Preparation method of anticoagulant drugs

An anticoagulant and drug technology, which is applied in the field of anticoagulant drug preparation, can solve the problems of increased production difficulty, increased drug differentiation, insufficient color, etc., and achieve the effect of stable product process, simple and rapid process, and simple operation

Active Publication Date: 2017-08-08
TRIASTEK INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example: 1. There are many specifications for production, which increases the difficulty of production
2. Cross-contamination including batch changes
4. Increase the differentiation of medicines (different specifications are generally distinguished by different colors, if there are too many specifications, the colors are not enough, and similar colors are easy to mix), storage and transportation are more difficult

Method used

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  • Preparation method of anticoagulant drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take patient A as an example (age 21, height 170cm, weight 60kg, VKORC1 gene type A / G, CYP2C9 gene type *1 / *1, Asian race, not taking inducer drugs, taking iodominone) , Calculated, the required dose is 33.7mg per week, 4.8mg per day.

[0037] Add the pre-mixed raw and auxiliary materials to be printed in the feed hopper of the 3D printer, wherein the content of warfarin sodium is 10%, and the content of poly(vinylpyrrolidone co-vinyl acetate) (vinylpyrrolidone / vinyl acetate=6 / 4) 90%.

[0038] According to the shape (such as cube) and size (length 3mm, width 4mm, height 4mm) of pharmaceutical products, 3D modeling is carried out in the computer through computer-aided design software; the computer transmits the 3D modeling data to the 3D printer, and uses the The software performs layered slice processing and forms corresponding codes (this code is responsible for the control of X, Y, and Z sites).

[0039] Through the control of the print head of the 3D printer, the r...

Embodiment 2

[0042] Taking patient B as an example (age 30, height 180cm, weight 80kg, VKORC1 gene type A / A, CYP2C9 gene type *2 / *2, black, no inducer drugs, no iodarone), calculate So, the required dosage is 19.1mg weekly, 2.7mg daily.

[0043] Add the pre-mixed raw and auxiliary materials to be printed in the feed hopper of the 3D printer, wherein the content of warfarin sodium is 10%, and the content of poly(vinylpyrrolidone co-vinyl acetate) (vinylpyrrolidone / vinyl acetate=6 / 4) 90%.

[0044] According to the shape (such as cube) and size (3mm in length, 3mm in width, and 3mm in height) of pharmaceutical products, 3D modeling is carried out in the computer through computer-aided design software; the computer transmits the 3D modeling data to the 3D printer, and uses the The software performs layered slice processing and forms corresponding codes (this code is responsible for the control of X, Y, and Z sites).

[0045] Through the control of the print head of the 3D printer, the raw an...

Embodiment 3

[0048] Taking patient B as an example (age 30, height 180cm, weight 80kg, VKORC1 gene type A / A, CYP2C9 gene type *2 / *2, black, no inducer drugs, no iodarone), calculate So, the required dosage is 19.1mg weekly, 2.7mg daily.

[0049] Add the pre-mixed raw and auxiliary materials to be printed in the feed hopper of the 3D printer, wherein the content of warfarin sodium is 1%, and the content of poly(vinylpyrrolidone co-vinyl acetate) (vinylpyrrolidone / vinyl acetate=6 / 4) 99%.

[0050] According to the shape (such as cylinder) and size (radius 4.1mm, height 5mm) of pharmaceutical products, 3D modeling is carried out in the computer through computer-aided design software; the computer transmits the 3D modeling data to the 3D printer, and uses the built-in software Hierarchical slice processing, and form corresponding code (this code is responsible for the control of X, Y, Z position).

[0051] Through the control of the print head of the 3D printer, the raw and auxiliary material...

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Abstract

The invention provides a preparation method of Warfarin anticoagulant drugs. The method comprises the following steps: adding main materials and adjuvants to a 3D printer and conducting 3D modeling by virtue of a computer; then, transmitting 3D modeling data to the 3D printer; conducting hierarchical slicing treatment by virtue of software of the 3D printer and forming corresponding codes; squeezing the main materials and the adjuvant materials out of a nozzle in a mode of hot-melt extrusion; conducting single-layer printing through X-axle and Y-axle motion of a printing head of the 3D printer on plane; and along with layer-by-layer accumulating and mutual bonding of the printer, completing preparation of the Warfarin anticoagulant drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine and medicine production, and in particular relates to a preparation method of an anticoagulant medicine. Background technique [0002] Anticoagulant drug, also known as anticoagulant, also known as anticoagulant, anticoagulant or anticoagulant, commonly known as thin blood pill / thin blood drug, is a substance used to prevent blood clotting. It contains a variety of different drugs, the main purpose is to prevent thrombosis; secondly, when the patient needs to be connected to some medical equipment, or needs to receive blood transfusion, or his blood needs to be sent for testing, anticoagulant will also be added , so as not to coagulate the blood. Through the use of anticoagulants, diseases caused by blood clots such as deep vein thrombosis of lower extremities, pulmonary embolism, myocardial infarction and stroke can be prevented. These diseases can be fatal. The usage and dosage of anticoagul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/37A61K47/32A61K47/34A61K47/10A61P7/02B29C64/106B33Y80/00B33Y10/00
CPCA61K9/20A61K31/37A61K47/10A61K47/32B33Y10/00B33Y80/00
Inventor 李霄凌成森平邓飞黄
Owner TRIASTEK INC
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