Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

VEGF antibody-carrying ophthalmic thermosensitive hydrogel implant and preparation method thereof

A technology of temperature-sensitive hydrogel and thermo-sensitive hydrogel, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, antibodies, etc., can solve the problem of short half-life, increased incidence of complications, monoclonal antibody Uncontrollable drug residence time and other problems, to achieve the effect of reducing harm and side effects

Active Publication Date: 2017-10-10
SHENYANG INSTITUTE OF CHEMICAL TECHNOLOGY
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main drawback of this method is that the residence time of the monoclonal antibody in the eye is uncontrollable, its half-life in the vitreous is short (about 3-5 days), and the drug metabolizes quickly, so repeated injections are required every 4-6 weeks, increasing The incidence of complications caused by the invasive procedure of intraocular injection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • VEGF antibody-carrying ophthalmic thermosensitive hydrogel implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] The present invention will be described in detail below in conjunction with examples.

[0018] The present invention includes: 1. Synthesis of poly-N-isopropylacrylamide hydrogel; 2. Preparation of poly-N-isopropylacrylamide (NIPAAm) hydrogel slow-release system for VEGF antibody: Weigh 200 mg of NIPAAm water Put the gel powder in a 1.5ml balanced salt solution (BSS) measuring cylinder, stir rapidly for 2 minutes to fully dissolve the powder into a mixed solution, put the mixed solution in a water tank at 60°C for 5 minutes and cool it down, and add VEGF when it is in a gelled state Antibody 25mg, put into ice water and ice bath for 5min, obtain injectable gel-like VEGF antibody hydrogel slow-release system.

[0019] 1. Preparation of poly N-isopropylacrylamide (NIPAAm) hydrogel sustained-release system of VEGF monoclonal antibody

[0020] 1. Synthesis of poly(N-isopropylacrylamide) hydrogel

[0021] Dissolve monomer NIPAAm and cross-linking agent BIS (mass ratio 99:1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
phase transition temperatureaaaaaaaaaa
Login to View More

Abstract

The invention provides a VEGF antibody-carrying ophthalmic thermosensitive hydrogel implant and a preparation method thereof, and relates to a medical preparation and a preparation method thereof. The implant is a thermosensitive hydrogel for ophthalmic injection, and the phase change temperature of the thermosensitive hydrogel is 34DEG C-35DEG C; the thermosensitive hydrogel is selected from a thermosensitive NIPAAm hydrogel and carries a VEGF antibody; and the mass concentration of a thermosensitive hydrogel solution is 10%-20%. According to the VEGF antibody-carrying ophthalmic thermosensitive hydrogel implant, an anti-VEGF monoclonal antibody drug is slowly released, a relatively noninvasive method is used, the anti-VEGF monoclonal antibody drug and a gel are uniformly mixed to prepare a gel system which presents a liquid state in vitro and quickly changes into a semisolid state when injected into eyeballs, so the drug arrives the posterior segment through the injection mode to achieve the effect of locally slow release.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to an eye temperature-sensitive hydrogel implant loaded with VEGF antibody and a preparation method thereof. Background technique [0002] Diabetic retinopathy (DR) is one of the common and serious microvascular complications of diabetes and the main cause of acquired blindness in adults. DR is characterized by neovascularization, and retinal capillary endothelial cell proliferation is a prerequisite for neovascularization. The current treatment methods for such diseases mainly include laser photocoagulation, photodynamic therapy, vitrectomy, etc., but none of these treatment methods can fundamentally solve the problem of neovascularization. [0003] In recent years, with the emergence and verification of the theory that "vascular endothelial growth factor (VEGF) is an important initiator of neovascularization", anti-VEGF monoclonal antibodies have ac...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K9/06A61K47/32A61P3/10A61P9/10
CPCA61K9/0002A61K9/0048A61K9/06A61K47/32A61K2039/505A61K2039/54C07K16/22
Inventor 李磊孟艳秋胡丹丹宁偎锋马蕾
Owner SHENYANG INSTITUTE OF CHEMICAL TECHNOLOGY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products