Nontransparent polymer resin and application thereof in serum separation gel

A technology for serum separation gel and polymer resin, which is applied in the field of serum separation gel and its preparation, can solve the problems of poor compatibility, easy phase separation, etc., and achieves the effects of moderate initiating activity, easy rate control, and reduced energy consumption.

Active Publication Date: 2017-12-26
湖北新德晟材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to change the deficiencies and shortcomings of existing products on the market, the purpose of the present invention is to solve the problems of poor compatibility and easy phase separation when a variety of macromolecular polymers are mixed to prepare separation gel in the prior art. ; At the same time, organic fluorosilicon is used to modify styrene and acrylate to make it more hydrophobic, and the cross-linking between molecules makes the performance of the polymer resin more stable, effectively solving the problem of ACD liquid pipe, PRP pipe (PRP pipe The composition of the additive is the same as that of the ACD solution), the problems of brine stability and acid-base stability during the storage of trisodium citrate tubes

Method used

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  • Nontransparent polymer resin and application thereof in serum separation gel
  • Nontransparent polymer resin and application thereof in serum separation gel
  • Nontransparent polymer resin and application thereof in serum separation gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0036] Example 2: Preparation of Opaque Polymer Resin

[0037]Put 275g of heptane into the reactor and heat up to 65-70°C; add 6.0g of AIBME to 62.5g of styrene, 137.5g of butyl acrylate, 20.0g of isooctyl methacrylate and 1.25g of n-dodecanethiol In the mixed solution formed, stir and mix evenly and AIBME is completely dissolved to form a mixed solution A, drop the mixed solution A into the reaction kettle, control the drop rate of the mixed solution A, and complete the dropwise addition in 2.35 hours. During the dropping process, control The temperature of the reaction solution is 65-70°C; after the dropwise addition, start to heat up, control the temperature of the reaction solution between 70-75°C, and keep it warm for 0.5h; In the mixed solution composed of heptyl ester and 17.5g vinyltrimethoxysilane, stir and mix until the AIBME is completely dissolved to form a mixed solution B, and then add the mixed solution B dropwise into the above reaction kettle, and keep the rea...

Embodiment 3

[0038] Example 3: Preparation of Opaque Polymer Resin

[0039] Put 275g of heptane into the reaction kettle, heat up to 65-70°C; add 6.0g of AIBME to 62.5g of styrene, 137.5g of butyl acrylate, 25.0g of isooctyl methacrylate and 1.25g of n-dodecanethiol In the mixed solution formed, stir and mix evenly and AIBME is completely dissolved to form a mixed solution A, drop the mixed solution A into the reaction kettle, control the drop rate of the mixed solution A, and complete the dropwise addition in 2.4 hours. During the dropping process, control The temperature of the reaction solution is 65-70°C; after the dropwise addition, start to heat up, control the temperature of the reaction solution between 70-75°C, and keep it warm for 0.5h; In the mixed solution composed of heptyl ester and 17.5g vinyltrimethoxysilane, stir and mix until the AIBME is completely dissolved to form a mixed solution B, and then add the mixed solution B dropwise into the above reaction kettle, and keep th...

Embodiment 4

[0040] Example 4: Preparation of Opaque Polymer Resin

[0041] Put 275g of heptane into the reaction kettle, heat up to 65-70°C; add 6.0g of AIBME to 62.5g of styrene, 137.5g of butyl acrylate, 25.0g of isooctyl methacrylate and 1.25g of n-dodecanethiol In the mixed solution formed, stir and mix evenly and AIBME is completely dissolved to form a mixed solution A, drop the mixed solution A into the reaction kettle, control the drop rate of the mixed solution A, and complete the dropwise addition in 2.6 hours. The temperature of the reaction liquid is 65-70°C; after the dropwise addition is completed, the temperature is raised, and the temperature of the reaction liquid is controlled between 70-75°C, and kept for 0.5h; ester and 15.0g of vinyltrimethoxysilane, stir and mix until the AIBME is completely dissolved to form a mixed solution B, and then add the mixed solution B dropwise into the above reaction kettle, and keep the reaction solution during the dropwise addition The t...

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Abstract

The invention belongs to the technical field of high-molecular polymer preparation and specifically relates to a nontransparent polymer resin and an application thereof in a serum separation gel. In a heptane solvent system, styrene, acrylics and a silane coupling agent are taken as monomers, dimethyl azo diisobutyrate is taken as an initiator for initiating the polymerization for the polymer resin and then the polymer resin is taken as a raw material for preparing an end product of the serum separation gel. The serum separation gel prepared according to the invention is less in dosage of inorganic white carbon black powder, excellent in thixotropic property, high in stability of storage and contact between the product and the blood and excellent in irradiation resistance.

Description

technical field [0001] The invention relates to the technical field of high molecular polymer preparation, in particular to a preparation method of an opaque polymer resin used for serum separation, a serum separation gel with a specific gravity between serum and plasma, good physiological inertness and a preparation method thereof. Background technique [0002] With the rapid development of laboratory medicine technology and the improvement of people's life rhythm, the inspection methods are becoming more and more automated, intelligent and precise. Simple, safe, and convenient disposable vacuum blood collection containers have been widely promoted and applied, so how to quickly separate high-quality, pollution-free serum that does not affect testing equipment is particularly important. People have invented a separation gel for separating serum and plasma. As a kind of blood collection container additive, it must have sufficient physiological inertia, good storage stability...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/18C08F212/08C08F220/24C08F230/08C08F4/04C08L33/08C08L71/02C08K3/36C08K5/12C08K5/5425B01D17/02
CPCB01D17/02C08F4/04C08F220/18C08F220/1804C08L43/04C08L71/02C08K3/36C08K5/12C08K5/5425C08F212/08C08F220/1808C08F220/24C08F230/08
Inventor 王中喜胡会弟王安琪
Owner 湖北新德晟材料科技有限公司
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