A cold-water fish probiotic Lactococcus lactis strain and its application

A technology of Lactococcus lactis and cold-water fish, applied in the field of microbiology, can solve the problem of low antibody titer
CN107418905BInactive Publication Date: 2021-02-19HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Publication Date
2021-02-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a cold-water fish probiotic Lactococcus lactis strain and its application. The present invention isolates and identifies a strain HZC32 that has antiviral properties, immune regulation and immune function enhancement properties to cold water fish from the intestinal mucosa of semi-wild rainbow trout juveniles in the Benxi mountainous area of ​​Liaoning Province. According to the observation of the morphological characteristics of the colony and the determination of the 16SrDNA base sequence and homology analysis, the strain identification result is: HZC32 belongs to Lactococcus lactis, and the preservation number is: CGMCC No.10705. The in vitro cell experiments proved that: Lactococcus lactis HZC32 strain co-cultured with virus-infected EPC cells has the property of resisting IHNV proliferation in EPC cells in vitro. Animal experiments have proved that: Lactococcus lactis HZC32 strain has the characteristics of immune regulation and immune function enhancement to cold-water fish, and the HZC32 strain fed alone also has the characteristics of anti-IHNV infection to cold-water fish. Thus it can be seen that the Lactococcus lactis HZC32 strain of the present invention has a certain application prospect in cold-water fish anti-virus, immune regulation and enhancement of cold-water fish immune function.
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Description

technical field

[0001] The invention relates to a probiotic bacterial strain and its use, in particular to a cold-water fish (rainbow trout) probiotic Lactococcus lactis HZC32 strain and its use. The invention belongs to the technical field of microbes. Background technique

[0002] Probiotics are the normal flora of human and animal intestinal tract, respiratory tract, reproductive tract and skin mucous membrane system. Many research results have found that lactic acid bacteria and intestinal mucosa together form a protective barrier to prevent the invasion of viruses and bacteria. Human beings are increasingly aware of In view of the powerful effect of probiotics on human and animal life and health, a large number of modern immunological research results have confirmed that probiotics (especially lactic acid bacteria) can regulate animal cellular immunity, humoral immunity and local immunity of intestinal mucosa, as well as immune system development and The indispensable d...

Claims

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