Application of dendritic macromolecular polyamide-amine in evodiamine

A technology of evodiamine and macromolecules, applied in the field of food and medicine, can solve the problems of tissue and tissue cell membrane toxicity and side effects, and difficulty in finding absorption promoters

Inactive Publication Date: 2017-08-11
JIANGSU UNIV
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Problems solved by technology

However, in view of the diversity and complexity of the active ingredients of traditional Chinese medicine, and often compound drug administration, it is difficult to find an absorption enhancer that is effective for multiple ingredients of traditional Chinese medicine at the same...

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  • Application of dendritic macromolecular polyamide-amine in evodiamine
  • Application of dendritic macromolecular polyamide-amine in evodiamine
  • Application of dendritic macromolecular polyamide-amine in evodiamine

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Embodiment Construction

[0023] The present invention will be specifically introduced below in conjunction with the accompanying drawings and specific embodiments.

[0024] 1. Caco-2 cell model

[0025] The Caco-2 cell model is derived from human cloned colon cancer cells. It has similar structure and function to small intestinal epithelial cells. It has structures such as microvilli and related enzyme systems, so it can be used to simulate the absorption of drugs in the small intestine.

[0026] After Caco-2 cells are seeded on Transwell plates and cultured for a certain period of time, Caco-2 cells can continue to adhere to the wall, grow, divide, and differentiate, and finally form a continuous cell monolayer.

[0027] 2. Toxicity study of PAMAM Dendrimers

[0028] Thiazolium blue (MTT) colorimetric method is a common method to detect cell viability. It has been widely used in cytotoxicity experiments, biological factor activity detection, and antitumor drug screening. It is economical and sensiti...

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Abstract

The invention discloses application of dendritic macromolecular polyamide-amine in evodiamine. The dendritic macromolecular polyamide-amine has the effect of promoting absorption of insoluble traditional Chinese medicinal ingredients and is G4-generation PAMAM-co-OEG or G4-generation PAMAM-NH2, and the usage concentrations of both of them W/V is 0.1%. The dendritic macromolecular polyamide-amine has the advantages that the toxicity and absorption promoting effect of PAMAM Dendrimers are systematically researched at different levels of animals, cells and the like layer upon layer, and it is proved that the PAMAM Dendrimers can safely and effectively promote absorption of the insoluble ingredients. Therefore, the dendritic macromolecular polyamide-amine can serve an absorption promoter to be used in the fields of foods and drugs and is wide in application, high in efficiency and low in toxicity. Especially in the field of medicine, the PAMAM Dendrimers can improve the bioavailability of drugs, novel pharmaceutical excipients can be further developed, and thus the current utilization situation of traditional Chinese medicine is improved.

Description

technical field [0001] The invention relates to a new application of a substance, in particular to a new application of dendrimer polyamide-amines (PAMAMDendrimers), and belongs to the technical field of food and medicine. Background technique [0002] Dendrimers polyamide-amines (PAMAM Dendrimers) are one of the most widely studied dendrimers in recent years. They are composed of initiator cores, monomer repeating units and terminal groups. The relative molecular weight of the G0-G10 generation is 517. ~539000, molecular size 1~13nm, regular and delicate structure, internal cavity, controllable algebra and functional groups, low algebra (below G3.0) molecular configuration is relatively loose, medium algebra (G4.0~7.0) ) forms a porous spherical three-dimensional structure, and the surface of high algebra (G8.0~10.0) is almost a closed packing structure. The surface of PAMAM Dendrimers is densely covered with polar functional groups, which can interact with various biologi...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K31/519A61P35/00A61P9/00A61P37/08A61P9/12A61P31/04A61P7/10A61P29/00A61P33/10
CPCA61K47/34A61K31/519
Inventor 戈延茹曲文君董政起戚雪勇
Owner JIANGSU UNIV
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