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Application of nostoc commune vauch alcohol extract to preparation of medicines for treating inflammatory bowel disease

A technology of inflammatory bowel disease and vegetable alcohol, which is applied in the application field of the ethanol extract of barley vegetable in the preparation of drugs for the treatment of inflammatory bowel disease, and can solve the problem of poor treatment effect and the inflammatory bowel disease that has not yet been seen with the alcohol extract of barley vegetable disease

Active Publication Date: 2018-01-16
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although targeting a single inflammatory factor may be an alternative therapy for UC, the treatment effect is usually poor
However, there is no relevant report on the application of the ethanol extract of Dipis radiata in the treatment of inflammatory bowel disease.

Method used

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  • Application of nostoc commune vauch alcohol extract to preparation of medicines for treating inflammatory bowel disease
  • Application of nostoc commune vauch alcohol extract to preparation of medicines for treating inflammatory bowel disease
  • Application of nostoc commune vauch alcohol extract to preparation of medicines for treating inflammatory bowel disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take the ground vegetables and dry them at 80°C for 8 hours in an electric constant temperature blast drying oven to obtain the dried ground vegetables; place the dried ground vegetables in an extraction tank, add 80v / v% ethanol to reflux and extract for 3 times ( The amount of solvent added during each extraction is respectively 10 times, 8 times and 5 times the weight of the dried ground vegetable, respectively, and the three extraction times are respectively 2 hours, 1.5 hours and 1 hour); the combined extracts , filtered, and the filtrate was concentrated to no alcohol to obtain the ethanol extract of Dipicarina.

Embodiment 2

[0029] Take the ground vegetables and dry them in an electric constant temperature blast drying oven at 60°C for 5 hours to obtain the dried ground vegetables; place the dried ground vegetables in an extraction tank, add 100v / v% ethanol to reflux and extract once ( The amount of the solvent added is 12 times the mass of the dried Dipis radiata, and the extraction time is 3 hours); the filtrate is filtered, and the filtrate is concentrated to no alcohol to obtain the ethanol extract of Dipis radiata.

Embodiment 3

[0031] Take the ground vegetables and dry them at 40° C. for 12 hours in an electric constant temperature blast drying oven to obtain the dried ground vegetables; place the dried ground vegetables in an extraction tank, add 20v / v% methanol to reflux and extract twice ( The addition amount of solvent during each extraction is successively respectively 10 times amount, 10 times amount of the quality of ground vegetable after drying, and the extraction time of 2 times is successively respectively 3 hours, 2 hours); Merge extract, filter, and filtrate is concentrated to Alcohol-free, to obtain the ethanol extract of Dipis officinalis.

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Abstract

The invention discloses application of a nostoc commune vauch alcohol extract to preparation of medicines for treating an inflammatory bowel disease. A preparation method of the nostoc commune vauch alcohol extract comprises the following steps: taking nostoc commune vauch, using low-carbon alcohol as a solvent, extracting under a heating condition, collecting an extract, recycling the solvent toobtain the nostoc commune vauch alcohol extract. Through experiments, the applicant finds that the nostoc commune vauch alcohol extract significantly improves the weight loss of a DSS (dextran sulphate sodium)-induced UC (ulcerative colitis) model mouse, inhibits DAI (disease activity index) score increase, relieves UC-induced mouse colon length reduction and reduces inflammatory cell infiltrationand tissue damage; in addition, the nostoc commune vauch alcohol extract significantly reduces the contents of colon tissue cytokines TNF-alpha and IL-6, and such effect is closely related to activation of a key transcription factor NF-kappaB inhibiting inflammatory signaling pathways. Experimental results of the applicant show that the nostoc commune vauch alcohol extract can be used for treating the inflammatory bowel disease, relieving an inflammatory reaction of the DSS-induced UC model and improving the UC severity.

Description

technical field [0001] The invention relates to the application of the plant extract, in particular to the application of the ethanol extract of the barkleaf in the preparation of medicine for treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease that mainly affects the ileum, rectum, and colon. The clinical manifestations are diarrhea, abdominal pain, and even bloody stool. The disease includes ulcerative colitis (UC) and Crohn's disease (CD). Ulcerative colitis is a continuous inflammation of the colonic mucosa and submucosa. The disease usually involves the rectum first and then gradually spreads to the entire colon. Crohn's disease can involve the entire digestive tract and is a discontinuous full-thickness inflammation. The most common site of involvement is Terminal ileum, colon and perianal area. As a typical inflammatory bowel disease, UC occurs in young adults aged 30-40...

Claims

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Application Information

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IPC IPC(8): A61K35/748A61P1/00A23L33/135
Inventor 段小群王宇晖徐笑天苑博朱梦玲曹后康
Owner GUILIN MEDICAL UNIVERSITY
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