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Novel composite antibacterial agent as well as preparation and application of master batches thereof

A composite antibacterial agent and a new technology are applied in the field of preparation and application of new composite antibacterial agents and their masterbatches, which can solve the problems of insolubility of chitosan and limitation of application occasions, and achieve enhanced antibacterial effect, easy processing and molding, and improved accessibility. water-soluble effect

Inactive Publication Date: 2017-08-04
马嘉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan is insoluble in water and alkaline solutions, and can only be dissolved in weak acids, which limits its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of composite antibacterial agent: add 100 g of chitosan, 80 g of monomethyl fumarate, and 2000 g of ultrapure water to the reaction kettle, magnetically stir to dissolve, and seal for reaction at 45°C for 3 hours. After natural cooling, dry weighing to obtain 168 g of bright yellow powder.

Embodiment 2

[0024] Preparation of composite antibacterial masterbatch: 150g of chitosan / monomethyl fumarate composite antibacterial agent and 600g of carboxylated polypropylene were put into a ball mill for grinding and blending for 3 minutes, and then extruded through a conical twin screw for 5 minutes. Produced into a linear shape, pelletized to prepare 700g composite antibacterial masterbatch.

Embodiment 3

[0026] Preparation of antibacterial polypropylene film: Take 300g composite antibacterial masterbatch and 3000g polypropylene resin (Z30S, Maoming Petrochemical), mix them evenly, put them into a small experimental film blowing machine, and set the temperature in three sections at 100℃, 110℃, and 110℃. The thickness of the prepared antibacterial film is 20C.

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PUM

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Abstract

The invention provides preparation of a novel composite antibacterial agent. The preparation comprises the following steps: adding chitosan, monomethyl fumarate and ultrapure water to a reactor according to a molar mass ratio of 1:1:0.2, stirring by a magnetic force for dissolution, carrying out a sealed reaction for 3 hours at the temperature of 45 DEG C, thus obtaining a bright yellow reaction solution, after natural cooling, carrying out freeze drying, dissolving an obtained solvent in distilled water, and then preparing the antibacterial solution. The invention further provides preparation and application of master batches of the novel composite antibacterial agent. The novel composite antibacterial agent can be taken as an additive, and can be used for preparing a long-acting antibiotic film and a long-acting antibacterial bottle cap. The novel composite antibacterial agent disclosed by the invention can improve the antibacterial ability of chitosan and enable the chitosan to be easily processed, and also has an excellent antibacterial effect no matter in a neutral environment or a weak alkaline environment.

Description

Technical field [0001] The invention relates to the field of antibacterial agents, in particular to the preparation and application of a novel composite antibacterial agent and its master batch. Background technique [0002] Bacterial infections are easily caused by medical devices during use, and lead to many serious consequences. Based on the mechanism of infection, people modify the surface of medical devices to achieve sterilization effects by interfering with the composition of bacterial cells. Related microbial infections mainly occur in venous catheters, tracheotomy or intubation, cardiac catheters, urethral tubes, T-tube drainage, artificial respirators, peritoneal or hemodialysis, device implantation, etc. Approximately 4 million people in my country suffer from catheter-related infections each year, with additional medical expenses reaching 10-15 billion yuan. Polymer catheter-related infections account for 30%-45% of the total number of hospital infections. The devel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F222/16C08L23/26C08L5/08C08L23/12
CPCC08F251/00C08L23/12C08L23/26C08L2203/02C08L2203/10C08L2205/03C08L5/08C08F222/16
Inventor 马嘉
Owner 马嘉
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