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Nano-hydroxyapatite/polycaprolactone gradient functional material prepared through induction of high-voltage electrical field and preparation method thereof

A technology of nano-hydroxyapatite and gradient functional materials, which is applied in medical science, tissue regeneration, prosthesis, etc., to achieve the effect of good toughness and environmental protection during processing

Active Publication Date: 2017-07-07
JIANGHAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The invention provides a nano-hydroxyapatite / polycaprolactone gradient functional material induced by a high-voltage electric field and a preparation method thereof, which solves the technical problem of how to prepare a gradient composite material similar to the microscopic appearance of bone tissue, and achieves The technical effect of nano-hydroxyapatite / polycaprolactone gradient functional materials obtained with gradient distribution along the direction of electric field movement

Method used

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  • Nano-hydroxyapatite/polycaprolactone gradient functional material prepared through induction of high-voltage electrical field and preparation method thereof
  • Nano-hydroxyapatite/polycaprolactone gradient functional material prepared through induction of high-voltage electrical field and preparation method thereof
  • Nano-hydroxyapatite/polycaprolactone gradient functional material prepared through induction of high-voltage electrical field and preparation method thereof

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[0032] This application provides a preparation method of nano-hydroxyapatite / polycaprolactone gradient functional material induced by high-voltage electric field, figure 1 It is a flow chart of the preparation method of nano-hydroxyapatite / polycaprolactone gradient functional material induced by high-voltage electric field in the preferred embodiment of the present application, figure 2 The principle diagram of the preparation method of the nano-hydroxyapatite / polycaprolactone gradient functional material induced by high-voltage electric field for the preferred embodiment of the application; please refer to figure 1 with figure 2 , the preparation method comprises:

[0033] Step S110, dissolving polycaprolactone (PCL), a biocompatible and degradable polymer matrix, in an organic solvent;

[0034] Wherein, the organic solvent in the step S110 is one or more of toluene, tetrahydrofuran, ethyl acetate, dichloromethane, chloroform and dioxane.

[0035] Step S120, adding hydro...

Embodiment 1

[0046] S1, 10g PCL was dissolved in organic solvent 100ml toluene at 70°C;

[0047] S2, adding 0.1g HA to the solution;

[0048] S3, use an ultrasonic disperser with a power of 1000W to disperse for 30 minutes, and remove 80% of the solvent under reduced pressure at 70°C;

[0049] S4, the remaining paste is dried in a freeze drying oven at -4°C for 4 hours to remove the remaining solvent;

[0050] S5, crush the HA / PCL mixture with a pulverizer and pour it into a grinding tool, and heat press it at 150°C / 10MPa to form a sample with a thickness of 1mm.

[0051] S6, the DC electric field drives the HA / PCL melt to form a gradient structure; put the hot-pressed sheet into a 1mm thick, metal conductive mold at the bottom, and put the mold on a heating table with adjustable temperature. After applying a DC voltage of 800V, the sample was maintained at 80°C for 1 hour, then the temperature was lowered to room temperature, and the electric field was removed. After cooling, the sample...

Embodiment 2

[0053] S1, 10g PCL was dissolved in 100ml dioxane at 70°C;

[0054] S2, adding 0.5g HA to the solution;

[0055] S3, use an ultrasonic disperser with a power of 1000W to disperse for 30 minutes, and remove most of them under reduced pressure at 70°C;

[0056] S4, the remaining paste is dried in a freeze drying oven at -4°C for 4 hours to remove the remaining solvent;

[0057] S5, crush the HA / PCL mixture with a pulverizer and pour it into a grinding tool, and heat press it at 150°C / 10MPa to form a sample with a thickness of 1mm.

[0058] S6, a gradient structure is formed under the drive of a DC electric field; the hot-pressed sheet is put into a mold with a thickness of 1 mm and a metal conductive sheet at the bottom, and the mold is placed on a heating table with adjustable temperature. After applying a DC voltage of 800V, the sample was maintained at 100°C for 1 hour, then the temperature was lowered to room temperature, the electric field was removed, and the sample was ...

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Abstract

The invention discloses a nano-hydroxyapatite / polycaprolactone gradient functional material prepared through induction of a high-voltage electrical field and a preparation method thereof. The preparation method comprises the following steps: dissolving polycaprolactone (PCL) as a biocompatible and degradable polymer matrix in an organic solvent; adding hydroxyapatite (HA) into an organic solution; dispersing for 30min by using an ultrasonic disperser with the power of 1000W, and removing 65-90% of the solvent under reduced pressure; pulverizing an HA / PCL mixture by using a pulverizer, pouring into a grinding device, performing hot press moulding at 150 DEG C and 10 MPa to form a HA / PCL melt having the sample thickness of 1-3mm; driving the HA / PCL melt by using a DC electrical field to form a gradient structure. According to the invention, the technical problem of how to prepare a gradient composite material similar to micromorphology of a bone tissue is solved.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a nano-hydroxyapatite / polycaprolactone gradient functional material induced and prepared by a high-voltage electric field and a preparation method thereof. Background technique [0002] Gradient functional material refers to a heterogeneous composite material in which the composition, structure and other constituent elements of the material change continuously in a certain direction of the material, so that the performance of the material also changes continuously. For the polymer gradient system filled with inorganic particles, the preparation methods of gradient functional materials are mainly divided into two categories: the first category uses the homogeneous mixture solution suspension system of the two as the initial system, and uses a medium between the particles and the polymer matrix. The density, weight or difference of the force field, magnetic field, or electric ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/18A61L27/50
CPCA61L27/12A61L27/18A61L27/50A61L2430/02C08L67/04
Inventor 刘学清刘继延陈佳邹立勇胡成龙彭潘瑞张畅
Owner JIANGHAN UNIVERSITY
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