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Flexible electrode array-optical fiber composite neutral electrode and its preparation method

A flexible electrode and composite nerve technology, applied in the fields of neuroscience and bio-instrument engineering, can solve the problems of spatial accuracy and mechanical performance limitations, and achieve the effect of reducing damage and improving flexibility

Active Publication Date: 2018-01-30
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most commonly used photoelectric composite electrode is realized by the integration of optical fiber and microwire electrode. The photoelectric composite electrode is economical and practical, but its spatial accuracy and mechanical properties have great limitations.

Method used

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  • Flexible electrode array-optical fiber composite neutral electrode and its preparation method
  • Flexible electrode array-optical fiber composite neutral electrode and its preparation method
  • Flexible electrode array-optical fiber composite neutral electrode and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Fabrication of Flexible Electrode Arrays

[0068] 1. Electrode design;

[0069] (1) Mesh electrodes:

[0070] Solder joints: rectangular, 2mm long, 0.7mm wide, 1mm apart, 10 channels evenly arranged.

[0071] Recording site: circular, 30 μm in diameter, see Figure 4 for the arrangement.

[0072] Substrate layer SU8-1 layer: thickness 5 μm, horizontal stripe width 20 μm, length 1.115 mm, spacing 500 μm; vertical stripe width 35 μm, length 15 mm. The electrode longitudinal strip and the cable part are connected by an arc to avoid stress concentration.

[0073] Conductive layer Au layer: The width of the conductive Au line is 15 μm, the thickness is 100 nm, and the thickness of the Cr layer of the adhesion layer is 5 nm.

[0074] Insulation layer SU8-2 layer: thickness 0.5μm, the difference from SU8-1 lies in the following points, the disc electrode with a diameter of 30μm at the recording site is exposed, the first channel and the tenth channel are completely exposed ...

Embodiment 2

[0114] 3D printing support structure

[0115] Design the three-dimensional graphics of the support structure on the PROE three-dimensional graphic design software; the size parameters are as follows: the length of the support structure is 18 mm; the width of the support structure is 15 mm; the thickness of the support structure is 1 mm; the aperture of the support structure is 2.40 mm; save as . STL format.

[0116] On the CoLiDo 3D printer supporting software Print-Rite Repetier-Host, adjust the material parameters and the location and method of printing, click to automatically generate the Slic3r code, save it in the .GCO format to the printer’s supporting memory card, and start printing.

Embodiment 3

[0118] Flexible electrode array / optical fiber composite nerve electrode

[0119] The size of the optical fiber used in the present invention is as follows: Fiber core

[0120] Assemble the optical fiber and the optical fiber support, then place the electrode on the optical fiber support, pay attention to center the optical fiber and the electrode position left and right, so that the electrode is about 0.5mm beyond the optical fiber; then put it into deionized water, pull it out vertically, and curl the electrode into a package Cover the surface of the optical fiber, then put the flexible electrode array / fiber composite nerve electrode into the cured material melted at high temperature for curing, and finally fix the electrode and the supporting structure with copper tape.

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PUM

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Abstract

The invention provides a flexible electrode array-optical fiber composite neutral electrode. The neutral electrode comprises a flexible electrode array, an optical fiber and a supporting structure; the surface of the supporting structure is provided with a groove, and the optical fiber is fixed at the inner part of the groove; the flexible electrode array comprises a welding point zone, an interconnection lead zone and a recording site zone which are connected in order; the welding point zone is fixed at the surface of the supporting structure; the interconnection lead zone and the recording site zone are coated at the surface of the optical fiber in a rolling manner. The composite neutral electrode after being cured through polyethylene glycol (PEG) can be planted tin a specific brain zone of a brain; a light signal is induced through the optical fiber, thus release of an electrical physiological signal of a specific type of neutral element of a specific brain zone can be simulated orinhibited, and then the flexible electrode array detects the electrical physiological signal of the neutral element; the detection of the electrical physiological signal can be organically combined with the light inheritance; the flexible electrode array-optical fiber composite neutral electrode has great application value to study a neural circuit, nerve diseases, nerve prosthesis and others.

Description

technical field [0001] The invention relates to the technical fields of neuroscience and biological instrument engineering, in particular to a flexible electrode array / optical fiber composite nerve electrode and a preparation method thereof. Background technique [0002] Neural electrodes are a hot research topic in brain-computer interface technology, which can provide an information interaction interface between brain neurons and electronic systems, and have important application prospects in neurocognitive behavior and disease treatment. Existing nerve electrodes include electroencephalogram (EEG) electrodes, cerebral cortex (ECoG) electrodes, and implanted electrodes, among which implanted nerve electrodes, especially implanted nerve electrode arrays, can distinguish the electrical activity of individual nerve cells through action potentials. activity, enabling simultaneous detection of electrical activity in a large range of neurons with high spatiotemporal resolution. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/04A61B5/00
Inventor 方英邹亮王晋芬管寿梁
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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