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Preparation method for cyclohexanecarboxylic acid

A technology of cyclohexyl formic acid and benzoic acid, applied in the direction of ozone oxidation to prepare carboxylic acid, organic chemistry, etc., can solve the problems of unfavorable industrial production, high price of palladium, high cost, etc., and achieve the effect of improving catalytic activity, cheap price and ensuring efficiency

Active Publication Date: 2017-11-21
SHANGYU SUNFIT CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of catalyst has high catalytic activity, but because the price of palladium is relatively expensive, the cost is high, which is not conducive to industrial production

Method used

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  • Preparation method for cyclohexanecarboxylic acid
  • Preparation method for cyclohexanecarboxylic acid
  • Preparation method for cyclohexanecarboxylic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) In the 500mL reactor, add 5g nickel-aluminum-iron-copper alloy (containing 50% nickel, 15% iron, copper, 5%, the rest is aluminum) and 50ml distilled water, under constant stirring, Solid sodium hydroxide was added. Add the speed and quantity of sodium hydroxide to keep the reaction solution violently boiling without overflowing the container. When adding sodium hydroxide reaches about 8g, continue to add and when no longer reacting, stop adding alkali. Stand still for 10 minutes, then keep warm on a water bath at 70°C for 30 minutes, and the spongy nickel sinks to the bottom of the bottle. The supernatant is poured off, and the catalyst product is obtained by washing with decantation for 2 to 3 times under shaking.

[0022] (2) Add 29.4g (0.24mol) of benzoic acid and 300mL of ethanol to a 1L stainless steel autoclave. After stirring evenly, add 0.15g of the catalyst product obtained in step (1). After nitrogen replacement for 3 times, control the hydrogen pressur...

Embodiment 2

[0024] (1) In the 500mL reactor, add 5g nickel-aluminum-iron-copper alloy (containing 50% nickel, 20% iron, copper, 10%, the rest is aluminum) and 50ml distilled water, under constant stirring, Solid sodium hydroxide was added. Add the speed and quantity of sodium hydroxide to keep the reaction solution violently boiling without overflowing the container. When adding sodium hydroxide reaches about 8g, continue to add and when no longer reacting, stop adding alkali. Stand still for 10 minutes, then keep warm on a water bath at 70°C for 30 minutes, and the spongy nickel sinks to the bottom of the bottle. The supernatant is poured off, and the catalyst product is obtained by washing with decantation for 2 to 3 times under shaking.

[0025] (2) Add 29.4g (0.24mol) of benzoic acid and 300mL of ethanol to a 1L stainless steel autoclave. After stirring evenly, add 0.15g of the catalyst product obtained in step (1). After nitrogen replacement for 3 times, control the hydrogen pressu...

Embodiment 3

[0027] (1) In the 500mL reactor, add 5g nickel-aluminum-iron-copper alloy (containing 50% nickel, 15% iron, copper, 5%, the rest is aluminum) and 50ml distilled water, under constant stirring, Solid sodium hydroxide was added. Add the speed and quantity of sodium hydroxide to keep the reaction solution violently boiling without overflowing the container. When adding sodium hydroxide reaches about 8g, continue to add and when no longer reacting, stop adding alkali. Stand still for 10 minutes, then keep warm on a water bath at 70°C for 30 minutes, and the spongy nickel sinks to the bottom of the bottle. The supernatant is poured off, and the catalyst product is obtained by washing with decantation for 2 to 3 times under shaking.

[0028] (2) Add 29.4g (0.24mol) of benzoic acid and 300mL of ethanol to a 1L stainless steel autoclave. After stirring evenly, add 0.15g of the catalyst product obtained in step (1). After nitrogen replacement for 3 times, control the hydrogen pressur...

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Abstract

The invention discloses a preparation method for cyclohexanecarboxylic acid. The preparation method comprises the following steps: performing a reduction reaction on benzoic acid under the action of a hydrogenation catalyst and hydrogen; after the reaction is ended, treating to obtain the cyclohexanecarboxylic acid, wherein the hydrogenation catalyst contains the following components in percentage by weight: 40 to 50 percent of Ni, 10 to 15 percent of Fe, 5 to 8 percent of Cu and the balance of Al. The catalyst used in the preparation method is low in cost; meanwhile, the yield of the reaction is high, so that the preparation method has better industrial application significance.

Description

technical field [0001] The invention belongs to the field of preparation of chemical intermediates, in particular to a preparation method of cyclohexyl formic acid. Background technique [0002] Cyclohexylcarboxylic acid, whose structure is shown in formula (I), is a kind of important organic synthesis intermediate and chemical raw material, can be used for synthesizing medicines such as antipregnancy 392 and praziquantel, can also be used as a kind of good photocuring agent. In addition, its derivatives such as methyl cyclohexanecarboxylate and trans-4-isopropyl cyclohexanecarboxylic acid are also important intermediates in the synthesis of many chemical products and medicines. [0003] [0004] At present, cyclohexyl formic acid is generally prepared by hydrogenation reduction of benzoic acid, and the catalyst used is generally a supported palladium catalyst, such as a palladium catalyst supported by activated carbon or a palladium catalyst supported by alumina. People ...

Claims

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Application Information

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IPC IPC(8): C07C61/08C07C51/36
CPCC07C51/36C07C61/08
Inventor 李文黄生建陈炯明梁旭华常鹏胡金铬李东平
Owner SHANGYU SUNFIT CHEM
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