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Antiviral traditional Chinese medicine composition and preparation method and application thereof

A composition and antiviral technology, applied in antiviral agents, pharmaceutical formulations, and resistance to vector-borne diseases, can solve the problems of no direct antiviral activity data, undeveloped antiviral drugs, increased prevention of influenza A virus, and Difficulty of treatment etc.

Active Publication Date: 2017-09-22
ジアホンチャン
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zanamivir is clinically inhaled by mouth, and the drug powder is directly inhaled into the replication site of the virus (in the respiratory tract) to play a role. Local administration brings great inconvenience to clinical patients and can induce bronchospasm. It is not recommended for patients with underlying lung diseases
It is precisely because of the high variability of influenza A virus that it is difficult to prevent and treat it, so it is very necessary to explore new treatment methods with high efficiency and low toxicity
[0004] 2. As an RNA virus, Zika virus has not yet developed effective vaccines, specific antiviral drugs and treatments
[0005] 3. No effective antiviral drugs have been developed for dengue virus and chikungunya virus infection
[0011] Chinese patent application 201410607204.1 titled "A preparation method of a traditional Chinese medicine preparation for treating dengue fever" discloses a traditional Chinese medicine preparation for treating dengue fever and its preparation method. The instructions provide drug toxicity data and clinical data to prove that the Chinese medicine preparation has certain Therapeutic effect, but no direct antiviral activity data

Method used

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  • Antiviral traditional Chinese medicine composition and preparation method and application thereof
  • Antiviral traditional Chinese medicine composition and preparation method and application thereof
  • Antiviral traditional Chinese medicine composition and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0095] The Chinese medicine composition formula of embodiment 1 is as follows:

[0096] Dandelion: 320g

[0097] One hundred: 190g

[0098] Arrowhead Mushroom: 190g

[0099] Among the raw materials used, Dandelion is collected from Hebei Province, China, part of it is collected from Guangxi Province, China, and Shanzi mushroom is collected from Sichuan Province, China.

[0100] The preparation process of the Chinese medicine composition of embodiment 1 is as follows:

[0101] (1) Take 320g of dandelion and 190g of herbal medicines, add 8 times the amount of 70% ethanol to extract for 1.5 hours, then add 8 times of the amount of 70% ethanol to extract for 1 and a half hours, and combine the extracts to obtain the alcohol extract;

[0102] (2) Get the medicinal residues generated in the preparation of the ethanol extract, combine 190g Arrowhead medicinal materials, add 10 times the amount of water to extract for 2 hours, then add 10 times the amount of water to extract for 2 ...

Embodiment 2

[0109] The Chinese medicine composition formula of embodiment 2 is as follows:

[0110] Dandelion: 500g

[0111] One hundred: 400g

[0112] Arrowhead Mushroom: 400g

[0113] Among the raw materials used, Dandelion is collected from Hebei Province, China, part of it is collected from Guangxi Province, China, and Shanzi mushroom is collected from Sichuan Province, China.

[0114] The preparation process of the Chinese medicine composition of embodiment 2 is as follows:

[0115] (1) Take 500g of dandelion and 400g of herbal medicines, add 10 times the amount of 60% ethanol to extract for 1.5 hours, then add 10 times of the amount of 60% ethanol to extract for 1.5 hours, and combine the extracts to obtain the alcohol extract;

[0116] (2) Get the medicinal residues generated in the preparation of the alcohol extract, combine 400g Arrowhead medicinal materials, add 10 times the amount of water to extract for 2 hours, then add 10 times the amount of water to extract for 2 hours, ...

Embodiment 3

[0129] The Chinese medicine composition formula of embodiment 3 is as follows:

[0130] Dandelion: 450g

[0131] One hundred: 250g

[0132] Arrowhead Mushroom: 400g

[0133] Among the raw materials used, Dandelion is collected from Hebei Province, China, part of it is collected from Guangxi Province, China, and Shanzi mushroom is collected from Sichuan Province, China.

[0134] The Chinese medicine composition preparation technology of embodiment 3 is as follows:

[0135] (1) Take 450g of dandelion and 250g of herbal medicines, add 10 times the amount of 60% ethanol to extract for 1.5 hours, then add 10 times of the amount of 60% ethanol to extract for 1.5 hours, and combine the extracts to obtain the alcohol extract;

[0136] (2) Get the medicinal residues generated in the preparation of the alcohol extract, combine 400g Arrowhead medicinal materials, add 10 times the amount of water to extract for 2 hours, then add 10 times the amount of water to extract for 2 hours, filt...

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Abstract

The invention belongs to the field of drug research and development, and relates to an antiviral traditional Chinese medicine composition and a preparation method and application thereof. The composition comprises Mongolian dandelion herb, root of sessile stemona and Indian iphigenia bulb and further optionally comprises root of lobed kudzuvine, rhizome of largehead atractylodes and root of blackend swallowwort, and can be prepared into appropriate pharmaceutically acceptable drug forms as needed. The composition has high resistance activity to strains of various acute infectious diseases and has good drug safety; as in-vitro(cell) pharmacodynamic test and in-vivo experiment result proved, the composition has effective broad-spectrum antiviral effect to viruses of influenza A H1N1, H7N7 and H9N2, Zika virus, Dengue fever type I and type II viruses, Chikungunya virus and the like; in addition, the composition can be developed into an oral broad-spectrum plant compound resisting various infectious viruses, which will be the major innovative breakthrough of clinic treatment in the related disease field.

Description

field of invention [0001] The invention belongs to the field of drug research and development, and relates to a traditional Chinese medicine composition capable of resisting various strains of acute infectious viruses, in particular to a composition capable of resisting viruses such as influenza A virus, Zika virus, dengue virus and chikungunya virus. Traditional Chinese medicine composition and its preparation and application. Background of the invention [0002] Influenza A virus, Zika virus (ZIKV), dengue virus (DEN), and chikungunya virus (CHIKV) spread rapidly through mosquito coal or respiratory tract due to their common transmission routes, with strong infectivity and high mortality , pose a great threat to human health. These viruses have been studied extensively. Taxonomically, influenza A virus belongs to Orthomyxoviridae; Zika virus and dengue virus belong to Flaviviridae; Chikungunya virus belongs to Togaviridae ( Togaviridae) alphavirus (alphavirus). However...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61P31/16A61P31/14
CPCA61K36/27A61K36/284A61K36/288A61K36/488A61K36/898A61K36/904A61K2236/331A61K2236/333A61K2236/51A61K2236/53A61K2300/00Y02A50/30
Inventor 贾洪章
Owner ジアホンチャン
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