Hydrophobic sun-screening microcapsule and preparation method thereof

A microcapsule and hydrophobic technology, which is applied in pharmaceutical formulations, cosmetic formulations, cosmetic formulations, etc., can solve the problems of sunscreen microcapsules agglomeration, low stability, uneven distribution, etc., and achieves remarkable sunscreen effect and simple preparation process. , cheap effect

Inactive Publication Date: 2017-12-29
HUIZHOU RES INST OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the shortcomings of sunscreen microcapsules currently on the market, and provide a hydrophobic sunscre

Method used

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  • Hydrophobic sun-screening microcapsule and preparation method thereof
  • Hydrophobic sun-screening microcapsule and preparation method thereof
  • Hydrophobic sun-screening microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Weigh chitosan with a molecular weight of 5kda and a degree of deacetylation of 90% and place it in a beaker to prepare a 1% chitosan-water solution, add acetic acid to swell and adjust the solution to pH = 3, and set it aside. Weigh gum arabic and sodium caseinate with a mass ratio of 1:1, add water at room temperature and stir to dissolve, and control pH=6. Add 0.4g Tween T-80, stir evenly, then add 0.9g octyl methoxycinnamate, shear at high speed for 5min, control the speed = 10000rpm, and use it as the core material solution. Add the core material solution dropwise to the chitosan solution, control the mass ratio of chitosan: gum arabic: sodium caseinate to 2.5:1:1, control the speed = 400rpm, and control the temperature to 45°C after the dropwise addition is completed. 1h, then lowered to 4°C for 1h reaction, added glutaraldehyde for cross-linking reaction for 1h, and prepared liquid microcapsules. Add liquid microcapsules to 5% glutaraldehyde aqueous solution and...

Embodiment 2

[0040] Weigh chitosan with a molecular weight of 5kda and a degree of deacetylation of 90% and place it in a beaker to prepare a 1% chitosan-water solution, add acetic acid for swelling, adjust the pH of the solution to 3.5, and set aside. Weigh Arabic gum and sodium caseinate, the mass ratio is 2:1, add water at room temperature and stir to dissolve, and control pH=6. Add 0.4g Tween T-80, stir evenly, then add 0.9g octyl methoxycinnamate, shear at high speed for 5min, control the speed = 10000rpm, and use it as the core material solution. Add the core material solution dropwise to the chitosan solution, the mass ratio of chitosan: gum arabic: sodium caseinate is 2.5:2:1, control the speed = 250rpm, after the dropwise addition, control the temperature at 45°C for 1h , and then lowered to 4 ° C for 1 h, and then added glutaraldehyde for cross-linking reaction for 1 h to prepare liquid microcapsules. The liquid microcapsules were added into 1% glutaraldehyde aqueous solution an...

Embodiment 3

[0042] Weigh chitosan with a molecular weight of 5kda and a degree of deacetylation of 90% and place it in a beaker to prepare a 1% chitosan-water solution, add acetic acid to swell and adjust the solution to pH = 3, and set it aside. Weigh gum arabic and sodium caseinate with a mass ratio of 1:1, add water at room temperature and stir to dissolve, and control pH=6. Add 0.4g Tween T-80, stir evenly, then add 0.9g octyl methoxycinnamate, shear at high speed for 5min, control the speed = 10000rpm, and use it as the core material solution. Add the core material solution dropwise to the chitosan solution, the mass ratio of chitosan: gum arabic: sodium caseinate is 1:1:1, control the speed = 400rpm, after the dropwise addition, control the temperature at 40°C for 1h , and then lowered to 8 ° C for 1 hour of reaction, adding glutaraldehyde for cross-linking reaction of 1 hour to prepare liquid microcapsules. The liquid microcapsules were added to 2% glutaraldehyde aqueous solution ...

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Abstract

The invention discloses a hydrophobic sun-screening microcapsule and a preparation method thereof. The microcapsule comprises a core material and wall materials in the mass ratio being (1:1)-(4:1), wherein the core material is octyl methoxycinnamate and the wall materials comprise chitosan, Arabic gum and sodium caseinate. The microcapsule takes a natural high-molecular polymer as the wall materials and coats organic sun-screening agent octyl methoxycinnamate with a complex coacervation method, and the complex coacervation method is that the wall materials with opposite charges at certain pH values are mixed in a certain ratio to react and then coat the core material. The microcapsule has good spheres, can effectively coat the organic sun-screening agent, prevent the sun-screening agent from directly contacting with skin, can exist in an aqueous solution stably and has good compatibility in sun-screening cosmetics.

Description

technical field [0001] The invention belongs to the field of fine chemicals, and in particular relates to a preparation technology of hydrophobic sunscreen microcapsules. Background technique [0002] In recent years, with the thinning of the ozone layer and the increasing ultraviolet rays reaching the ground, the impact on human beings has been recognized worldwide. Ultraviolet rays in sunlight are divided into three types: ultraviolet C (200-290 nm); ultraviolet B (290-320 nm); ultraviolet A (320-400 nm). 95% to 98% of ultraviolet rays in the atmosphere are long-wave ultraviolet rays, and 2% to 5% are medium-wave ultraviolet rays. Long-wave ultraviolet rays can penetrate glass, some clothing and the epidermis, causing damage to the dermis and subcutaneous tissue, mainly causing photoaging, photosensitivity reactions and immunosuppression, and some are also involved in sunburn reactions and the formation of skin tumors. UVB is the main UV light that causes sunburn, skin t...

Claims

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Application Information

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IPC IPC(8): A61K8/11A61K8/37A61K8/73A61K8/64A61Q17/04
CPCA61K8/11A61K8/37A61K8/64A61K8/736A61K8/737A61Q17/04
Inventor 纪红兵曾雪敏徐春涛李有梅
Owner HUIZHOU RES INST OF SUN YAT SEN UNIV
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