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GDNF (glial cell line-derived neurotrophic factor)-containing medicinal composition for treating corneal epithelial damage

A technology of corneal epithelium and composition, which is applied in the field of medicine to achieve the effects of promoting proliferation, promoting damage repair, and improving compliance

Inactive Publication Date: 2017-09-08
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report that the combination of GDNF and OPG is specially used to repair corneal epithelial damage

Method used

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  • GDNF (glial cell line-derived neurotrophic factor)-containing medicinal composition for treating corneal epithelial damage
  • GDNF (glial cell line-derived neurotrophic factor)-containing medicinal composition for treating corneal epithelial damage
  • GDNF (glial cell line-derived neurotrophic factor)-containing medicinal composition for treating corneal epithelial damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 eye drops

[0040] Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:

[0041]

Embodiment 2

[0042] Example 2 eye drops

[0043] Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:

[0044]

Embodiment 3

[0045] Example 3 eye drops

[0046] Prepare eye drops according to the preparation method known in the art, and its main component and content are as follows:

[0047]

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PUM

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Abstract

The invention discloses a GDNF (glial cell line-derived neurotrophic factor)-containing medicinal composition for treating corneal epithelial damage. The medicinal composition contains GDNF (preferably human-sourced GDNF), and preferably further contains OPG (osteoprotegerin, preferably human-sourced OPG). The medicinal composition (preferably in a form of an eye drop) can not only promote the proliferation and the clonal formation ability of corneal limbal stem cells, but also can effectively promote damage repair on a corneal epithelium, including repair on sustained corneal epithelial damage, treatment to diabetic corneal lesions, treatment to neurogenic keratitis and treatment to corneal limbal stem cell deficiency.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating corneal epithelial damage (preferably corneal epithelial damage induced by diabetes). Background technique [0002] The transparency and functional integrity of the cornea depend on the normal structure and metabolism of each layer of the cornea, and the outermost corneal epithelial tissue undoubtedly plays a very important role in this. Various physical damage, chemical damage, mechanical damage, pathogenic microorganisms, endocrine and immune factors can cause corneal epithelial damage. The corneal epithelium is a physical barrier against the invasion of external pathogenic factors. The maintenance of its integrity depends on the tight junction and anchor junction between epithelial cells, cells and basement membrane, and the continuous self-renewal of epithelial cells. Damage to the corneal epithelium can affect the connection betwee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K9/08A61K9/06A61P27/02A61P3/10A61P25/00A61K38/17
CPCA61K38/185A61K9/0048A61K9/06A61K9/08A61K38/1793A61K47/34A61K47/36A61K47/38A61K47/44
Inventor 齐虹高彩凤
Owner PEKING UNIV THIRD HOSPITAL
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