Drug delivery membrane for periodontitis, and preparation method thereof

A periodontitis and drug delivery technology, applied in the field of periodontitis drug delivery film and its preparation, can solve the problems of limited treatment application, drug toxicity and side effects, etc., and achieve the effects of enhancing immune function, rapid absorption, and promoting periodontal attachment Effect

Inactive Publication Date: 2017-11-10
常州市协旺纺织品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention: the current medicines for the treatment of periodontitis are still mainly chemical medicines, especially antibacterial medicines. Due to the rapid development of bacterial drug resistance and the toxic and side effects of the medicine itself, its application in the treatment is limited. The problem of application, the invention provides a kind of periodontitis drug-administered film and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] Wash honeysuckle with deionized water for 2 times, air-dry naturally, then transfer to a pulverizer to pulverize, pass through a 80-mesh sieve to obtain honeysuckle powder, wash the root of Scutellaria baicalensis twice with deionized water, then air-dry naturally, then transfer to a pulverizer to pulverize , pass through 80 mesh sieves, get root powder of Scutellaria baicalensis, get 300g honeysuckle powder, 200g root powder of Scutellaria scutellariae, add 5L mass fraction and be in 60% ethanol solution, and assisted extraction with 240W microwave for 3min, transfer in the centrifuge again, with Centrifuge at 4000r / min for 15min to obtain the extract and precipitate, add the precipitate to 5L of 60% ethanol solution, extract with 240W microwave for 3min, then transfer to a centrifuge, centrifuge at 4000r / min for 15min, combine The extract is obtained by extracting the fire-removing traditional Chinese medicine. Concentrate the fire-removing Chinese medicine extract und...

example 2

[0024] Wash honeysuckle with deionized water for 3 times, air-dry naturally, then transfer to a pulverizer for pulverization, pass through a 80-mesh sieve to obtain honeysuckle powder, wash the root of Scutellaria baicalensis 3 times with deionized water, then air-dry naturally, then transfer to a pulverizer for pulverization , pass through 80 mesh sieves, get root powder of Scutellaria baicalensis, get 400g honeysuckle powder, 250g root powder of Scutellaria scutellariae, add 5L mass fraction and be in 60% ethanol solution, and assisted extraction with 240W microwave for 4min, then transfer in the centrifuge, with Centrifuge at 4500r / min for 18min to obtain the extract and precipitate, add the precipitate to 5L of 60% ethanol solution, and use 240W microwave to assist extraction for 4min, then transfer to a centrifuge, centrifuge at 4500r / min for 18min, combine The extract is to obtain the Chinese medicine fire-removing extract, and the Chinese medicine fire-removing extract i...

example 3

[0026]Wash honeysuckle with deionized water for 3 times, air-dry naturally, then transfer to a pulverizer for pulverization, pass through a 80-mesh sieve to obtain honeysuckle powder, wash the root of Scutellaria baicalensis 3 times with deionized water, then air-dry naturally, then transfer to a pulverizer for pulverization , through 80 mesh sieves, to get Scutellaria root powder, get 500g honeysuckle powder, 300g Scutellaria root powder, add 6L mass fraction and be 60% ethanol solution, and assisted extraction 5min with 240W microwave, transfer in the centrifuge again, with Centrifuge at 5000r / min for 20min to obtain the extract and precipitate, add the precipitate to 6L of ethanol solution with a mass fraction of 60%, and assisted extraction with 240W microwave for 5min, then transfer to a centrifuge, centrifuge at 5000r / min for 20min, combine The extract is to obtain the Chinese medicine fire-removing extract, and the Chinese medicine fire-removing extract is concentrated t...

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PUM

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Abstract

The present invention relates to a drug delivery membrane for periodontitis, and a preparation method thereof, and belongs to the technical field of drug delivery membranes. According to the present invention, traditional Chinese medicines and minocycline hydrochloride are combined; periodontitis is treated through effects of stomach heat clearing, blood cooling, detoxification, heat clearing, yin nourishing, kidney invigorating, bone marrow benefiting, qi supplementing, blood enriching, tooth strengthening and gingiva care; and the drug delivery membrane has effects of patient microcirculation improving, inflammation resistance, gingival bleeding symptom relieving, whole immune function enhancing, periodontal soft tissue repair restoring, defensive ability restoring, inflammation eliminating, tissue regeneration promoting, tooth strengthening and periodontium fixation, can act on Gram-positive bacteria and Gram-negative bacteria, further has advantages of high efficiency, broad broad spectrum and rapid absorption, can inactivate collagenase in gingival crevicular fluid, can achieve the high concentration at the local for a long time so as to provide the antibacterial effect, and can cause the decalcification of tooth root surface, wherein the exposed collagen can stimulate the cells in connective tissue to migrate on the root surface, such that the adhesion and the growth of the cells can be promoted, and the movement of the epithelial cells to the root direction along the root surface can be inhibited to promote the peridontal adhesion so as to effectively solve the periodontitis.

Description

technical field [0001] The invention relates to a drug-administered membrane for periodontitis and a preparation method thereof, belonging to the technical field of drug-administered membranes. Background technique [0002] Periodontitis is an infectious disease of periodontal tissue caused by dental plaque biofilm, which can lead to the destruction of tooth supporting tissues (gingiva, periodontal ligament, alveolar bone and cementum), and eventually form periodontal pockets, induce Inflammation, progressive attachment loss, and alveolar bone resorption. Dental plaque colonized at the gingiva-dental junction can cause chronic inflammation of the gingiva over time, and gingivitis lesions can develop deep into the periodontal area, resulting in the reduction and destruction of collagen fibers in the gingival connective tissue, and the combined epithelium hyperplasia toward the root of the tooth, followed by tooth decay. Peripheral pockets, alveolar bone resorption, alveolar ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K36/539A61K47/38A61P1/02A61P31/04A61P29/00A61P9/14A61P37/04A61K31/65
CPCA61K9/006A61K9/7007A61K31/65A61K36/355A61K36/539A61K47/38A61K2300/00
Inventor邵俊英王之霖
Owner常州市协旺纺织品有限公司