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Wormwood catalytic aging technology and aged wormwood

A wormwood and process technology, applied in the pharmaceutical field, can solve the problems of difficulty in producing wormwood with a degree of aging, low production efficiency, long time consumption, etc., so as to promote the aging of wormwood, shorten the aging period, and prevent wormwood. moldy effect

Inactive Publication Date: 2018-02-23
河南省三禾药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional method of aging wormwood takes too long, and the production efficiency is too low for the pharmaceutical industry, and it is difficult to produce aged wormwood with a high degree of aging.

Method used

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  • Wormwood catalytic aging technology and aged wormwood
  • Wormwood catalytic aging technology and aged wormwood
  • Wormwood catalytic aging technology and aged wormwood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Wash the purchased high-quality fresh wormwood, and dry it in an environment with a temperature of 28°C and a humidity of less than 20%, and then use 60 Co-r radiation is irradiated for 1 minute to sterilize the air-dried wormwood surface. After the sterilization is completed, the Bacillus concentration of 6×10 per ml is sprayed on the surface. 9 Each microbial inoculum is air-dried. After air-drying, place the wormwood in an airtight container, and pour ethylene oxide and oxygen into the airtight container to make the ethylene oxide concentration in the airtight container 250g / m 3 , The oxygen concentration is 730g / m 3 Make the pressure in the airtight container 1.76 times the external pressure, place the airtight container with ethylene oxide and oxygen in an environment where the light intensity is less than or equal to 0.8lx, and control the humidity in the airtight container to 42% and the temperature to 23°C.

Embodiment 2

[0036] Wash the purchased high-quality fresh wormwood and dry it in an environment with a temperature of 33°C and a humidity of less than 20%, and then use 60 Co-r radiation is irradiated for 6 minutes to sterilize the surface of the air-dried wormwood. After the sterilization is completed, spray the Bacillus concentration of 12×10 per ml on the surface. 9 Each microbial inoculum is air-dried. After air-drying, place the wormwood in an airtight container, and pour ethylene oxide and oxygen into the airtight container so that the concentration of ethylene oxide in the airtight container is 500g / m 3 , The oxygen concentration is 1260g / m 3 And a small amount of nitrogen makes the pressure in the closed container 2.62 times of the external pressure. Place the closed container with ethylene oxide and oxygen in an environment where the light intensity is less than or equal to 0.8lx, and control the humidity in the closed container to 76% , The temperature is 28℃.

Embodiment 3

[0038] Wash the purchased high-quality fresh wormwood, and dry it in an environment with a temperature of 30°C and a humidity of less than 20%, and then use 60 Co-r rays are irradiated for 3 minutes to sterilize the air-dried wormwood surface. After the sterilization is completed, spray the Bacillus concentration of 10×10 per ml on the surface. 9 The concentration of micrococcus is 5×10 per ml 8 Each microbial inoculum is air-dried. After air-drying, place the wormwood in a closed container, and pour ethylene oxide and oxygen into the closed container so that the concentration of ethylene oxide in the closed container is 300g / m 3 , The oxygen concentration is 800g / m 3 Make the pressure in the airtight container 1.85 times the external pressure, place the airtight container with ethylene oxide and oxygen in an environment where the light intensity is less than or equal to 0.8lx, and control the humidity in the airtight container to 50% and the temperature to 25°C.

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Abstract

The invention relates to the technical field of pharmacy and provides a wormwood catalytic aging technology. The wormwood catalytic aging technology comprises carrying out air drying on fresh wormwoodat 28-33 DEG C at humidity of less than 20%, carrying out surface sterilization on the air-dried wormwood, spraying a microbial agent containing 6*10<9> to 12*10<9> per milliliter of bacilli to the wormwood subjected to surface sterilization, carrying out airing, putting the wormwood into a closed container, and feeding ethylene oxide and oxygen into the closed container so that pressure in the closed container is greater than or equal to the external pressure, an ethylene oxide concentration in the closed container is 250-500 g / m<3> and an oxygen concentration is 730-1260 g / m<3>. The wormwood catalytic aging technology effectively shortens wormwood aging time. The invention provides wormwood prepared through the wormwood catalytic aging technology. The wormwood has a short aging period and has properties similar to or better than those of the natural aged wormwood.

Description

Technical field [0001] The invention relates to the technical field of pharmacy, in particular to a wormwood aging process and Chen Ai. Background technique [0002] Mugwort (scientific name: Artemisia argyi H.Lév.&Vaniot), aliases: Xiaomao, Bingtai, Cured Grass, Fragrant Wormwood, Artemisia Aixiao, Mugwort, Mugwort, Penggai, Moxa, Moxibustion, Medical Herb , Yellow grass, moxa, etc. Perennial herb or slightly semi-shrub-like, plant has a strong aroma. The stem is solitary or a few, brown or grayish-yellow, the base is slightly lignified, the upper part is lucid, and there are a few short branches, the leaves are thick and papery, and the upper part is gray-white pubescent. The base usually has no false stipules or very small False stipules; the upper leaves and bracts are pinnately half-cleaved, the inflorescence head is oval, the corolla is tubular or goblet, with glands on the outside, the anthers are narrowly linear, the style and the corolla are nearly as long or slightly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61L2/10
CPCA61K36/282A61K2236/10A61K2236/13A61K2236/17A61K2236/19A61L2/0047
Inventor 王雯丽石洪瑞石洪蔚石胜勋王丽李强刘彦锋
Owner 河南省三禾药业有限公司
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