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Procyanidine-containing prebiotics and application thereof to obesity and metabolic syndrome medicines

A technology for metabolic syndrome and proanthocyanidins, which is applied to prebiotics containing proanthocyanidins and in the field of obesity and metabolic syndrome drugs, can solve problems such as lowering blood lipids, reduce visceral fat accumulation, improve insulin sensitivity, and improve host obesity and obesity. Effects of metabolic syndrome

Inactive Publication Date: 2017-11-24
SHANGHAI INST FOR ENDOCRINE & METABOLIC DISEASES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it did not clarify the mechanism of how proanthocyanidins regulate lipid metabolism, but only by observing the effect of proanthocyanidin prophylactic administration on the lipid metabolism disorder model in rats, it was concluded that it can reduce blood lipids, liver lipids and protect the liver conclusion

Method used

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  • Procyanidine-containing prebiotics and application thereof to obesity and metabolic syndrome medicines
  • Procyanidine-containing prebiotics and application thereof to obesity and metabolic syndrome medicines
  • Procyanidine-containing prebiotics and application thereof to obesity and metabolic syndrome medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Experiment

[0028] 1. Experimental animal operation

[0029] 1.1 Animal handling

[0030] Eight-week-old, SPF-grade male C57BL / 6J mice were purchased from Shanghai Slack Experimental Animal Co., Ltd. The animals used in this study have been approved by the Ethics Committee of the Animal Center of Shanghai Jiaotong University School of Medicine (B-2015-018).

[0031] Mice feeding environment: 3 mice / cage were kept in the isolation bag of the Experimental Animal Center of Shanghai Jiao Tong University School of Medicine, the circadian rhythm was 12h-12h, the lights were turned on at 8:00AM, and the lights were turned off at 20:00PM; adequate food and water were given. Free access to food.

[0032] Mouse diet: standard commercial mouse common feed, containing 4.5% fat; 4% cellulose; 21% protein, 1.404kal / g. High fat feed (Research Diet), containing 60% fat, 20% carbohydrate, 20% protein, 5.243kcal / g.

[0033] After the mice were bred for 4 weeks to adapt to the en...

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Abstract

The invention discloses procyanidine-containing prebiotics and application thereof to obesity and metabolic syndrome medicines. The prebiotics take procyanidine as the main active ingredient. Procyanidine can improve the obesity and metabolic syndromes through wholly or partially depending on intestinal flora regulation. The relationship between GSPE and intestinal flora, inflammation and metabolism is creatively established for the first time to testify that the metabolism improvement function of GSPE wholly or partially depends on the intestinal flora. GSPE can serve as a brand-new prebiotics to be used for improving the obesity and metabolic syndromes of hosts, particularly abdominal obesity and 2-type diabetes.

Description

technical field [0001] The invention relates to a prebiotic composition, in particular to a proanthocyanidin-containing prebiotic and its use in medicines for obesity and metabolic syndrome. Background technique [0002] Obesity and overweight have gradually become public health problems worldwide. Abnormal accumulation of visceral fat is a sign of obesity. Visceral fat can secrete and release a variety of pro-inflammatory mediators, leading to chronic, low-level inflammation in obese people; inflammation further damages glucose metabolism and lipid metabolism, and eventually insulin resistance and metabolic syndrome appear. The visceral fat of obese patients usually shows obvious accumulation of macrophages, and the aggregated macrophages can secrete a variety of pro-inflammatory factors, such as TNF-α and IL-6, which are clearly related to abnormal metabolism. The interaction between adipocytes and macrophages can amplify inflammatory signals step by step, and eventually ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P3/00A61P3/04A61P3/10
CPCA61K31/352
Inventor 宁光王卫庆洪洁刘瑞欣王计秋刘文
Owner SHANGHAI INST FOR ENDOCRINE & METABOLIC DISEASES
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