A skin lightening composition comprising niacinamide and ilomastat

A composition and technology of nicotinamide, applied in skin care preparations, medical preparations containing active ingredients, cosmetics, etc., can solve the problems of reducing the effective concentration and reducing the dispersion of melanin particles

Active Publication Date: 2017-08-29
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, nicotinamide is thought to reduce the effective concentration of cyclic 3'-5'-AMP, thereby reducing the dispersion of melanin granules

Method used

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  • A skin lightening composition comprising niacinamide and ilomastat
  • A skin lightening composition comprising niacinamide and ilomastat
  • A skin lightening composition comprising niacinamide and ilomastat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1: In vitro study on the inhibitory effect of nicotinamide and galadine on melanin

[0051] Material

[0052] (i) Primary human neonatal foreskin melanocytes, medium 254 and human melanocyte growth supplement-2 (Life Technologies)

[0053] (ii) Galadine (R)-N4-hydroxy-N1-[(S)-2-(1H-indol-3-yl)1-methylcarbamoyl-ethyl]-2-isobutyl - Succinamide (Sigma-Aldrich)

[0054] (iii) Nicotinamide (Sigma Aldrich)

[0055] (iv) Hexylresorcinol (Sigma Aldrich)

[0056] (v) Calcein-AM-calcein acetoxymethyl ester (Sigma Aldrich)

[0057] (vi) DMSO-dimethylsulfoxide (Sigma Aldrich)

[0058] (vii) Sodium hydroxide (Merck Specialties Pvt. Ltd.)

[0059] (viii) HEPES-(4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid, N-(2-hydroxyethyl)piperazine-N'-(2-ethanesulfonic acid) (Sigma Aldrich)

[0060] (ix) NaCl - sodium chloride (Fisher Scientific)

[0061] (x) NP40-Nonidet P 40 (USB company)

[0062] (i) PMSF-phenylmethanesulfonyl fluoride (Sigma-Aldrich)

[0063] (xii) Prot...

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PUM

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Abstract

The present invention is in the field of personal care compositions, in particular relates to skin lightening compositions. A composition that combines the cyclic adenylic acid reduction and the reduction of melanin content in melanocytes remains to be desired. It has been found that niacinamide in combination with MMP inhibitor galardin synergistically reduces melanin content in melanocytes. The invention thus relates to a composition comprising a synergistic combination of niacinamide and galardin for use in skin lightening. Thus the composition, when applied topically over an appropriate length of time in-vivo, may be used to lighten the skin, or to reduce age spots or freckles.

Description

technical field [0001] This invention is in the field of personal care compositions; in particular skin lightening compositions. Background technique [0002] Most people are concerned with the level of pigmentation in their skin. For example, someone with age spots or freckles may want the pigmented spots to be less noticeable. Others may wish to lighten skin darkening caused by sun exposure or brighten their natural skin color. In order to meet this need, many attempts have been made to develop products for reducing pigment production in melanocytes. However, the substances identified so far often have low efficacy or undesired side effects, such as toxicity or skin irritation. Accordingly, there is a continuing need for new cosmetic skin lighteners with improved overall effectiveness. [0003] Conventional skin lightening compositions are based on the use of skin lightening agents which are believed to control the dispersion of melanin or inhibit tyrosinase. These sk...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/67A61Q19/02
CPCA61K8/492A61K8/675A61Q19/02A61K2800/782
Inventor M·杜塔V·S·凯尔N·S·奈尔
Owner UNILEVER IP HLDG BV
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