Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of immunoenhancing traditional Chinese medicine composition and preparation method thereof

A technology of immune enhancement and composition, applied in the field of medicine, can solve the problems of no reported high-efficiency and no-side effect immune enhancer, rarely seen use of fungal drugs, etc., and achieve the effect of enhancing antibody titer and enhancing immunity.

Inactive Publication Date: 2020-09-25
BOZHOU UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Fungi are widely used in the development of antibiotics, but the current immune enhancers of traditional Chinese medicine mainly use herbal medicines, and there are few reports on the use of fungal medicines, let alone the combination of fungal medicines and herbal medicines for clinical use with high efficiency and no side effects. Composition of immune enhancer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of immunoenhancing traditional Chinese medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Preliminary screening of Chinese herbal medicines

[0039] Experimental animals:

[0040] Mice, male, healthy Kunming rat.

[0041] Test items and test methods:

[0042] The immune system of animals (including humans) mainly includes specific immunity and nonspecific immunity, among which the humoral immunity supported by B cells and the cellular immunity supported by T cells are mainly in the specific immunity, and the natural killer cells (natural killer cells) are important in the nonspecific immunity. NK cells).

[0043] B cells secrete various antibodies, among which the IgG content is the highest. Therefore, the present invention uses the IgG content to evaluate the humoral immunity.

[0044] T cells secrete various interleukins, among which IL-2 is one of the most important interleukins. Therefore, the present invention uses the content of IL-2 to evaluate the situation of cellular immunity.

[0045] NK cells secrete various cytokines, among which ...

Embodiment 2

[0070] Embodiment 2: prescription of traditional Chinese medicine

[0071] According to the data shown in Table 1, the first three herbal medicines and fungal medicines were used for formulating prescriptions, and one herbal medicine was used to form nine prescriptions.

[0072] Adopt the experimental method parallel with embodiment 1 below, only Chinese medicine used is composition, and wherein in every feeding of every kind of Chinese medicine, each component is 50mg, and other methods and conditions are identical with embodiment 1. The specific components of the formula are as follows:

[0073] The data of the above-mentioned groups of tests are shown in Table 2.

[0074] See Table 2 for relevant test data. In order to facilitate observation and comparison. Table 2 lists the data of the control and single drug in Table 1.

[0075] Table 2

[0076] group IgG (mg / ml) IL-2 (pg / ml) IFN-γ (pg / ml) Control 1 8.36 25.68 450.28 Control 2 3.57 9.25 ...

Embodiment 3

[0081] Embodiment 3: prescription of traditional Chinese medicine

[0082] Codonopsis + white bald puffball is used as the basic drug prescription of the herbal medicine and fungal medicine prescription of the present invention, and then try to add other traditional Chinese medicine materials on this basis. The test method is the same as in Example 2, except that the raw materials of the medicinal materials used are different.

[0083] On the basis of Codonopsis Codonopsis + White Bald Puffball, other top three herbal medicines and top three fungal medicines with the best effects are added respectively.

[0084] The test results are shown in Table 3.

[0085] table 3

[0086] group IgG (mg / ml) IL-2 (pg / ml) IFN-γ (pg / ml) Control 1 8.36 25.68 450.28 Control 2 3.57 9.25 183.82 Control 3 4.60 12.54 258.73 Codonopsis + white bald puffball 10.03 38.42 597.24 Codonopsis + white bald puffball + astragalus 13.21 43.26 647.32 ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an immune-enhancing traditional Chinese medicinal composition which comprises the active medicinal raw materials of codonopsis pilosula and white puffball, and can optionally comprise one or more of astragalus membranaceus, cordyceps sinensis, wolfberries and ganoderma lucidum. The immune-enhancing traditional Chinese medicinal composition can be prepared into powder, a mixture or other conventional dosage forms. By using the composition, the concentration of IgG, IL-2 and IFN-gamma in an immunosuppressive model mice body can be effectively improved, and the valence of an antibody of a Newcastle disease vaccine can be enhanced. Therefore, the composition can be used as the traditional Chinese medicinal composition for enhancing the immunity.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an immune enhancing traditional Chinese medicine composition and a preparation method thereof. Background technique [0002] Microbial infections seriously affect the health of animals, including humans. The reproduction of pathogenic microorganisms in animals will bring diseases to animals, disrupt the body's metabolism, and produce toxins. [0003] Bactericidal drugs can kill specific pathogenic microorganisms, but the damage to the body by microorganisms mainly requires the body to recover by itself. [0004] Anti-inflammatory drugs can fight inflammation to promote the recovery of the body, but generally do not enhance the body's own resistance and immunity. [0005] Therefore, in the field of medical care, immune enhancers are needed. Immunopotentiators refer to substances that can increase the body's specific response to antigens or microorganisms through non-specific...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/344A61K36/481A61K36/815A61K9/14A61P37/04
CPCA61K9/14A61K36/06A61K36/068A61K36/074A61K36/344A61K36/481A61K36/815A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 魏磊魏文天王承民
Owner BOZHOU UNIV