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Application of 1,6-hexanediol or derivatives thereof in preparation of hematologic tumor resistant drugs

A technology of tumor drugs and derivatives, which is applied in the direction of anti-tumor drugs, drug combinations, active ingredients of hydroxyl compounds, etc., to achieve the effect of inhibiting the liquid phase separation process, good application prospects, and inhibiting occurrence

Active Publication Date: 2017-12-01
海安百优基质生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether the malignant transformation of tumor cells is achieved through excessive or abnormal liquid phase separation, and whether the development of new anti-tumor drugs can be based on inhibiting the liquid phase separation process as a starting point, but there is no report in this regard in the prior art

Method used

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  • Application of 1,6-hexanediol or derivatives thereof in preparation of hematologic tumor resistant drugs
  • Application of 1,6-hexanediol or derivatives thereof in preparation of hematologic tumor resistant drugs

Examples

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Embodiment 1

[0021] 1. Experimental materials

[0022] 1,6-Hexanediol, supplier Sigma;

[0023] RPMI medium, English name RPMI Medium Modified, supplier HyClone;

[0024] PBS(1×), supplier HyClone;

[0025] Penicillin-Streptomycin Solution, English name Penicillin-Streptomycin Solution, supplier HyClone;

[0026] Fetal bovine serum, supplier Hangzhou Sijiqing Biological Engineering Materials Co., Ltd.;

[0027] CCK-8, English name Cell Counting Kit-8, supplier Dojindo Laboratories;

[0028] PI, English name Propidium Iodide, supplier Sigma.

[0029] 2. Experimental method

[0030] 1. 1,6-Hexanediol solution and PI dyeing solution configuration

[0031] 1,6-Hexanediol powder is dissolved in sterile water, the storage concentration is 1g / mL, and it is stored at 4℃ and protected from light;

[0032] PI was dissolved in PBS at a storage concentration of 10 mg / mL, and stored at 4°C in the dark.

[0033] 2. Cell culture

[0034] Diffuse large B-cell lymphoma cells HBL-1, SUDHL-2, myeloma cells U266, and Hodgkin’s...

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Abstract

The invention discloses application of 1,6-hexanediol or derivatives thereof in preparation of hematologic tumor resistant drugs. The 1,6-hexanediol or derivatives thereof are capable of damaging weak interaction of proteins, inhibiting the liquid phase separation process and effectively inhibiting occurrence and development of tumors. The 1,6-hexanediol is capable of relatively specifically inhibiting cell proliferation of diffused large B cell lymphoma, myeloma and other hematologic tumors, and has excellent application prospects in preparation of anti-tumor drugs for preventing and treating leukemia, lymphoma, multiple myeloma and the like.

Description

Technical field [0001] The present invention relates to the technical field of anti-tumor drugs, in particular to the application of 1,6-hexanediol or its derivatives in the preparation of anti-hematological tumor drugs. Background technique [0002] 1,6-hexanediol, its English name is 1,6-hexanediol, and its structural formula is: As an important fine chemical material, 1,6-hexanediol has a wide range of applications in polyurethane, polyester, coil coatings, light curing agents and other fields. In addition, because of its certain permeability, 1,6-hexanediol can also be used in cosmetic active ingredients and topical pharmaceutical compositions for skin diseases, but there is no report on its application in anti-tumor drugs. [0003] Leukemia, lymphoma and multiple myeloma are the main forms of hematological tumors. Acute leukemia occupies the eighth place among common malignant tumors, and lymphoma is also in the top ten, and the incidence is increasing year by year. The over...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A61P35/00A61P35/02
Inventor 范义辉毛仁芳吴圆圆杨日云汪晓莺陈霞王守艳
Owner 海安百优基质生物工程有限公司