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A rapid screening method for five coumarin compounds in toys

A technology of coumarins and compounds, which is applied in the field of rapid screening of 5 kinds of coumarins in toys, can solve the problem of cumbersome instruments, inability to meet rapid on-site screening, and inability to simultaneously satisfy sensitivity, selectivity and analytical throughput. Quantity and other issues to achieve fast results

Active Publication Date: 2020-04-10
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the methods for detecting coumarin compounds in toys mainly include high-performance liquid chromatography, etc., but they cannot meet the requirements of sensitivity, selectivity and analytical throughput at the same time, and most of the instruments are heavy and cumbersome to operate, which cannot meet the requirements of rapid on-site screening needs

Method used

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  • A rapid screening method for five coumarin compounds in toys
  • A rapid screening method for five coumarin compounds in toys
  • A rapid screening method for five coumarin compounds in toys

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Experimental program
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Embodiment Construction

[0040] 1. Instruments and devices

[0041] P-1000 microelectrode puller, borosilicate glass capillary (outer diameter 1.5mm, inner diameter 0.86mm, length 5cm) (Sutter, USA); ESW-M15P metal microelectrode (Warner Instruments, USA); GA2100 Type Portable Ion Mobility Spectrometer (Excellims, USA): Equipped with ion gate controller, air filtration device (containing calcium sulfate and molecular sieve), high-resolution ion mobility analyzer, VisIon instrument control and data processing system, and chromatographic analysis before use Amino acid and citric acid were used to calibrate the instrument in positive and negative ion modes respectively; Milli-Q ultrapure water device (Millipore, USA); pipette tips used in the experiment were imported (Bio-Rad, USA).

[0042] 2. Materials and Reagents

[0043] The standard substances of 5 kinds of coumarin compounds are commercially available with the highest purity standard samples. The standard products of various coumarin compounds ar...

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Abstract

The invention discloses a rapid screening method of five kinds of coumarin compounds in toys. The method comprises placing a sample to be tested in a carrier containing an extraction solvent, applyinghigh pressure to form electron spray and carrying out on-line analysis in real time according to an ion mobility spectrum. The five kinds of the coumarin compounds comprise dicoumarol, 7-methylcoumarin, 7-methoxycoumarin, 7-ethoxy- 4-methylcoumarin and coumarin. The method has the advantages of fastness, stability, low cost and simple operation.

Description

technical field [0001] The invention relates to a detection method of chemical substances, in particular to a rapid screening method for five coumarin compounds in toys. Background technique [0002] my country is the world's largest toy manufacturer and exporter, and nearly 70% of the world's toys are made in China. However, while the toy industry is speeding up my country's economic development and providing children with a rich and colorful life, quality and safety incidents caused by unqualified toys often occur. Toxic and harmful substances added to toy products can enter children's bodies through swallowing, licking, skin contact, eye contact, inhalation, etc., seriously endangering children's health. [0003] At present, the methods for detecting coumarin compounds in toys mainly include high-performance liquid chromatography, etc., but they cannot meet the requirements of sensitivity, selectivity and analytical throughput at the same time, and most of the instrument...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/62G01N1/40
Inventor 马强闫萌萌郭项雨孟宪双白桦吕悦广胡明珠陈萌
Owner CHINESE ACAD OF INSPECTION & QUARANTINE