Multifunctional imaging cross-linked stable nanometer drug-loading micelles and preparation method thereof

A drug and carrier technology, which is applied in the field of preparation of acid-sensitive nanomicelles, can solve the problems of sudden release of drugs, inability to release drugs completely, and reduced cycle time, to overcome poor stability and targeting, and overcome instability and High toxicity and side effects, improved stability and dilution resistance
CN107434776AInactive Publication Date: 2017-12-05TIANJIN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN UNIV
Publication Date
2017-12-05
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The present invention discloses multifunctional imaging cross-linked stable nanometer drug-loading micelles and a preparation method thereof. The preparation method comprises: adding 200 mg of an amphiphilic drug carrier mPEG-S-Trityl-Cys-Dopa and a hydrophobic anti-cancer drug to an organic solvent, dissolving, and carrying out dialysis by using a dialysis bag to remove free Fe<3+>; carrying out centrifugation, and filtering the supernatant by using a 0.45 [mu]m microporous filtration membrane; and carrying out freeze drying on the filtrate, wherein the freeze-dried product is the multifunctional imaging cross-linked stable nanometer drug-loading micelles mPEG-S-Trityl-Cys-Dopa-Fe<3+> / hydrophobic anti-cancer drug. According to the present invention, the obtained nanometer micelles have the stability and the pH-sensitivity, and can be visible by MRI, can break through the single-function mode of the traditional drug delivery system, can integrate the MRI imaging function and the drug carrier function, and can achieve the synchronous diagnosis and treatment of cancers.
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Description

technical field

[0001] The invention relates to a functional nano-carrier with imaging and active molecule delivery functions, in particular to a method for preparing cross-linked and stable acid-sensitive nano-micelles visible in magnetic resonance imaging (MRI). Background technique

[0002] Cancer has been one of the major challenges to human health in this century. At present, many cancers are usually diagnosed in the middle and late stages clinically, but commonly used methods such as surgery, radiation therapy, and chemotherapy are not effective for advanced cancers. Therefore, early diagnosis and treatment of cancer are of great significance. MRI can detect slight changes between normal tissue and tumor tissue, and has become one of the important methods for early diagnosis of cancer. However, traditional MRI contrast agents have poor stability and poor targeting in blood, which limits their effective diagnosis of tumors. Chemotherapy is a commonly used method to tr...

Claims

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