Hydrogel compositions, methods for preparing the same and uses thereof

A hydrogel and composition technology, applied in the field of pharmaceutical compositions, can solve the problems of inability to achieve long-term effect of symptom relief, unknown itching, side effects, etc., achieve low greasy feeling, long-term symptom relief effect, and eliminate irritation

Inactive Publication Date: 2017-10-13
CHONGQING MJ MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, no effective form of treatment is known to provide symptomatic control of pruritus in most patients
Existing medical products for patients with hypertrophic scars do not achieve ideal symptom relief and long-term results, and may cause side effects such as irritation

Method used

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  • Hydrogel compositions, methods for preparing the same and uses thereof
  • Hydrogel compositions, methods for preparing the same and uses thereof
  • Hydrogel compositions, methods for preparing the same and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] Embodiment 1: the preparation of hydrogel composition

[0169] The preparation of the PMMA-chitosan nanoparticle emulsion of 4% (w / w): According to Prof.Li, the method for preparing raw material PMMA-chitosan nanoparticle emulsion in U.S. Patent No.6573313B2, wherein used in this embodiment The number average particle size of the nanoparticles is 144nm. Purified water was added to dilute the stock nanoparticles to 4% (w / w).

[0170] Preparation of the emulsion: 1.4 g of L-menthol and 0.1 g of verdox were mixed with 1.5 g of methyl salicylate at a frequency of 40 kHz for 30 minutes using an ultrasonic generator. 2.0 g of Cremophor EL was added, and the resulting mixture was stirred gently to obtain a pale yellow solution. Then, 31.25 g of 4% (w / w) nanoparticle emulsion was added to the pale yellow solution, and vigorously stirred with a homogenizer for 5 minutes to obtain a white emulsion A.

[0171] Preparation of powder mix 1: 5.2 g of hydroxypropyl guar gum (hydr...

Embodiment 2-7 and comparative example 1-2

[0175] Prepare the hydrogel compositions of Examples 2-7 and Comparative Examples 1-2 in the same manner as Example 1, except that the content of the ingredients shown in Table 1 is changed, and the rest of the ingredients are other additives, including Preservatives, buffers, rheology modifiers and plasticizers.

[0176]

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Abstract

Disclosed are hydrogel composition, method for preparing the same and use thereof. The hydrogel composition comprises a guar gum derivative which is crosslinked, a mint-based component, water, and optionally, an amphiphilic core-shell nanoparticle having a hydrophobic core and a hydrophilic shell, wherein the amount of the mint-based component is in the range of 1-6 wt%and the amount of the water is in the range of 65-95 wt%, based on the total weight of the hydrogel composition. The hydrogel composition is safe and can provide symptomatic relief for patients with symptoms such as severe and intractable pruritus associated with hypertrophic scars. The symptomatic relief effect of the hydrogel composition is reproducible, and is independent of the etiology of the burn trauma, extent of the scarring and duration of the scar formation, while tachyphylaxis is not observed. Also disclosed is a medical device comprising the hydrogel composition.

Description

technical field [0001] The present invention relates to a pharmaceutical composition and its application. Specifically, the present invention relates to a hydrogel composition, a method for preparing the hydrogel composition, an application of the hydrogel composition for relieving symptoms caused by hypertrophic scars, and a method for relieving such symptoms. Methods and medical devices. Background technique [0002] Burn-related injuries are a major health problem worldwide, with an estimated 265,000 related deaths per year reported by the World Health Organization (WHO Fact Sheet 2014). In particular, most of the deaths occurred in low- and middle-income countries. In China, there are approximately 15,000,000 to 20,000,000 burn cases per year (incidence ranges from 0.5% to 1.5%, depending on the standard), and an estimated 2,000,000 to 3,000,000 burn patients require hospitalization. [0003] When normal skin tissue is damaged by burns, damage, disease or infection, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/045A61K47/36A61P17/02A61P17/04A61P29/00
CPCA61K31/045A61K31/736A61K31/738A61K9/06A61K47/36A61K9/5161A61K9/0014A61P17/02A61P17/04A61P29/00A61P43/00A61K2300/00
Inventor 吴军罗高兴刘耀南霍文逊黄骏豪富利乐李德晃
Owner CHONGQING MJ MEDICAL DEVICES
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