A preparation method of anti-adhesion medical antibacterial gauze for treating burns

An anti-adhesion and gauze technology, which is applied in the field of medical material processing, can solve problems such as difficult promotion, secondary wound damage, and difficult preparation, so as to reduce the probability of wound infection, prevent drug burst release, and improve antibacterial ability.

Active Publication Date: 2020-07-31
ZHENDE MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Gauze commonly used in clinic has problems such as extremely poor antibacterial ability, easy infection, poor hygroscopicity, and easy stuffiness, and there is a problem that new granulation tissue is easy to grow into the mesh of the gauze. It is suitable for ordinary patients with small or not serious wounds, but For burn patients, due to the particularity of the large wound surface and serious ulceration, ordinary medical gauze is difficult to isolate and protect the wound, and it will also seriously affect the healing of the burn wound. come greater pain
[0003] In addition, most of the special burn gauzes mentioned in many papers and literatures have many processing steps, high cost, and difficult preparation, so it is difficult to popularize and realize; while some of the gauzes with simple steps have no obvious effect on burn wounds and slow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method for anti-adhesion medical antibacterial gauze for treating burns, comprising the following steps:

[0023] Preparation of antibacterial medicinal liquid: prepare Daqingye and Houttuynia cordata and decoct them with water four times the weight of Chinese medicinal materials for 2 hours, and then filter the decocted medicinal liquid to obtain a residue-free medicinal liquid for use;

[0024] Preparation of antibacterial extract: place the medicinal solution in a low temperature and reduced pressure environment and concentrate it to 1 / 4~1 / 5 of the original volume;

[0025] Gauze activation treatment: use 4~6 mol / L sodium hydroxide solution to soak for 5~10 mi, fully activate and then immerse in toluene solution containing 5% bromoisobutyryl bromide, so that it has the activity of initiating ATRP polymerization;

[0026] Preparation of mixed soaking solution: mix the antibacterial extract, sodium alginate, citric acid, and ultrapure water according to t...

Embodiment 2

[0031] A kind of preparation method of the anti-adhesion medical antibacterial gauze of present embodiment for the treatment of burns, comprises the following steps:

[0032] Preparation of antibacterial medicinal liquid: prepare Daqingye and Houttuynia cordata and decoct them with water four times the weight of Chinese medicinal materials for 2 hours, and then filter the decocted medicinal liquid to obtain a residue-free medicinal liquid for use;

[0033] Preparation of antibacterial extract: place the medicinal solution in a low temperature and reduced pressure environment and concentrate it to 1 / 4~1 / 5 of the original volume;

[0034] Gauze activation treatment: use 4~6 mol / L sodium hydroxide solution to soak for 5~10 mi, fully activate and then immerse in toluene solution containing 5% bromoisobutyryl bromide, so that it has the activity of initiating ATRP polymerization;

[0035] Preparation of mixed soaking solution: mix the antibacterial extract, sodium alginate, citric ...

Embodiment 3

[0040] A kind of preparation method of the anti-adhesion medical antibacterial gauze of present embodiment for the treatment of burns, comprises the following steps:

[0041] Preparation of antibacterial medicinal liquid: prepare Daqingye and Houttuynia cordata and decoct them with water four times the weight of Chinese medicinal materials for 2 hours, and then filter the decocted medicinal liquid to obtain a residue-free medicinal liquid for use;

[0042] Preparation of antibacterial extract: place the medicinal solution in a low temperature and reduced pressure environment and concentrate it to 1 / 4~1 / 5 of the original volume;

[0043] Gauze activation treatment: use 4~6 mol / L sodium hydroxide solution to soak for 5~10 mi, fully activate and then immerse in toluene solution containing 5% bromoisobutyryl bromide, so that it has the activity of initiating ATRP polymerization;

[0044] Preparation of mixed soaking solution: mix antibacterial extract, sodium alginate, citric acid...

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Abstract

The invention provides a preparation method of an anti-adhesion medical antibacterial gauze for treating burns, and belongs to the field of medical dressing processing. The preparation method comprises the following steps of antibacterial extracting solution preparation, gauze activation and modification treatment, mixed soak solution preparation and gel layer infusion. According to the preparation method, natural antibacterial matters in the traditional Chinese medicines are extracted through a boiling mode and are then filtered and concentrated to obtain an antibacterial medical solution, then the antibacterial medical solution, citric acid, glycerol and a sodium alginate solution are mixed, then an ordinary medical gauze with polyacrylic acid surface modification is soaked in mixed liquid, and the gauze soaked with the mixed liquid is taken out after being fully soaked and is treated by freeze drying to obtain a novel anti-adhesion high moisture-absorbent medical antibacterial gauze for treating the burns. The preparation method is simple and is liable in industrialization.

Description

technical field [0001] The invention relates to the field of medical material processing, in particular to a preparation method of anti-adhesion medical antibacterial gauze for treating burns. Background technique [0002] Gauze commonly used in clinic has problems such as extremely poor antibacterial ability, easy infection, poor hygroscopicity, and easy stuffiness, and there is a problem that new granulation tissue is easy to grow into the mesh of the gauze. It is suitable for ordinary patients with small or not serious wounds, but For burn patients, due to the particularity of the large wound surface and serious ulceration, ordinary medical gauze is difficult to isolate and protect the wound, and it will also seriously affect the healing of the burn wound. to greater pain. [0003] In addition, most of the special burn gauzes mentioned in many papers and literatures have many processing steps, high cost, and difficult preparation, so it is difficult to popularize and rea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/40A61L15/42A61L15/44A61L15/46A61L15/20A61L15/28A61K36/78A61K36/855A61P31/04A61P17/02
CPCA61K36/195A61K36/315A61K36/704A61K36/78A61K36/855A61L15/20A61L15/28A61L15/40A61L15/425A61L15/44A61L15/46A61L2300/30A61L2300/404A61L2300/41A61L2300/45A61L2300/604A61K2300/00C08L5/04
Inventor 鲁建国胡修元
Owner ZHENDE MEDICAL CO LTD
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