Application of radix bupleuri liver-soothing powder to preparation of medicine for non-surgical or chemoradiotherapy treatment of breast cancer

A breast cancer, radiotherapy and chemotherapy technology, applied in the direction of drug combination, antineoplastic drugs, pharmaceutical formulations, etc., can solve problems such as poor effect, achieve the effects of inhibiting growth and proliferation, reducing economic burden, and inhibiting the ability to form clones

Inactive Publication Date: 2017-08-29
INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the therapeutic effect of Chaihu Shugan Powder combined with chemotherapy drugs and modified Chaihu Shugan Powder in the treatment of breast cancer is not good.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of radix bupleuri liver-soothing powder to preparation of medicine for non-surgical or chemoradiotherapy treatment of breast cancer
  • Application of radix bupleuri liver-soothing powder to preparation of medicine for non-surgical or chemoradiotherapy treatment of breast cancer
  • Application of radix bupleuri liver-soothing powder to preparation of medicine for non-surgical or chemoradiotherapy treatment of breast cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] In this example, the water decoction supernatant of Chaihu Shugan Powder formula was used to conduct drug sensitivity experiments on breast cancer cell lines in vitro and breast cancer tumor-bearing nude mice models in vivo. The results showed that the water decoction of Chaihu Shugan Powder formula It has growth inhibitory effect on breast cancer cells and breast cancer xenografts in vitro, and it is dose-dependent. The specific results are as follows:

[0043] 1) Bupleurum Shugan San decoction inhibits the growth and proliferation of breast cancer cells:

[0044] The in vitro drug efficacy of three breast cancer cell lines (human breast cancer MCF-7, MDA-MB-231 cells and mouse breast cancer 4T-1 cell line) was evaluated using cell proliferation / toxicity assay reagent (CCK8). Breast cancer cells were cultured in DMEM medium containing 10% fetal bovine serum, and cells in the logarithmic growth phase were digested and plated in 96-well plates (4×10 3 Each / well), after...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of medicine application, in particular to application of radix bupleuri liver-soothing powder to preparation of a medicine for non-surgical or chemoradiotherapy treatment of breast cancer. Studies discover that radix bupleuri liver-soothing powder can inhibit growth and proliferation, as well as clone formation ability, of the breast cancer cells and growth of breast cancer transplantation tumors. According to the complicated etiology and pathology of breast cancer, the medicine is mainly used for dispersing the liver and rectifying qi, and promoting blood circulation to remove blood stasis, and can achieve the treatment effect through overall body conditioning. The medicine can be directly used for treating breast cancer without surgeries or chemoradiotherapy to achieve a very good anti-tumor effect, and therefore, a simple and effective treatment medicine is provided for treatment of breast cancer. Meanwhile, the medicine is a traditional Chinese medicine compound, can be widely used clinically, is small in side effect and definite in curative effect, so that the life quality of patients is improved, and the economical burden of the patients is relieved.

Description

technical field [0001] The invention relates to the technical field of medicine application, in particular to the application of Chaihu Shugan powder in the preparation of non-surgical or non-radiochemotherapy medicine for treating breast cancer. Background technique [0002] Breast cancer is a malignant tumor that usually occurs in the glandular epithelial tissue of the breast, and it is also one of the most common malignant tumors in Chinese women. Every year, the number of new breast cancer cases and deaths in China accounts for 12.2% and 9.6% of the world's respectively, and the number of patients in China continues to increase, and the age of onset is getting younger, which has seriously affected women's physical and mental health and life safety. [0003] At present, surgery, radiotherapy and chemotherapy, and personalized medicine including targeted therapy are still the main means of breast cancer treatment. Among them, postoperative complications and side effects o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61P35/00
CPCA61K36/233A61K36/236A61K36/484A61K36/65A61K36/71A61K36/752A61K36/8905A61K2236/331A61K2236/53A61K2300/00
Inventor 秦川王颖黄昊高苒杨星九李克娟张玲李彦红
Owner INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap