Metal organic frame material signal amplification electrochemical analysis paper chip sensor

A metal organic framework, electrochemical analysis technology, applied in the field of electrochemical analysis and detection, can solve the problems of no signal amplification, poor conductivity of paper chips, etc., and achieve the effects of reducing preparation cost, low detection limit, and simplifying preparation steps
CN107478701AInactive Publication Date: 2017-12-15UNIV OF JINAN
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV OF JINAN
Publication Date
2017-12-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a metal organic frame material signal amplification electrochemical analysis paper chip sensor and a method thereof for measuring microRNA. The method comprises the following steps: preparing a paper chip three-electrode system of which the surface is modified by nanogold particles; starting a chain hybridization reaction by adding microRNA while modifying the electrode surface with a functionalized metal organic frame material; dropwise adding a glucose-containing buffer solution in the detection area; through a catalytic reaction between the functionalized metal organic frame material and the glucose, realizing signal amplification and high-sensitivity detection of microRNA by a differential pulse voltammetry.
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Description

technical field

[0001] The invention relates to the technical field of electrochemical analysis and detection, more specifically to the construction of a paper chip laboratory technology platform for metal organic framework material signal amplification electrochemical analysis. Background technique

[0002] In recent years, the morbidity and mortality of cancer in my country have shown a gradual upward trend. The occurrence of tumors seriously affects people's quality of life and endangers people's life safety. Accurate, fast and simple detection of microRNA and its physiological activities in tumor cells Detection is of great significance for the diagnosis and treatment of diseases. Therefore, it is very important to find a rapid, quantitative and sensitive method for detecting microRNA in the early detection and treatment monitoring of cancer. The common way of clinical diagnosis is mainly through the detection of relatively expensive large-scale instrument analysis equip...

Claims

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