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Application of forsythiaside A in preparation of hepatic fibrosis resisting pharmaceutic preparation

An anti-liver fibrosis and forsythoside technology is applied in the application field of forsythoside A in the preparation of anti-liver fibrosis pharmaceutical preparations, and can solve the problem of liver fibrosis treatment without better therapy, damage, and formation of gates. pulse hypertension and other problems, to achieve good medicinal prospects

Inactive Publication Date: 2017-11-03
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This can eventually result in the formation of extensive fibrous junctions in the liver tissue, leading to a state of portal hypertension, further impairing this function
At present, there is no good therapy for the treatment of liver fibrosis, and the method of removing the cause is generally used

Method used

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  • Application of forsythiaside A in preparation of hepatic fibrosis resisting pharmaceutic preparation
  • Application of forsythiaside A in preparation of hepatic fibrosis resisting pharmaceutic preparation
  • Application of forsythiaside A in preparation of hepatic fibrosis resisting pharmaceutic preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The preparation of embodiment 1 capsule

[0052] Forsythiaside A 2g, lactose 20g, hydroxymethyl starch sodium 0.1g, starch slurry amount, magnesium stearate 0.1g, mix, sieve and granulate, mix well after drying and put into capsules, each capsule contains forsythia Glycoside A 0.02g, take 1-2 capsules orally every day, twice a day. The preparation of embodiment 2 tablet

Embodiment 2

[0053] 5g forsythiaside A, 200g lactose, appropriate amount of starch slurry, 1g magnesium stearate, mixed, sieved, dried and pressed into tablets. Each tablet contains matrine dimer A or B 0.02g. Take 1-2 tablets orally twice a day.

Embodiment 3

[0054] The preparation of embodiment 3 injection

[0055] Forsythiaside A 2g, propylene glycol 50g, grind, add a small amount of water for injection to dilute, mix well, then add an appropriate amount of sodium chloride, dissolve and then add water for injection to 1000ml, adjust the pH value to 5.5-6.5, filter, potting , sterilized to get 1000 injections.

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Abstract

The invention discloses application of forsythiaside A in preparation of a hepatic fibrosis resisting pharmaceutic preparation. A new treatment means is provided for treatment of hepatic fibrosis of a chronic liver disease, obvious toxic or side effects does not exist under therapeutic dose, and the clinical pharmaceutic prospect is good.

Description

technical field [0001] The invention relates to a new application of forsythiaside A, in particular to the application of forsythiaside A in the preparation of anti-hepatic fibrosis pharmaceutical preparations. Background technique [0002] Forsythia is the dry fruit of Forsythia suspensa (Thunb.) Vahl, a plant of Oleaceae. It has the effects of clearing away heat and detoxification, and evacuating wind-heat. In traditional Chinese medicine, it is often used to treat carbuncle, erysipelas, wind-heat cold, warm heat, high fever and polydipsia. Forsythiaside A is one of the main active ingredients in Forsythia, which is considered to have neuroprotective effects on cognitive impairment and transient cerebral ischemia, and has a wide range of effects such as improving learning and memory impairment, relaxing blood vessels, preventing infection, and antipyretic. pharmacological effects. [0003] Liver fibrosis is the ultimate pathological process of chronic liver disease, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P1/16
CPCA61K31/7032
Inventor 余林中马嘉镁黄嘉维卢子滨谢佩周红玲杨华一
Owner SOUTHERN MEDICAL UNIVERSITY
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