High-throughput roller bottle culture device

Abstract

The invention discloses a high-throughput roller bottle culture device, which comprises at least one sleeve part whose inner diameter matches the outer diameter of the roller bottle, and a driving assembly for driving the rotation of the sleeve part. When cell culture is carried out, the roller bottle is placed in the sleeve part adapted to its outer diameter, and the drive assembly is used to drive the sleeve part to rotate so as to drive the roller bottle to rotate together. This is an active driving method, which is different from conventional culture devices. Driven by the friction between the roller and the surface of the roller bottle, it has low requirements on the material and shape of the roller bottle, and the cost of cultivation is low, and the synchronization rate of the rotation of each roller bottle in the active driving method is high, thereby improving the uniformity of the cell growth level. The sleeve parts are arranged in 7 rows and 7 columns, and each sleeve part is provided with 4 roller bottle accommodating positions along the length direction of the sleeve. The device handles a large amount of samples, and can process up to 196 roller bottles at the same time, which greatly improves the efficiency of cell culture.

Description

technical field [0001] The invention belongs to the technical field of biomedical devices, and relates to a roller bottle device, in particular to a high-throughput roller bottle culture device. Background technique [0002] In the process of deep cell culture, the most important thing is to provide a suitable environment for cell growth. In the body, cells often exist in a dense layered form. Cell tissues contain special components in their original form and can strongly affect Regulation of cellular functions by exposure of biomolecules to biological fluids. Cells separated from biological organisms are generally difficult to adapt to the traditional microbial culture environment, resulting in the characteristics of slow growth rate, easy to be infected with bacteria, large individuals and wasted, aerobic but not strong agitation. These characteristics make the container for cultivating cells The design is complicated, and traditional microbial reactors generally cannot b...

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Problems solved by technology

[0004] For this reason, the technical problem to be solved by the present invention is that the traditional incubator has a small amount of samples to be processed, low efficiency, high requirements on the material of the culture bottle, and poor synchronization between the culture bottle and the roller. A high-throughput roller bottle culture device with low requirements on culture bottle material, low culture cost and high degree of automation

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