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Application of rhizoma atractylodis macrocephalae in preparation of medicines for promoting proliferation of bone marrow mesenchymal stem cells, and medicines

A technology for the proliferation of bone marrow mesenchymal and stem cells, which can be used in drug combinations, bone diseases, pharmaceutical formulations, etc. Effect

Active Publication Date: 2017-11-07
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide the application and medicine of Atractylodes macrocephala in the preparation of drugs for promoting the proliferation of bone marrow mesenchymal stem cells, which aims to improve the existing problems of weak proliferative activity and slow expansion speed of bone marrow mesenchymal stem cells

Method used

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  • Application of rhizoma atractylodis macrocephalae in preparation of medicines for promoting proliferation of bone marrow mesenchymal stem cells, and medicines
  • Application of rhizoma atractylodis macrocephalae in preparation of medicines for promoting proliferation of bone marrow mesenchymal stem cells, and medicines
  • Application of rhizoma atractylodis macrocephalae in preparation of medicines for promoting proliferation of bone marrow mesenchymal stem cells, and medicines

Examples

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Embodiment 1

[0052] This embodiment provides a kind of medicine, and this medicine is made by following preparation method:

[0053]Take 40g of Atractylodes macrocephala and 800ml of distilled water (ratio of solid to liquid: 1:20), heat and extract the distilled water for 4 hours under reflux, filter, and evaporate the solution to a volume of about 80ml through a rotary evaporator, and add 3 times the volume of 95% ethanol while stirring to adjust the ethanol concentration It was 90%, and it was allowed to stand at 4°C for 12 hours to precipitate with alcohol, and then dried by suction filtration.

Embodiment 2

[0055] This embodiment provides a kind of medicine, and this medicine is made by following preparation method:

[0056] Take 30g of Atractylodes macrocephala, first soak in 450g of distilled water for 30min, then put it in a decoction container, decoct with low heat for 2 hours, filter, and decoct the filter residue with 10 times the amount of distilled water for 2 hours, combine the decoction and concentrate it into 300ml, which is equivalent to the original medicinal material The 0.1g / mL liquid medicine is cooled and filled into sterilized medicine bottles, and stored in a refrigerator at 4°C for later use.

Embodiment 3

[0058] This embodiment provides a kind of medicine, and this medicine is made by following preparation method:

[0059] Take 40g of Atractylodes macrocephala and 720ml of distilled water (ratio of solid to liquid: 1:18), heat and extract the distilled water for 4 hours under reflux, filter, and then evaporate the solution to a volume of about 80ml through a rotary evaporator, use n-butanol to extract the concentrated solution, and take the extracted part .

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Abstract

The invention relates to the field of medicines, in particular to application of rhizoma atractylodis macrocephalae in preparation of medicines for promoting proliferation of bone marrow mesenchymal stem cells, and the medicines. The invention provides the application of the rhizoma atractylodis macrocephalae in preparation of the medicines for promoting the proliferation of the bone marrow mesenchymal stem cells. The medicines for promoting the proliferation of the bone marrow mesenchymal stem cells are prepared from the raw material-rhizoma atractylodis macrocephalae. The rhizoma atractylodis macrocephalae, a rhizoma atractylodis macrocephalae decoction or a rhizoma atractylodis macrocephalae water-extracted alcohol-precipitated product can promote the proliferation of the bone marrow mesenchymal stem cells in a culturing process and improve the proliferation ability of the bone marrow mesenchymal stem cells, so that a new implementation method is provided for clinical demands. Furthermore, the medicines, prepared from the rhizoma atractylodis macrocephalae water-extracted alcohol-precipitated product and the bone marrow mesenchymal stem cells, have a repair effect for colonic mucosal injury.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application and medicine of Atractylodes macrocephala in the preparation of medicines for promoting the proliferation of bone marrow mesenchymal stem cells. Background technique [0002] Atractylodes macroephalae (rhizoma atractylodis macroephalae) is a plant of the Compositae family. Atractylodis macroephalae is sweet, bitter, warm and non-toxic. Restless fetal movement can treat phlegm dampness, spleen deficiency and diarrhea. The main functions of Atractylodes macrocephala are sedation, vasodilation, anticoagulant, anti-gastric ulcer, liver protection and choleresis, diuresis, strengthening, improving immunity, anti-oxidation, antibacterial, etc. Contents of the invention [0003] The purpose of the present invention is to provide the application and medicine of Atractylodes macrocephala in the preparation of drugs for promoting the proliferation of bone marrow mesenchymal stem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/284A61P19/00A61P11/00A61P1/16A61P25/00A61P1/00
CPCA61K36/284A61K2236/331A61K2236/55
Inventor 郑志娟王峻清宋小莉
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE