Preparation method of curcumin and phospholipid complex

A technology of curcumin phospholipids and complexes, which is applied in the directions of non-active ingredients, such as medical preparations, drug combinations, and pharmaceutical formulations, can solve problems such as poor hydrophilicity and lipophilicity, and achieve increased solubility, improved solubility, and improved stability. good effect

Inactive Publication Date: 2017-09-29
JIANGSU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The object of the present invention is, aiming at the deficiencies in the prior art, provide curcumin phospholipid complex and preparation method th

Method used

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  • Preparation method of curcumin and phospholipid complex
  • Preparation method of curcumin and phospholipid complex
  • Preparation method of curcumin and phospholipid complex

Examples

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preparation example Construction

[0017] The preparation method of the curcumin phospholipid complex of the present invention is as follows: take a certain mass ratio of curcumin and phospholipids, stir them magnetically in an organic solvent at 50°C, and after 1-3h, rotary steam, add ether to remove unreacted phospholipids , vacuum-dried or freeze-dried to remove the organic solvent to obtain the curcumin phospholipid complex.

[0018] The method for measuring the encapsulation efficiency is carried out according to the following steps: add an appropriate amount of ether to dissolve the residue obtained by rotary evaporation, and let it stand for one hour. After the precipitation no longer increases, centrifuge to take the precipitate, and dry and weigh the separated precipitate. , Calculate the encapsulation efficiency of curcumin phospholipid complex according to the following formula: encapsulation efficiency (%)=precipitated drug amount / total input drug amount×100%.

[0019] Wherein the organic solvent is...

Embodiment 1

[0027] Example 1: Weigh 100 mg of curcumin and 200 mg of phospholipids, dissolve them in 20 ml of absolute ethanol, stir magnetically in a water bath at 50°C for 3 hours, spin evaporate the organic solvent, add ether to remove unreacted phospholipids, and vacuum dry to obtain a semi-solid of phospholipid complexes.

Embodiment 2

[0028] Example 2: Weigh 50 mg of curcumin and 100 mg of phospholipids, dissolve them in 20 ml of dichloromethane, stir magnetically in a water bath at 50°C for 3 hours, spin evaporate the organic solvent, add ether to remove unreacted phospholipids, and vacuum dry to obtain a semi-solid of phospholipid complexes.

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Abstract

The invention discloses a preparation method of a curcumin and phospholipid complex and relates to the technical field of medicines and preparation thereof. The curcumin and phospholipid complex is prepared by compounding curcumin and phospholipid; the invention further discloses the preparation method of the curcumin and phospholipid complex and dissolution performance of the curcumin and phospholipid complex; the curcumin and phospholipid complex prepared by the preparation method can be used for improving the hydrophily and lipophilicity of the curcumin and improving the bioavailability of the curcumin.

Description

Technical field: [0001] The invention relates to the technical field of medicine and its preparation, in particular to a curcumin compound curcumin phospholipid complex and a preparation method thereof. Background technique: [0002] Curcumin (curcumin) is a polyphenolic substance with a relatively small molecular weight extracted from ginger plants (Curcuma longa L.), and it is generally considered to be the most effective component in turmeric. [0003] [0004] Studies have shown that curcumin has the following multiple pharmacological effects: (1) anti-inflammatory effect; (2) anti-tumor effect; (3) scavenging free radicals; (4) anti-microbial; (5) anti-cancer effect; (6) Antioxidant effect; (7) Lowering blood sugar and blood fat; (8) Protecting the nervous system of the brain. Currently, curcumin-related preparations mainly include solid dispersions, cyclodextrins, microspheres, liposomes, and some other dosage forms, such as sustained-release pellets, polyethylene ...

Claims

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Application Information

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IPC IPC(8): A61K47/54A61K31/12A61P29/00A61P35/00A61P39/06A61P31/04A61P31/12A61P3/10A61P3/06A61P25/00
CPCA61K31/12
Inventor 李红霞胡梦烨戴书昌韩姗姗王泰昊滕夕莹李雷
Owner JIANGSU UNIV
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