High-throughput roller bottle culture device

Abstract

The invention discloses a high-throughput roller bottle culture device which comprises at least one sleeve piece with the inner diameter matched with the outer diameter of each roller bottle and a driving component used for driving the sleeve piece to rotate. When in cell culture, each of the roller bottle is put in each of the sleeve pieces matched with the outer diameter of the roller bottles; the sleeve pieces are driven by the driving component to rotate, so as to drive the roller bottles to rotate synchronously; the manner is an active driving manner and is different from the conventionalculture device, and the roller bottles are driven not by depending on the friction force of rollers and the outer surfaces of the roller bottles; the requirements on the material and the shape of theroller bottles are low, and the culture cost is low; in addition, through adoption of the active driving manner, the synchronous rate of the rotation of each roller bottle is high, so that the uniformity of the cell growth level is improved. The sleeve pieces are arranged in seven rows and seven lines, and four roller bottle containing positions are arranged in each of the sleeve pieces in the length direction of the sleeve piece. The device is large in treatment capacity of samples and can be used for treating 196 roller bottles simultaneously at most, so that the cell culture efficiency isgreatly improved.

Description

technical field [0001] The invention belongs to the technical field of biomedical devices, and relates to a roller bottle device, in particular to a high-throughput roller bottle culture device. Background technique [0002] In the process of deep cell culture, the most important thing is to provide a suitable environment for cell growth. In the body, cells often exist in a dense layered form. Cell tissues contain special components in their original form and can strongly affect Regulation of cellular functions by exposure of biomolecules to biological fluids. Cells separated from biological organisms are generally difficult to adapt to the traditional microbial culture environment, resulting in the characteristics of slow growth rate, easy to be infected with bacteria, large individuals and wasted, aerobic but not strong agitation. These characteristics make the container for cultivating cells The design is complicated, and traditional microbial reactors generally cannot b...

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Problems solved by technology

[0004] For this reason, the technical problem to be solved by the present invention is that the traditional incubator has a small amount of samples to be processed, low efficiency, high requirements on the material of the culture bottle, and poor synchronization between the culture bottle and the roller. A high-throughput roller bottle culture device with low requirements on culture bottle material, low culture cost and high degree of automation

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