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A new type of foaming agent

A foaming agent and fast technology, which can be used in aerosol delivery, preparations for skin care, medical preparations with inactive ingredients, etc. The effect of improving stability and enhancing stability

Active Publication Date: 2020-05-22
BEIJING DO-PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The obtained product has good advantages in the field of low-temperature storage, and can solve the problem that the foam prepared when tetrafluoroethane is used as a propellant is difficult to meet low-temperature storage or use

Method used

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  • A new type of foaming agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] components Dosage % (w / w) Betamethasone valerate 0.12 ethanol 57.79 Propylene Glycol 2.00 cetyl alcohol 1.10 stearyl alcohol 0.50 Tween 60 0.025 Anhydrous citric acid 0.073 potassium citrate 0.027 water 33.69 propane / butane 4.675

[0034] Mix ethanol and propylene glycol. Add betamethasone valerate, cetyl alcohol, and stearyl alcohol, and stir until dissolved and clarified to form an alcohol phase. Dissolve Tween 60, citric acid, and potassium citrate in water, stir until dissolved and clear, pour into the same container, and filter to obtain the content. Fill the content into a pressure-resistant aluminum bottle, fill with propane and butane mixed propellant, and complete the preparation.

Embodiment 2

[0036] %(w / w) 1 2 3 4 5 6 7 8 9 Clobetasol Propionate 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Absolute ethanol 50.1 48.39 50.1 53.1 56.1 49.1 56.1 56.1 50.1 glycerin 3 3 3 3 3 13 3 3 3 cetyl alcohol 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 stearyl alcohol 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.4 Tween 60 0 0.01 0.01 0.02 0.02 0.02 0.05 1 1 citric acid 0.07 0.07 0.07 0.07 0.07 0.07 0.07 0.07 0.07 potassium citrate 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 water 40.44 42.15 40.44 37.43 34.43 31.43 34.4 33.45 39.45 Tetrafluoroethane 5 5 5 5 5 5 5 5 5

[0037] organic phase preparation

[0038] Heat ethanol to about 50°C, add glycerin, cetyl alcohol, stearyl alcohol, Tween 60, stir to dissolve and clarify. Add the clobetasol propionate and stir to make the solution clear.

[0039] Aqueous phase preparation

[0040] Dissol...

Embodiment 3

[0051] components Dosage % (w / w) Terbinafine Hydrochloride 1 Ethanol (96%) 54 Propylene Glycol 6 cetyl alcohol 1.1 stearyl alcohol 0.4 Polyoxyethylene 40 stearate 0.02 citric acid 0.06 potassium citrate 0.04 water 29.38 Tetrafluoroethane 8

[0052] Mix ethanol and propylene glycol and heat to about 50°C. Add terbinafine hydrochloride, cetyl alcohol, and stearyl alcohol, stir until dissolved and clear, filter, and pour the filtrate into a pressure-resistant metal tank. Dissolve polyoxyethylene 40 stearate, citric acid, and potassium citrate in water, stir until dissolved and clear, filter, pour the filtrate into the same container, and mix it automatically to obtain the content. The content is filled in a pressure-resistant aluminum bottle, filled with tetrafluoroethane, and the preparation is completed.

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Abstract

Provided is a novel foaming agent preparation method. The foaming agent comprises 0.001%-0.04%(w / w) surfactant for foaming.

Description

technical field [0001] The invention relates to a novel preparation method of a foaming agent, which involves using a small amount of surfactant to prepare the foaming agent. Background technique [0002] Foams are solutions, emulsions, suspensions or gels dispersed in propellants, stored in pressure-resistant containers, and finally sprayed out in the form of solid foams. It is called foam when it is used in the field of medicine abroad, and it is called mousse (mousse) when it is used in the field of daily chemicals. Its main features are easy to use, low density, small shear stress, and can form a thin drug film with good body feeling after use. Excellent absorption, can guarantee the adsorption and action time of the product, but it is easy to wash and has strong adaptability. [0003] Foaming agents can be divided into non-quick-eliminating foaming agents and fast-eliminating foaming agents. In the prior art, the rapid-eliminating foaming agents generally use alcohol-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K47/06A61K8/04A61K8/31A61Q19/00A61K8/14A61K8/33A61K8/34A61K8/41A61K8/46A61K8/49A61K8/85A61K8/86A61K47/10A61K47/18A61K47/20A61K47/26
CPCA61K8/046A61K8/14A61K8/315A61K8/33A61K8/34A61K8/41A61K8/463A61K8/466A61K8/4993A61K8/85A61K8/86A61K9/122A61K47/06A61K47/10A61K47/18A61K47/20A61K47/26A61K2800/10A61Q19/00
Inventor 李鹏飞李春娟吴龙昊张严源
Owner BEIJING DO-PHARMA TECH CO LTD
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