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Process for producing calcium D-pantothenate

A technology of calcium pantothenate and pantothenic acid, applied in organic chemistry, fermentation, etc., can solve problems such as lower crystallization yield, inability to remove monosaccharides or oligosaccharides, and high viscosity of D-calcium pantothenate

Inactive Publication Date: 2001-11-14
BASF AG
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Problems solved by technology

But this method has following shortcoming: (i) can not remove monosaccharide or oligosaccharide in liquid fermented liquid with ion-exchange resin treatment, the amount that contains sugar in crystallization mother liquor is equivalent to 10% of pantothenic acid, these remaining Monosaccharides or oligosaccharides that develop color during thermal concentration of ion-exchange resin-treated solutions or reduce crystallization yield during crystallization
Calcium D-pantothenate at this concentration has a high viscosity, which makes concentration of the solution very difficult

Method used

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  • Process for producing calcium D-pantothenate
  • Process for producing calcium D-pantothenate
  • Process for producing calcium D-pantothenate

Examples

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Embodiment 1

[0028] The Escherichia coli IFO 814 / pEV 31 strain was cultured in a 5-liter fermenter according to a conventional method. The medium contained glucose as a sugar source, and the direct fermentation medium (2.5 liters) containing D-pantothenic acid was obtained through fermentation. The liquid fermentation broth was filtered through a ceramic filter (manufactured by Toshiba Ceramics Co., Ltd.) having a mesh diameter of 0.1 µ at 40°C to remove insoluble matter such as bacterial cells to obtain a filtrate (1.67 liters). The filtrate contained D-pantothenic acid (38.5 mg / ml (64.3 g)), sugars (total amount determined by the phenol-sulfuric acid method: 10.3 mg / ml (about 27% based on D-pantothenic acid)). The filtrate was passed through an activated carbon column (inner diameter: 70 mm, height: 130 mm, packing volume: 500 ml) packed with activated carbon K1 for decolorization (manufactured by Takeda Chemical Industry Co., Ltd., sieve volume: 1.12 cc / g, average sieve diameter: 32A). ...

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Abstract

A process for producing calcium D-pantothenate, which comprises bringing a solution containing D-pantothenic acid directly produced by microbial fermentation into contact with activated carbon to adsorb the D-pantothenic acid to the activated carbon, eluting the D-pantothenic acid with a hydrophilic organic solvent, neutralizing the eluate with an alkali agent containing calcium to precipitate calcium D-pantothenate, and collecting the calcium D-pantothenate.

Description

[0001] scope of invention [0002] The present invention relates to a method for producing D-calcium pantothenate, which is obtained from the liquid fermented liquid in which microorganisms directly produce D-pantothenic acid. Calcium D-pantothenate has been widely used as a vitamin in medicine, food, feed and so on. background of the invention [0003] The conventional methods for producing calcium pantothenate can be roughly divided into chemical synthesis methods and direct fermentation methods. The chemical synthesis methods widely used in industrial production include synthesizing D, L-pantothenic acid lactone from the starting compound isobutyl aldehyde, performing optical resolution by chemical or enzymatic methods, and then obtaining D-pantothenic acid and β-alanine Calcium is condensed to give calcium D-pantothenate. As a method of direct fermentation, JP-A 6-261772 recently described a new method of directly producing D-pantothenic acid by microorganisms using suga...

Claims

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Application Information

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IPC IPC(8): C12P13/02
CPCC12P13/02
Inventor 西村淳三木啓司松本纯一渋谷浤作矢田英雄
Owner BASF AG
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