Aqueous Phase Synthesis of au@cu2-xe Super Nanoparticles

A nanoparticle, super technology, applied in nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve problems such as unfavorable application, harsh replacement conditions, and Cd toxicity

Active Publication Date: 2019-06-25
ANHUI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, Au@Cu for the above core-shell structure 2-x There are generally two methods for the preparation of S, one is the oil phase synthesis method, which makes it have poor biocompatibility; the other is to obtain Au@CdS through aqueous phase synthesis, and then obtain Au@CuS through cation exchange. , but due to the limitation of thermodynamic equilibrium, Cd ions cannot be completely replaced, and the replacement conditions are harsh, and Cd is toxic, which is not conducive to the application in living organisms

Method used

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  • Aqueous Phase Synthesis of au@cu2-xe Super Nanoparticles
  • Aqueous Phase Synthesis of au@cu2-xe Super Nanoparticles
  • Aqueous Phase Synthesis of au@cu2-xe Super Nanoparticles

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Will 2.5×10 -5 mol of chloroauric acid and 99mL of water are heated and boiled under the condition of magnetic stirring to obtain an aqueous solution of chloroauric acid, and 8.75×10 -5 After the first mol of trisodium citrate, continue heating for 30 min to obtain a mixture M1. After the mixture M1 is cooled to 25° C., an aqueous solution of polyvinylpyrrolidone (prepared by dispersing 0.2 g of polyvinylpyrrolidone into 10 mL of water) is added thereto to prepare Au nanoparticle solution was obtained; the Au nanoparticle solution, 2 × 10 -5 mol second trisodium citrate and 9 x 10 -6 mol of copper sulfate pentahydrate was mixed to prepare the mixture M2, the mixture M2 was adjusted to pH 9.3 with 0.5mol / L sodium hydroxide, nitrogen gas was introduced for 20min, and then 3×10 -6 mol of thioacetamide and 3 x 10 -5 mol of hydroxylamine hydrochloride, heated in an oil bath at 70°C, refluxed for 12 hours, and then centrifuged for 30 minutes to obtain Au@Cu 2-x S Super Na...

Embodiment 2

[0046] Prepare according to the method of Example 1, the difference is that the amount of thioacetamide is 6 × 10 -6 mol, the consumption of the hydroxylamine hydrochloride is 6×10 -5 mol, and finally get Au@Cu 2-x S Super Nanoparticles A2.

Embodiment 3

[0048] Prepare according to the method of Example 1, the difference is that the amount of thioacetamide is 1.2 × 10 - 5 mol, the consumption of the hydroxylamine hydrochloride is 1.2×10 -4 mol, and finally get Au@Cu 2-x S super nanoparticles A3.

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Abstract

The invention discloses an aqueous phase synthesis of Au@Cu 2‑x The method of E super-nanoparticles, said method comprises: the chloroauric acid aqueous solution and the first trisodium citrate are mixed and then heated to obtain a mixture M1, and an aqueous solution of polyvinylpyrrolidone is added to the mixture M1 to obtain an Au nanoparticle solution ; The Au nanoparticle solution prepared in step (1), the second trisodium citrate and the copper salt are mixed to prepare the mixture M2, after the mixture M2 is adjusted to a pH of 9.2-9.4, thioxate is added to the mixture M2 Au@Cu prepared by heating after acetamide and hydroxylamine hydrochloride 2‑x S super nanoparticles; the method is simple to operate, requires low synthesis conditions and is universal.

Description

technical field [0001] The present invention relates to the field of synthesis of super nanoparticles, in particular to an aqueous phase synthesis of Au@Cu 2-x E Supernanoparticle Method. Background technique [0002] Au@Cu 2-x S super nanoparticles and Au@Cu 2-x Se supernanoparticles are widely used in living organisms, photoacoustic imaging, CT imaging, and photothermal therapy of living tumors because of their strong absorption in the near-infrared and high photothermal stability and Au's excellent X-ray attenuation ability. . Currently, Au@Cu for the above core-shell structure 2-x There are generally two methods for the preparation of S, one is the oil phase synthesis method, which makes it have poor biocompatibility; the other is to obtain Au@CdS through aqueous phase synthesis, and then obtain Au@CuS through cation exchange. , but due to the limitation of thermodynamic equilibrium, Cd ions cannot be completely replaced, and the replacement conditions are harsh. At...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/0553B22F1/07B22F1/054
Inventor 夏云生朱慧刘春秀朱霜霜吕杨凌云云汪宜张冰洁马明柔韦妹妹罗荣
Owner ANHUI NORMAL UNIV
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