Antibacterial peptide derivate and application thereof

A technology of antibacterial peptides and antibacterial drugs, which is applied in the field of hydrophobically modified antibacterial peptide DP7 derivatives, which can solve the problems of red blood cell toxicity, red blood cell destruction, red blood cell hemolysis, etc., and achieve good antibacterial activity, small molecular weight, freeze-dried and redissolved stability Effect
CN107446019AActive Publication Date: 2017-12-08SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2017-12-08

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Abstract

The invention belongs to the field of biological medicines, mainly relates to an antibacterial peptide derivate and the application thereof, in particular to a hydrophobic modified antibacterial peptide DP7 derivate and the application thereof. The hydrophobic modified antibacterial peptide is characterized in that a hydrophobic fragment is coupled to nitrogen terminal of the antibacterial peptide to realize the hydrophobic modification. The invention also provides a micelle which is prepared through the hydrophobic modified antibacterial peptide, and the application of the hydrophobic modified antibacterial peptide and the micelle in preparation of antibacterial medicines, preparation of a nucleic acid transporter and the preparation of an immunologic adjuvant. The antibacterial peptide is small in molecular weight and can be conveniently synthesized through an Fmoc solid-phase multi-peptide synthesis method; the hydrophobic fragment based chemical synthesizing coupling method is simple and easy to carry out.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and mainly relates to antimicrobial peptide derivatives and applications thereof, especially hydrophobically modified antimicrobial peptide DP7 derivatives and applications thereof. Background technique

[0002] Antimicrobial peptides, also known as host defense peptides (HDPs), generally consist of 12 to 100 amino acid residues, are a type of basic polypeptide, and most antimicrobial peptides are positively charged. Antimicrobial peptides have a broad-spectrum antibacterial effect, can effectively inhibit and kill fungi, viruses, parasites and other pathogens, and can selectively kill tumor cells, and are not easy to produce drug resistance. They constitute the first barrier for the host to defend against the invasion of pathogenic microorganisms. As an important component of the body's immune system, antimicrobial peptides have become potential drugs to replace antibiotics to prevent and control dise...

Claims

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