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Application of anoectochilus roxburghii polysaccharide extract

A technology of polysaccharide extraction and clematis, applied in the field of medicine, to achieve anti-fatigue effect, obvious effect, and the effect of improving antioxidant capacity

Active Publication Date: 2017-12-01
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the anti-fatigue activity of polysaccharides in Clematis clematis

Method used

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  • Application of anoectochilus roxburghii polysaccharide extract
  • Application of anoectochilus roxburghii polysaccharide extract
  • Application of anoectochilus roxburghii polysaccharide extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] (1) Preparation of polysaccharide extract from Clematis clematis

[0015] Take clematis powder, heat and reflux extraction with 12 times the weight of 85% ethanol for 3 times, each time for 1.5 hours, extract the dregs of clematis with ethanol, use water as solvent, heat and extract for 3 times, each time for 1.5 hours , combine the extracts, concentrate the extracts, the volume-to-mass ratio of the concentrated solution to the original medicinal material is 2:1, add 95% ethanol until the alcohol content is 80% for precipitation, let stand for 12h, collect the precipitate, and pass the precipitate through 5 After washing with ethanol once, the precipitate was dried to obtain the crude polysaccharide extract of Auranthus clematis. Dissolve the crude polysaccharide extract of Clematis clematis in water, dialyze the supernatant with a dialysis bag with a relative molecular weight cut-off of 3500 or more for 48 hours, then pass the dialysate through a cation exchange resin,...

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Abstract

The invention relates to the field of medicines, in particular to application of an anoectochilus roxburghii polysaccharide extract. The anoectochilus roxburghii polysaccharide extract is used for preparing an anti-fatigue medicine, the anoectochilus roxburghii polysaccharide extract has obvious anti-fatigue effect and can obviously prolong weight-loading swimming time of a mouse, lower serum lactate dehydrogenase level after swimming, lower serum urea nitrogen content, improve the oxidation resistance of the mouse in a stress state and increase content of hepatic glycogen and muscle glycogen.

Description

technical field [0001] The invention relates to the application of a clematis polysaccharide extract, in particular to the application of the clematis polysaccharide extract in preparing anti-fatigue drugs, and belongs to the field of medicine. Background technique [0002] Fatigue is one of the ubiquitous physiological phenomena. With the acceleration of the social rhythm, long-term work tension, high competition pressure and emotional instability can easily lead to fatigue. Although fatigue is a common physiological state of the body, the decline in exercise capacity, work efficiency, and changes in central and peripheral nerve sensitivity caused by fatigue cannot be ignored. Therefore, the prevention and recovery of fatigue has always been the focus of current research. [0003] Currently on the market, chemical drugs for anti-fatigue, such as amphetamines, modafinil, and caffeine, have certain effects in delaying fatigue and eliminating fatigue, but long-term use has ce...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P39/00C08B37/00
CPCA61K31/715A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55C08B37/0003
Inventor 吴岩斌叶齐郑承剑吴建国吴锦忠易骏
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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