Collagen/bacterial cellulose composite membrane dressing and preparing method thereof

Abstract

The invention discloses a collagen / bacterial cellulose composite membrane dressing and a preparing method thereof. The preparing method includes the steps that a natural bacterial cellulose membrane is purified; vacuum freeze drying is directly conducted on the purified water-containing bacterial cellulose membrane without pre-freezing treatment to obtain the bacterial cellulose membrane of a macroporous structure; at the temperature equal to or lower than 20 DEG C, an acetic acid water solution is used for dissolving natural collagen to obtain a collagen solution; the bacterial cellulose membrane of the macroporous structure is soaked in the collagen solution, and collagen is guided into the bacterial cellulose membrane under the vacuumizing condition; the bacterial cellulose membrane into which collagen is guided is placed in a phosphate buffered solution with the pH value of 6.0-8.0 to be subjected to fibration, and the composite membrane with collagen fibration is obtained; vacuum freeze drying is directly conducted on the composite membrane with collagen fibration without pre-freezing treatment to obtain the collagen / bacterial cellulose composite membrane dressing. Collagen guiding-in amount is obviously increased, and biological stability and retaining stability of collagen in the membrane are obviously improved.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and more specifically relates to a collagen / bacterial cellulose composite film dressing and a preparation method thereof. Background technique [0002] Medical dressings are widely used in clinical surgical fields such as skin trauma and burn treatment. High-quality medical dressings require good biological safety, barrier properties, water absorption and water retention, and suitable mechanical properties. For higher-end medical dressing products, such as dressings for large area burns, in order to promote the self-healing of skin tissue and reduce the pain of patients during dressing replacement, dressings are often required to have the properties of promoting tissue healing and the dressing itself can be degraded. Therefore, more and more natural macromolecular materials with the above-mentioned biological effects are applied in the manufacture of medical dressings. Among them, ...

AI Technical Summary

Problems solved by technology

Due to the existing collagen / bacterial cellulose composite film dressing (material) manufacturing process, there are still many deficiencies, such as the introduction of toxic chemical reagents in the manufacturing process, resulting in reduced biological safety of the dressing, low collagen import or unstable combination of imported collagen It is difficult to meet the requirements of biological efficacy, extreme conditions in the manufacturing process lead to collagen denaturation and loss of its biological activity, and the manufacturing process destroys the natural network structure of the bacterial cellulose membrane, resulting in a decrease in membrane performance, etc.

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