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Chitosan-amphiphilic ion/quaternary ammonium salt natural dressing and its preparation method and application

A technology of chitin and quaternary ammonium salts, applied in medical science, bandages, etc., can solve problems such as high crystallinity, limitation, and poor solubility, and achieve strong antibacterial activity, reduced surface energy, and high antibacterial activity.

Inactive Publication Date: 2017-09-08
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a regular ring structure in the chitin molecule and there is a strong hydrogen bond between the molecules (inside), so that its crystallinity is high, resulting in poor solubility, insoluble in water, dilute alkali, In dilute acids and general organic solvents, its application is greatly limited

Method used

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  • Chitosan-amphiphilic ion/quaternary ammonium salt natural dressing and its preparation method and application
  • Chitosan-amphiphilic ion/quaternary ammonium salt natural dressing and its preparation method and application
  • Chitosan-amphiphilic ion/quaternary ammonium salt natural dressing and its preparation method and application

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preparation example Construction

[0040] The invention discloses a preparation method of a chitin-amphiphide ion / quaternary ammonium salt natural dressing, which comprises the following steps:

[0041] Step 1, pretreatment: immerse the shells in an HCl solution with a mass percentage of 3%-8% for 3 days to prepare the pretreated shells;

[0042] Step 2, synthesis of antibacterial monomer: N-(2-(acryloyloxy) ethyl)-N,N-dimethyl is dissolved in acetonitrile (MeCN) to obtain N- (2-(acryloyloxy)ethyl)-N,N-dimethyl acetonitrile solution, and then to N-(2-(acryloyloxy)ethyl)-N,N-dimethyl acetonitrile Hexyl bromide (molar ratio: N-(2-(acryloyloxy) ethyl)-N, N-dimethylhexyl bromide = 1:1-1:1.5) was added to the solution, and the mixture was heated at 75-85°C React under vigorous stirring for 12-20 hours; the stirring speed is 50-80r / min; after the reaction is completed, use vacuum filtration to filter the mixture, and finally obtain a white solid (a) after freeze-drying, which is the antibacterial monomer N-( 2-(acr...

Embodiment 1

[0052] A preparation method of chitin-amphiphilic ion / quaternary ammonium salt natural dressing, comprising the following steps:

[0053] Step 1. Pretreatment: immerse the shells in a 5% HCl solution by mass for 3 days to prepare the pretreated shells;

[0054] Step 2, synthetic antibacterial monomer:

[0055] Dissolve N-(2-(acryloyloxy)ethyl)-N,N-dimethyl in acetonitrile (MeCN) to obtain N-(2-(acryloyloxy)ethyl) with a mass concentration of 15%. )-N, N-dimethyl acetonitrile solution, then to N-(2-(acryloyloxy) ethyl)-N, N-dimethyl acetonitrile solution, add hexyl bromide (molar ratio: N- (2-(acryloyloxy)ethyl)-N,N-dimethylhexyl bromide=1:1.2), the mixture was reacted under vigorous stirring at 80°C for 16 hours, and the stirring speed was 65r / min; the reaction was completed Afterwards, the mixture was filtered using vacuum filtration (37°C, 1 hour), and finally after freeze-drying (-20°C, 1 hour), a white solid (a) was obtained, which was the antibacterial monomer N-(2-(acr...

Embodiment 2

[0064] A preparation method of chitin-amphiphilic ion / quaternary ammonium salt natural dressing, comprising the following steps:

[0065] Step 1. Pretreatment: immerse the shells in a 3% HCl solution by mass for 3 days to prepare the pretreated shells;

[0066] Step 2, synthesis of antibacterial monomer: N-(2-(acryloyloxy) ethyl)-N,N-dimethyl is dissolved in acetonitrile (MeCN) to obtain N-(2- (Acryloyloxy)ethyl)-N,N-dimethyl in acetonitrile solution, then add N-(2-(acryloyloxy)ethyl)-N,N-dimethyl in acetonitrile solution Hexyl bromide (molar ratio: N-(2-(acryloyloxy) ethyl)-N, N-dimethylhexyl bromide = 1:1), reacted under vigorous stirring at 75°C for 20 hours, stirred The rotation speed is 50r / min; after the reaction is completed, the mixture is filtered by vacuum filtration, and finally a white solid (a) is obtained after freeze-drying, which is the antibacterial monomer N-(2-(acryloyloxy)ethyl)-N , N-dimethylhexyl-1-ammonium (ADMHA, a); the vacuum filtration temperature ...

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Abstract

The invention discloses a chitosan-amphiphilic ion / quaternary ammonium salt natural dressing and its preparation method and application. The preparation method comprises pretreating shells with an HCl solution to obtain an antibacterial monomer, preparing lyophilized shells, soaking the lyophilized shells to obtain RAFT-shell which is chitin, soaking the RAFT-shell to obtain a chitin-quaternary ammonium salt material, and soaking the chitin-quaternary ammonium salt material to obtain the chitosan-amphiphilic ion / quaternary ammonium salt natural dressing. The chitosan-amphiphilic ion / quaternary ammonium salt natural dressing has good anti-bacterial and anti-pollution effects, can promote wound healing and can provide a novel thinking and means for wound use of the natural dressing.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to a chitin-amphiphilic ion / quaternary ammonium salt natural dressing and a preparation method and application thereof. Background technique [0002] For patients with large and severe skin defects, it is urgent to quickly and effectively seal the wound by various means to prevent bacterial invasion and prevent loss of body fluids, water electrolytes and energy. Wound dressings can rebuild the skin barrier, accelerate wound healing, and prepare for later surgery. An ideal wound dressing should have the following characteristics: good mechanical properties, proper water vapor permeability and excellent biocompatibility. More importantly, infection, inflammatory response disorders, etc. will cause wound healing to slow down or even not heal. An ideal wound dressing should also be able to provide a sterile microenvironment suitable for local wound growth. And natural m...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0057A61L26/0061A61L26/0066A61L2300/208A61L2300/404C08L5/08
Inventor 周代君罗高兴邢梦秋吴军
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA