New virulence gene for severe asthenospermia, and application thereof
A technique for asthenozoospermia and pathogenic genes, which is applied in new pathogenic genes of severe asthenospermia and its application field, can solve abnormal sperm tail morphology and movement, incomplete discovery, unclear relationship between genotype and phenotype, etc. question
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Embodiment 1
[0050] Example 1 Determine the causative gene of severe asthenozoospermia.
[0051]The present invention collects cases of two twins suffering from severe asthenozoospermia in a consanguineous marriage family, and both patients are infertile. The proband was 29 years old. His parents were married to three generations of aunts and cousins. He gave birth to 3 boys and 1 girl. The elder brother gave birth to 1 child, the younger sister gave birth to two children, and the twin brothers were infertile. The proband had normal development of external genitalia, normal size of bilateral testes, and no palpable abnormality of bilateral spermatic veins. The karyotype analysis of peripheral blood was normal, and the detection of Y chromosome microdeletion showed no abnormality. No upper respiratory tract diseases such as bronchiectasis, no visceral transposition, no history of sinusitis. The average value of the three semen tests in our hospital was 2.8ml of semen volume, 27.5 million ...
Embodiment 2
[0062] Example 2 confirms the causative gene of the severe asthenozoospermia mentioned above in other cases.
[0063] The invention includes all patients with severe asthenozoospermia, and verifies that the SPAG17 gene is the pathogenic gene of severe asthenospermia. In the verification, the Sanger method was used to verify the mutation of the SPAG17 gene, which took into account the verification of samples within the family.
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