GDNF (glial cell line-derived neurotrophic factor)-containing medicinal composition for treating corneal epithelial damage

Abstract

The invention discloses a pharmaceutical composition containing GDNF for treating corneal epithelial injury, the pharmaceutical composition contains GDNF (preferably human source), and preferably further contains OPG (preferably human source). The pharmaceutical composition of the present invention (preferably in the form of eye drops) can not only promote the proliferation and clone formation ability of limbal stem cells, but also effectively promote the repair of corneal epithelial damage, including the repair of persistent corneal epithelial damage, diabetic keratopathy Treatment, treatment of neurokeratitis, treatment of limbal stem cell deficiency.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating corneal epithelial damage (preferably corneal epithelial damage induced by diabetes). Background technique [0002] The transparency and functional integrity of the cornea depend on the normal structure and metabolism of each layer of the cornea, and the outermost corneal epithelial tissue undoubtedly plays a very important role in this. Various physical damage, chemical damage, mechanical damage, pathogenic microorganisms, endocrine and immune factors can cause corneal epithelial damage. The corneal epithelium is a physical barrier against the invasion of external pathogenic factors. The maintenance of its integrity depends on the tight junction and anchor junction between epithelial cells, cells and basement membrane, and the continuous self-renewal of epithelial cells. Damage to the corneal epithelium can affect the connection betwee...

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Problems solved by technology

But there is no report that the combination of GDNF and OPG is specially used to repair corneal epithelial damage

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