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A kind of thickener and its application for improving the stability of oral composition containing zinc salt

An oral composition and thickener technology, applied in the field of oral care, can solve the problems of easy degradation of the thickener, water separation of the toothpaste, and instability of the toothpaste, so as to improve the electrolyte resistance, increase the stiffness, improve the The effect of tolerance

Active Publication Date: 2020-06-09
广州舒客实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Toothpaste thickeners are easily affected by electrolytes (such as Cl - , Fe 2 + , Zn 2+ etc.), some thickeners with poor salt tolerance are prone to degradation, resulting in water separation in the toothpaste paste
Adding higher doses of zinc salts to toothpaste will accelerate toothpaste instability and severe water separation during the shelf life

Method used

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  • A kind of thickener and its application for improving the stability of oral composition containing zinc salt
  • A kind of thickener and its application for improving the stability of oral composition containing zinc salt
  • A kind of thickener and its application for improving the stability of oral composition containing zinc salt

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A thickener for improving the stability of oral compositions containing zinc salts, comprising sodium carboxymethylcellulose and xanthan gum, the degree of substitution of sodium carboxymethylcellulose is 1.0 to 1.1; the carboxymethylcellulose The mass ratio with xanthan gum is 3:7. Carboxymethyl cellulose has a viscosity of 1100mPa.s.

[0027] In parts by weight, the components of the toothpaste are as follows:

[0028]

[0029] Toothpaste prepared as follows:

[0030] (1) adding sodium saccharin and sodium benzoate into water and stirring to dissolve;

[0031] (2) Add thickener and PVM / MA copolymer into sorbitol and stir evenly, add PEG-400 and stir evenly;

[0032] (3) Add the homogeneous solution of step (2) to the solution of step (1) and stir evenly;

[0033] (4) zinc citrate is added in the solution of step (3) and stirred;

[0034] (5) Sodium lauryl sulfate is added in the hydrated silica and stirred evenly;

[0035] (6) Add the uniform powder of step (5)...

Embodiment 2

[0039] A thickener for improving the stability of oral compositions containing zinc salts, comprising sodium carboxymethylcellulose and xanthan gum, the degree of substitution of sodium carboxymethylcellulose is 1.0 to 1.1; the carboxymethylcellulose The mass ratio with xanthan gum is 7:3. Carboxymethyl cellulose has a viscosity of 1100mPa.s.

[0040] In parts by weight, the components of the toothpaste are as follows:

[0041]

[0042] Adopt the method for embodiment 1 to make toothpaste. The high temperature was 45°C for 7 days, 15 days, 1 month, 2 months, and 3 months respectively. The stability results are shown in Table 1.

Embodiment 3

[0044] A thickener for improving the stability of an oral composition containing zinc salt, comprising sodium carboxymethylcellulose, xanthan gum and propolis, the degree of substitution of sodium carboxymethylcellulose is 1.0-1.1; the carboxymethyl The mass ratio of cellulose, xanthan gum and propolis is 1:1:1 sodium carboxymethyl cellulose, and its viscosity is 1100mPa.s.

[0045] In parts by weight, the components of the toothpaste are as follows:

[0046]

[0047] Adopt the method for embodiment 1 to make toothpaste. The high temperature was 45°C for 7 days, 15 days, 1 month, 2 months, and 3 months respectively. The stability results are shown in Table 1.

[0048] The present invention is to verify the effect of the thickener of the present invention, specially set up the comparative verification of comparative example, verification experiment is as follows:

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Abstract

The invention discloses a thickener for improving stability of an oral composition containing zinc salts and application of the thickener; the thickener comprises sodium carboxymethyl cellulose and xanthan gum; the degree of substitution of the sodium carboxymethyl cellulose is 1.0 to 1.1; the mass ratio of the sodium carboxymethyl cellulose to the xanthan gum is 3:7 to 7:3. The sodium carboxymethyl cellulose of specific degree of substitution is blended with xanthan gum, the ability of toothpaste to tolerate electrolyte is improved, and the stability of the toothpaste is improved. The toothpaste with high content of added zinc salts has good stability, and the toothpaste never becomes watery and thick within the shelf life.

Description

technical field [0001] The invention relates to the technical field of oral care, in particular to a thickener for improving the stability of an oral composition containing zinc salt and an application thereof. Background technique [0002] It has been reported in the literature that zinc ions have anti-plaque, anti-calculus and anti-gingivitis effects. At present, some oral care products on the market that promote anti-plaque and anti-calculus all add a certain amount of zinc salt. Numerous patents also disclose oral compositions containing zinc salts. details as follows: [0003] The patent "Zinc Citrate Pellets in Oral Composition" (ZL 03809346) uses zinc citrate as an anti-calculus substance to be added to the oral composition, and the added amount of zinc salt is 0.001%-20%. The patent "A Highly Efficient Stain-Removing and Whitening Toothpaste and Its Manufacturing Method" (ZL 200510026049.5) mentions a whitening toothpaste with a ratio of 0.5%-3.5% zinc citrate. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/73A61K8/27A61Q11/00
CPCA61K8/27A61K8/73A61K8/731A61K2800/592A61Q11/00
Inventor 陈敏珊李林陶丽闫素贞
Owner 广州舒客实业有限公司