VEGF antibody-carrying ophthalmic thermosensitive hydrogel implant and preparation method thereof
A technology of temperature-sensitive hydrogel and thermo-sensitive hydrogel, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, antibodies, etc., can solve the problem of short half-life, increased incidence of complications, monoclonal antibody Uncontrollable drug residence time and other problems, to achieve the effect of reducing harm and side effects
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment Construction
[0017] The present invention will be described in detail below in conjunction with examples.
[0018] The present invention includes: 1. Synthesis of poly-N-isopropylacrylamide hydrogel; 2. Preparation of poly-N-isopropylacrylamide (NIPAAm) hydrogel slow-release system for VEGF antibody: Weigh 200 mg of NIPAAm water Put the gel powder in a 1.5ml balanced salt solution (BSS) measuring cylinder, stir rapidly for 2 minutes to fully dissolve the powder into a mixed solution, put the mixed solution in a water tank at 60°C for 5 minutes and cool it down, and add VEGF when it is in a gelled state Antibody 25mg, put into ice water and ice bath for 5min, obtain injectable gel-like VEGF antibody hydrogel slow-release system.
[0019] 1. Preparation of poly N-isopropylacrylamide (NIPAAm) hydrogel sustained-release system of VEGF monoclonal antibody
[0020] 1. Synthesis of poly(N-isopropylacrylamide) hydrogel
[0021] Dissolve monomer NIPAAm and cross-linking agent BIS (mass ratio 99:1...
PUM
Property | Measurement | Unit |
---|---|---|
phase transition temperature | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com