the phase transition with the laser wavelength, and select the nanoparticles that meet the requirements again; calculate the quality factor P of the nanoparticles , select the nanoparticle with the largest quality factor as the phase change material required for laser-induced tumor hyperthermia. The invention can obtain a passive regulation technology of the biological tissue temperature field based on the optical phase change nanoparticles.

The invention belongs to the technical field of medical instruments, and particularly relates to a blood tumor thermal therapy device. The blood tumor thermal therapy device comprises a bottom plate,a telescopic plate, a base, a telescopic rod, a supporting frame, a bed plate, a transverse rod, a connecting ring and a connecting piece, wherein the bottom of bottom plate is connected with base; the left side and the right side of bottom plate are connected with the telescopic plate, and telescopic rod is installed at top of base; the bottom of the supporting frame is connected with the telescopic rod; the top of the supporting frame is connected with the bed plate; the supporting rod is installed at the top of the telescopic plate; the connecting ring is installed on the outer wall of thesupporting rod; the connecting piece is installed on the connecting ring; and the cross rod is connected with the connecting piece. According to the blood tumor thermal therapy device, the transverserod installed outside the thermal therapy device and a sliding groove formed in the outer portion of the thermal therapy device are fixed through a rotating heat isolation pad and other equipment, sealing operation is carried out on the periphery of the bed plate, and then thermal therapy is carried out, so that the influence on the external environment can be effectively reduced, meanwhile, the use range of the thermal therapy device is widened, and operation is convenient.

The invention discloses a magnesium-zinc ferrite for tumor hyperthermia and a preparation method thereof, and belongs to the crossing field of material science and biomedicine. The magnesium-zinc ferrite Mg(1-x)ZnxFe2O4 (x is not less than 0.1 and not greater than 0.9) has a particle diameter of 20-100 nm; molar percentages of Mg<2+> and Zn<2+> in the magnesium-zinc ferrite are 90-10 mol% and 10-90 mol%, respectively. The preparation method provided by the invention is simple and does not require expensive equipment; in addition, the prepared magnesium-zinc ferrite has good magnetic propertiesand magnetocaloric properties, can be heated within a range of 43-50 DEG C or heated to 60 DEG C or higher rapidly under induction of an external magnetic field with a frequency of 215 kHz, and is predictably applied to the tumor hyperthermia, so that the magnesium-zinc ferrite provided by the invention has excellent industrial application prospects and practical application values.

The invention discloses a three-dimensional tumor thermal ablation instrument and a control method thereof. The three-dimensional tumor thermal ablation instrument is mainly used for heating a tumor through a heating device, monitoring the temperature change of normal tissues around the tumor through a temperature measuring needle, controlling the heating temperature through a control instrument, monitoring the temperature value of the normal tissues at the same time, inactivating the tumor without damaging the normal tissues, and treating the tumor.

The invention discloses a tumor thermal ablation device based on non-contact power supply. The device includes: an electromagnetic generating device, a transmitting coil, a receiving coil and an electric heating element; the output end of the electromagnetic generating device is connected with the transmitting coil, and the electromagnetic generating device is used to generate electromagnetic energy and transmit the electromagnetic energy to the transmitting coil; the receiving coil is connected to the transmitting coil Coils are arranged correspondingly to receive electromagnetic energy emitted by the transmitting coil and convert the electromagnetic energy into electrical energy; the output end of the receiving coil is connected to the electric heating element; when tumor thermal ablation is performed, the electric heating element is arranged in the tumor area to be treated. The tumor thermal ablation device based on non-contact power supply of the present invention adopts non-contact power supply technology, directly introduces electric energy to the tumor tissue site, and realizes thermal ablation of tumor tissue through temperature-controlled heating of electric heating elements; accurate positioning can be realized within the minimally invasive scale , Good conformability, uniform and adjustable thermal field distribution, less trauma to the human body, and less damage to normal tissues.

The invention discloses a tumor thermotherapy device based on an implanted coil and a parameter optimization method thereof. In traditional tumor magnetic-mediated thermotherapy, it is necessary to inject heat-producing magnetic particles into the human body; and as the particles diffuse, the effect of hyperthermia decreases. The invention relates to a magnetically mediated hyperthermia device for tumors based on implanted coils, which includes internal coils and external coils. The extracorporeal coil is an open-loop single-turn circular coil. The internal body coil is a closed-loop single-turn circular coil. The radii of the external coil and the internal coil are r 1 and r 2 , the line radius is r w1 and r w2 . Among them, d is the wireless transmission distance. The invention can achieve the effect of sustainable hyperthermia on tumors.

The invention discloses an APD hybrid nano system and its construction method and application. The hybrid system is obtained by mixing and incubating nano-gold rods modified with thiol-containing cationic polymers and left-handed DNA tetrahedrons. The invention uses unmodified DNA, avoids the use of expensive thiol DNA, and is more conducive to reducing the cost of nanoscale drug carriers. The inventors have discovered and proved through experiments that the use of left-handed DNA can resist ribozyme degradation, and at the same time, after the polymer and DNA are compounded, the DNA can be protected, and the dual functions improve the stability of the system. The APD hybrid nanosystem also has the ability to enter cells efficiently. It can be used to load drugs, especially chemotherapy drugs, and has application prospects in the field of combined therapy of tumor hyperthermia and chemotherapy.

The invention relates to an access door or a stand and an antenna assembly for a therapy device or for an imaging device, in particular for a tumor thermotherapy system. In particular, said assembly comprises an access door or platform (2); an array of first antennas (3) connected to said platform (2); a bed (4), said bed being at least movable relative to said platform a frame (2) that moves longitudinally; and at least one second antenna (4A) disposed within said bed, wherein said assembly includes a lifting device (2A) for lifting said access door or platform.

The invention provides application of a thermosensitive material in preparation of an injection for protecting an organ peripheral structure in thermal ablation. The thermosensitive material is used for protecting an organ peripheral structure when a mammal abdominal solid organ is adjacently subjected to thermal ablation by a membrane tumor. The injection material is in a liquid state with good fluidity at a temperature of 0-4 DEG C or 10-22 DEG C, and is converted from liquid phase to solid phase or semi-solid phase without fluidity when the temperature is increased to 34-37 DEG C, so as to be able to stay in the injection position; and optimally, the injection material is converted into solid phase or semi-solid phase without fluidity within 10 seconds to 3 minutes. The injection prepared from the thermosensitive material is used for intraperitoneal injection instead of a conventional injection, so that an organ is separated from the peripheral structure which is easily injured by heat, an enough protecting thickness can be achieved, the thermal ablation can be safe, and the defects of large fluidity, short staying in a target region, durable perfusion requirement and the like of a conventional liquid.