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A kind of production preparation method of Chinese medicine dispersible tablet

A technology of dispersible tablets and traditional Chinese medicine, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. Convenience to take, safe transportation and low cost

Active Publication Date: 2020-08-21
CHENGDU YONGKANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many varieties of western medicine dispersible tablets on the market, but traditional Chinese medicine, because of its many ingredients and high viscosity, is relatively poorly dispersible in water, so it is difficult to prepare dispersible tablets and is rarely used.

Method used

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  • A kind of production preparation method of Chinese medicine dispersible tablet
  • A kind of production preparation method of Chinese medicine dispersible tablet
  • A kind of production preparation method of Chinese medicine dispersible tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the preparation of Chinese medicinal material extract powder

[0026] (1) Ingredients of medicinal materials (according to the legal prescription quantity expanded 1440 times):

[0027]

[0028] (2) Extraction: put the medicinal material equally into 4 extraction tanks, add 5 times the amount of 60% ethanol, soak for 30 minutes, reflux extraction 2 times, time when boiling, 1 hour each time, the medicinal solution is filtered through the pipeline filter, Combine the filtrates.

[0029] (3) Concentration: pump the liquid medicine into a multifunctional external circulation concentrator, control the vacuum degree to no more than 0.1MPa, control the temperature at 60-80°C, recover ethanol by distillation, heat and concentrate to a relative density of 1.08 (60°C), and obtain Chinese herbal medicine extract.

[0030] (4) spray drying

[0031] The extract is pumped into the spray dryer, the flow rate of the material is controlled at 10Hz by the frequency c...

Embodiment 2

[0034] Embodiment 2: the preparation of dispersible tablet particle (A)

[0035] (1) Weighing and ingredients

[0036] Name of raw material Feed amount kg Name of raw material Feed amount kg The extract powder of embodiment 1 9.5 microcrystalline cellulose 20 sodium starch glycolate 2.7 sodium alginate 0.5 Crospovidone 8.6 Total batch feeding kg 39.7～41.3

[0037] operate:

[0038] The first step: Turn on the high-efficiency wet granulator and set the process parameters: the stirring speed is set to 65 rpm, and the cutter speed is set to 1200 rpm.

[0039] Step 2: Add 6 kg of crospovidone and the above-mentioned other materials into the wet granulator, start stirring and pre-mixing for 100-120 seconds.

[0040] Step 3: Slowly add an appropriate amount of purified water into the granulator from the hopper, and start the high-speed cutter.

[0041] Step 4: During the granulation process, observe the changes of the soft m...

Embodiment 3

[0045] Embodiment 3: the preparation of dispersible tablet particle (B)

[0046] (1) Weighing and ingredients

[0047]

[0048]

[0049] operate:

[0050] The first step: Turn on the high-efficiency wet granulator and set the process parameters: the stirring speed is set to 70 rpm, and the cutter speed is set to 1350 rpm.

[0051] Step 2: Add 40 kg of crospovidone and the above-mentioned other materials into the wet granulator, start stirring and premixing for 120 seconds.

[0052] Step 3: Slowly add an appropriate amount of purified water into the granulator from the hopper, and start the high-speed cutter.

[0053] Step 4: During the granulation process, observe the changes of the soft materials at any time. According to the changes, add a certain amount of purified water to achieve the required soft material particles, and then stir for 60 seconds to discharge.

[0054] (2) Drying: Put the wet granules into an oven and dry them at 72°C. The amount of baking trays s...

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PUM

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Abstract

The invention discloses a production and preparation method of traditional Chinese medicinal dispersion tablets and relates to a traditional Chinese medicinal principal material, a disintegrant, a filler and accessories, wherein the disintegrant contains sodium carboxy methyl starch and polyvinylpolypyrrolidone; the filler contains microcrystalline cellulose; the swelling accessories include sodium alginate and konjaku flour; the dispersion tablets are prepared from these components at a certain ratio through coordination with a special production technology, and the method includes the steps of extract powder preparation, wet granulation, crushing, addition of the disintegrant through internal and external methods and tabletting. Especially, rhizoma corydalis pain-relieving dispersion tablets are fast in disintegration, high in traditional Chinese medicine dissolution rate, convenient to take, safe in storage and transportation and low in cost.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular to a production and preparation method of a traditional Chinese medicine dispersible tablet. Background technique [0002] Dispersible tablet is a kind of tablet, which can disintegrate and disperse quickly in water to form a uniform suspension. In terms of taking methods, it can be taken orally, sucked or swallowed with water. It is convenient for storage and transportation, and it is widely used in clinical practice. For drugs with poor solubility and low bioavailability, dispersible tablets are especially suitable and are a good dosage form. The ingredients of dispersible tablets are mainly composed of disintegrants, fillers and excipients in addition to pharmaceutical ingredients. Among the ingredients of dispersible tablets, disintegrants are very important components. The main consideration is its uniform dispersibility. In order to achieve a good disintegration performance of dispers...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/66A61K47/36A61K47/32A61K47/38A61K47/46
CPCA61K9/2027A61K9/205A61K9/2054A61K9/2059A61K9/2068A61K9/2095A61K36/232A61K36/66A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 许洪王世海
Owner CHENGDU YONGKANG PHARM CO LTD