Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of triacetyl-3-hydroxyphenyladenosine in preparation of medicine for prevention or treatment on non-alcoholic fatty liver

一种羟基苯基腺苷、三乙酰基的技术，应用在医药领域，能够解决毒副作用大、疗效欠佳等问题，达到毒副作用小、疗效显著、使用安全的效果

Pending Publication Date: 2017-07-14
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI +1
View PDF5 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is still a lack of specific drugs. Commonly used statins, fibrates and other blood lipid-lowering drugs have poor efficacy and relatively large toxic and side effects.
There is no report on the application of this compound in the prevention or treatment of non-alcoholic fatty liver

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of triacetyl-3-hydroxyphenyladenosine in preparation of medicine for prevention or treatment on non-alcoholic fatty liver
  • Application of triacetyl-3-hydroxyphenyladenosine in preparation of medicine for prevention or treatment on non-alcoholic fatty liver
  • Application of triacetyl-3-hydroxyphenyladenosine in preparation of medicine for prevention or treatment on non-alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Application of triacetyl-3-hydroxyphenyladenosine (IMM-H007) in the treatment of non-alcoholic fatty liver

[0036] 1. Experimental materials

[0037] 1. Reagents

[0038] OCT frozen section embedding agent, American cherry; pentobarbital sodium, sigma company; PEG6000, sigma company; glycine, sigma company; paraformaldehyde, Sinopharm Reagent Co., Ltd.; oil red O, sigma company; HE staining solution, Taiwan Beso Company; Total Cholesterol (TC) Detection Kit, Japan Sekisui Medical Technology (China) Co., Ltd.; Total Triglyceride Detection Kit, Zhongsheng Beikong Biotechnology Co., Ltd.; Free Fatty Acid Detection Kit, Japan Sekisui Water Medical Technology (China) Co., Ltd. Alanine aminotransferase (AST / ALT) test kit, Nanjing Jiancheng Institute of Bioengineering; Aspartate aminotransferase (AST / GOT) test box, Nanjing Jiancheng Bioengineering Institute;

[0039] 2. Instrument

[0040] Multi-purpose low-temperature high-speed centrifuge, Eppendorff, Germany...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of triacetyl-3-hydroxyphenyladenosine, represented as the formula (I), in preparation of medicine for prevention or treatment on non-alcoholic fatty liver, wherein the triacetyl-3-hydroxyphenyladenosine can significantly reduce levels of AST, ALT and TG in serum, significantly improves liver functions and reduces degree of fatty liver, and has significant curative effect and low toxic and side effects in prevention or treatment on the non-alcoholic fatty liver.

Description

technical field [0001] The invention relates to the application of triacetyl-3-hydroxyphenyl adenosine and a pharmaceutical composition containing it in the preparation of drugs for preventing or treating non-alcoholic fatty liver, belonging to the technical field of medicine. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) refers to a group of clinicopathological syndromes characterized by hepatic parenchymal cell damage and fat accumulation caused by excessive drinking and other definite causes of liver damage. A metabolic stress-induced liver injury closely related to insulin resistance (insulin resistance, IR) and genetic susceptibility, its pathological changes are similar to alcoholic liver disease, but the patient has no history of excessive drinking. Its components include nonalcoholic simple fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver fibrosis, nonalcoholic fatty liver cirrhosis and its related liver canc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61P1/16
CPCA61K31/7076A61P1/16
Inventor 朱海波史会杰
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI