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Preparation method of N-lauroyl-L-lysine

A technology of lauroyl lysine and lysine, which is applied in the field of preparation of N-lauroyl-L-lysine, can solve the problems of many side reactions, low yield, and inability to achieve high yield and high yield. The effect of purity

Inactive Publication Date: 2017-12-01
SHANDONG KEXIN BIOCHEM
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

The disadvantage of the direct amidation of lysine is that the mixture of several compounds is obtained, and there are many side reactions, the post-treatment is very troublesome, the yield is very low, less than 30%, and it is impossible or difficult to obtain high-quality lauroyl lysine

Method used

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  • Preparation method of N-lauroyl-L-lysine
  • Preparation method of N-lauroyl-L-lysine
  • Preparation method of N-lauroyl-L-lysine

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Embodiment Construction

[0048] In order to facilitate understanding of the present invention, the present invention enumerates the following examples. Those skilled in the art should understand that the examples are only used to help understand the present invention, and should not be regarded as specific limitations on the present invention.

[0049] equipment used

[0050] The equipment used in the following examples is shown in Table 1 below.

[0051] Table 1

[0052]

[0053]

[0054] The materials used are as follows:

[0055] Lauric acid: scientific name dodecanoic acid, molecular formula: CH 3 (CH 2 ) 10COOH, molecular weight: 200. It has the smell of laurel oil, white needle-like crystals. The relative density is 0.8679 (50°C). The melting point is 44°C. The boiling point is 225°C (13.3 kPa, 100 mm Hg). Insoluble in water, soluble in ethanol, ether and benzene. Used in the production of alkyd resins, wetting agents, detergents, insecticides, etc. Separated from fatty acids i...

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Abstract

A preparation method of N-lauroyl-L-lysine comprises the following steps: (1) preparation of lysine laurate: mixing methanol, lauric acid and a lysine concentrated solution, rising the temperature, carrying out reflux reaction, cooling, filtering, and drying, thus obtaining the lysine laurate; (2) preparation of a lauroyl lysine coarse product: mixing the lysine laurate obtained in the step (1) with trimethylbenzene, rising the temperature, carrying out the reflux reaction, cooling after completing the reaction, adding in absolute methanol, continuously cooling after stirring, then filtering, and drying, thus obtaining the lauroyl lysine coarse product; (3) purification of the lauroyl lysine coarse product: carrying out acetic acid recrystallization, activated carbon decoloration and alcohol leaching on the lauroyl lysine coarse product obtained in the step (2), filtering and drying, thus obtaining an N-lauroyl-L-lysine fine product. According to the preparation method disclosed by the invention, higher yield is obtained, and the prepared product is higher in purity.

Description

technical field [0001] The invention belongs to the field of chemical product preparation, and in particular relates to a preparation method of N-lauroyl-L-lysine. Background technique [0002] Lauroyl lysine (N-Lauroyl-L-lysine, referred to as: LL, CAS: 52315-75-0) is a chemical substance with the molecular formula C 18 h 36 N 2 o 3 , the full name is N-lauroyl-L-lysine. Lauroyl lysine is synthesized from lauric acid and L-lysine and separated and purified. The raw materials come from natural sources, have good biodegradability, and are very safe. [0003] LL has high lubricity, silky skin feel, low friction coefficient, antistatic and antioxidative properties, insoluble in water and most organic solvents, soluble in concentrated acid and alkali, but it is easy to cause decomposition for a long time. The lamellar crystal structure of LL makes it feel smooth, delicate and soft like silk. It has been used in the surface treatment of high-end cosmetic powders, such as fo...

Claims

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Application Information

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IPC IPC(8): C07C231/10C07C231/24C07C233/47C07C227/00C07C229/26C07C51/41C07C53/126
CPCC07C231/10C07C51/412C07C227/00C07C231/24C07C233/47C07C229/26C07C53/126
Inventor 王广友刘军于乐祥程园杰石隆平
Owner SHANDONG KEXIN BIOCHEM
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